Prolactin receptor gene transcriptional control, regulatory modalities relevant to breast cancer resistance and invasiveness

Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors

(2022) Bernadette Xin Jie Tune et al.   Journal of Oncology

The human intermediate prolactin receptor is a mammary proto-oncogene

(2021) Jacqueline M. Grible et al.   npj Breast Cancer

Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer

(2021) Alicia E. Woock et al.   Scientific Reports

Crosstalk between PRLR and EGFR/HER2 Signaling Pathways in Breast Cancer

(2021) Raghuveer Kavarthapu et al.   Cancers

HER2-positive breast cancer and tyrosine kinase inhibitors: the time is now

(2021) Ilana Schlam et al.   npj Breast Cancer

The Relevant Participation of Prolactin in the Genesis and Progression of Gynecological Cancers

(2021) Adrián Ramírez-de-Arellano et al.   Frontiers in Endocrinology

Phase I Study of LFA102 in Patients With Advanced Breast Cancer or Castration-resistant Prostate Cancer

(2020) HIRONOBU MINAMI et al.   ANTICANCER RESEARCH

Involvement of STAT5 in Oncogenesis

(2020) Clarissa Esmeralda Halim et al.   Biomedicines

Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy

(2019) Aradhana Rani et al.   Frontiers in Endocrinology

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models

(2018) Katherine A. Leehy et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Prolactin receptor targeting in breast and prostate cancers: New insights into an old challenge

(2017) Vincent Goffin   PHARMACOLOGY & THERAPEUTICS

Essential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cells

(2017) Raghuveer Kavarthapu et al.   Oncotarget

Synergistic Activation of ER  by Estrogen and Prolactin in Breast Cancer Cells Requires Tyrosyl Phosphorylation of PAK1

(2016) P. Oladimeji et al.   CANCER RESEARCH

Endocrine resistance in hormone-responsive breast cancer: mechanisms and therapeutic strategies

(2016) Conleth G Murphy et al.   ENDOCRINE-RELATED CANCER

Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration

(2016) Katherine M. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk

(2016) Zeina Chakhtoura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endocrine Therapy for Hormone Receptor–Positive Metastatic Breast Cancer: American Society of Clinical Oncology Guideline

(2016) Hope S. Rugo et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer

(2016) Ciara C. O’Sullivan et al.   ONCOLOGIST

A combined computational and structural model of the full-length human prolactin receptor

(2016) Katrine Bugge et al.   Nature Communications

Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells

(2016) Raghuveer Kavarthapu et al.   Oncotarget

Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells

(2016) Craig E. Barcus et al.   Oncotarget

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

(2015) Gitte W. Haxholm et al.   BIOCHEMICAL JOURNAL

Better Together: Targeted Combination Therapies in Breast Cancer

(2015) Elisa Zanardi et al.   SEMINARS IN ONCOLOGY

Dense Collagen-I Matrices Enhance Pro-Tumorigenic Estrogen-Prolactin Crosstalk in MCF-7 and T47D Breast Cancer Cells

(2015) Craig E. Barcus et al.   PLoS One

Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERα and STAT5

(2015) Raghuveer Kavarthapu et al.   Oncotarget

Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort

(2014) K. Tikk et al.   ANNALS OF ONCOLOGY

Impact of subdomain D1 of the short form S1b of the human prolactin receptor on its inhibitory action on the function of the long form of the receptor induced by prolactin

(2014) J.-H. Kang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers

(2014) Elisavet Paplomata et al.   Therapeutic Advances in Medical Oncology

A 20-Year Prospective Study of Plasma Prolactin as a Risk Marker of Breast Cancer Development

(2013) S. S. Tworoger et al.   CANCER RESEARCH

Stiff Collagen Matrices Increase Tumorigenic Prolactin Signaling in Breast Cancer Cells

(2013) Craig E. Barcus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer

(2013) Sarah R. Walker et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular Mechanisms of Prolactin and Its Receptor

(2012) Charles L. Brooks   ENDOCRINE REVIEWS

The WSXWS Motif in Cytokine Receptors Is a Molecular Switch Involved in Receptor Activation: Insight from Structures of the Prolactin Receptor

(2012) Robert Dagil et al.   STRUCTURE

Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells

(2011) Edita Aksamitiene et al.   CELLULAR SIGNALLING

Complex Formation and Interactions between Transcription Factors Essential for Human Prolactin Receptor Gene Transcription

(2011) J.-H. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

Progesterone induces expression of the prolactin receptor gene through cooperative action of Sp1 and C/EBP

(2011) Anita S. Goldhar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Role of phosphorylation in progesterone receptor signaling and specificity

(2011) Christy R. Hagan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells

(2010) Kevin J. Johnson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Amplification of the prolactin receptor gene in mammary lobular neoplasia

(2010) Danh Tran-Thanh et al.   BREAST CANCER RESEARCH AND TREATMENT

Prolactin and oestrogen synergistically regulate gene expression and proliferation of breast cancer cells

(2010) Louise Maymann Rasmussen et al.   ENDOCRINE-RELATED CANCER

New concepts in prolactin biology

(2010) Sophie Bernichtein et al.   JOURNAL OF ENDOCRINOLOGY

Association of gene polymorphisms in prolactin and its receptor with breast cancer risk in Taiwanese women

(2010) Fan-Yun Mong et al.   MOLECULAR BIOLOGY REPORTS

Prolactin Receptor–Integrin Cross-Talk Mediated by SIRPα in Breast Cancer Cells

(2010) Traci Galbaugh et al.   MOLECULAR CANCER RESEARCH

Impact of prolactin receptor isoforms on reproduction

(2010) Nadine Binart et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Prolactin Exerts a Prosurvival Effect on Human Spermatozoa via Mechanisms that Involve the Stimulation of Akt Phosphorylation and Suppression of Caspase Activation and Capacitation

(2009) Dwi Ari Pujianto et al.   ENDOCRINOLOGY

Characterization of Two Constitutively Active Prolactin Receptor Variants in a Cohort of 95 Women with Multiple Breast Fibroadenomas

(2009) Carine Courtillot et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Short form 1b human prolactin receptor down-regulates expression of the long form

(2009) Dunyong Tan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Intramolecular Disulfide Bonds of the Prolactin Receptor Short Form Are Required for Its Inhibitory Action on the Function of the Long Form of the Receptor

(2009) Y.-L. Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the unliganded estrogen receptor by prolactin in breast cancer cells

(2009) L González et al.   ONCOGENE

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues

(2009) Y Sangeeta Devi et al.   Reproductive Biology and Endocrinology

Prolactin receptor expression in gynaecomastia and male breast carcinoma

(2008) M Ferreira et al.   HISTOPATHOLOGY

Prolactin and Breast Cancer Etiology: An Epidemiologic Perspective

(2008) Shelley S. Tworoger et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors

(2008) R. L. Bogorad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S2 Deletion Variants of Human PRL Receptors Demonstrate That Extracellular Domain Conformation Can Alter Conformation of the Intracellular Signaling Domain†

(2007) Dunyong Tan et al.   BIOCHEMISTRY