Journal
FRONTIERS IN GENETICS
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.848985
Keywords
microRNAs; autoimmunity; Treg cells; Th17 cells; intermediate; posterior; uveitis (MeSH)
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Funding
- Guangxi Science and Technology Base and Talent Special Fund
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Guangxi Clinical Ophthalmic Research center
- National Natural Science Foundation of China
- [2018GXNSFBA050057]
- [82000925]
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Th17 and regulatory T cells play crucial roles in autoimmune diseases, and microRNAs have emerged as important regulators in maintaining the balance between these cell types. This review summarizes the involvement and potential role of microRNAs in autoimmune uveitis and the regulation of Th17/Treg homeostasis.
Th17 and regulatory T cells (Tregs) play crucial roles in the pathogenesis of autoimmune diseases. Th17/Treg homeostasis is critically involved in maintaining the immune balance. Disturbed Th17/Treg homeostasis contributes to the progression of autoimmune diseases. MicroRNAs (miRNAs) have emerged as a new vital factor in the regulation of disturbed Th17/Treg homeostasis. To better understand the epigenetic mechanisms of miRNAs in regulating Treg/Th17 homeostasis, we included and evaluated 97 articles about autoimmune diseases and found that miRNAs were involved in the regulation of Treg/Th17 homeostasis from several aspects positively or negatively, including Treg differentiation and development, Treg induction, Treg stability, Th17 differentiation, and Treg function. Uveitis is one of the ocular autoimmune diseases, which is also characterized with Th17/Treg imbalance. However, our understanding of the miRNAs in the pathogenesis of uveitis is elusive and not well-studied. In this review, we further summarized miRNAs found to be involved in autoimmune uveitis and their potential role in the regulation of Th17/Treg homeostasis.
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