Article
Medicine, General & Internal
Theodoros Koutsomitros, Kenneth T. van der Zee, Olympia Evagorou, Teresa Schuhmann, Antonis C. Zamar, Alexander T. Sack
Summary: This open-label naturalistic study examined the feasibility, tolerability, and effectiveness of a repetitive transcranial magnetic stimulation (rTMS) protocol for treating patients with bipolar disorder type II. The study found that the rTMS treatment significantly reduced depression symptoms both immediately after treatment and one month later.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Samar S. Ayache, Nicolas Serratrice, Georges N. Abi Lahoud, Moussa A. Chalah
Summary: Fatigue is a common and debilitating symptom in multiple sclerosis (MS), affecting the patients' quality of life. It exhibits motor, cognitive, and psychosocial facets, and can be differentiated from perceived fatigue and fatigability. Despite existing literature, the pathophysiology and management of MS fatigue remain challenging.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giovanni Cirillo, Roberta Pepe, Mattia Siciliano, Domenico Ippolito, Dario Ricciardi, Manuela de Stefano, Daniela Buonanno, Danilo Atripaldi, Salvatore Abbadessa, Brunella Perfetto, Minoo Sharbafshaaer, Giovanna Sepe, Simona Bonavita, Alessandro Iavarone, Vincenzo Todisco, Michele Papa, Gioacchino Tedeschi, Sabrina Esposito, Francesca Trojsi
Summary: This study evaluated the effects of bilateral rTMS on plasmatic levels of MMPs and TIMPs, as well as cognitive performances, in MCI patients. The results showed that rTMS treatment reduced MMP1, -9, and -10 levels, increased TIMP1 and TIMP2 levels, and improved visuospatial performances in MCI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rehabilitation
Michele Vecchio, Rita Chiaramonte, Paolo Di Benedetto
Summary: This study aims to investigate the efficacy of rehabilitation programs for bladder disorders in patients with multiple sclerosis (MS) and to provide guidance for physicians in delineating therapeutic tools and programs. The systematic review identified specific rehabilitation treatments reported in the current literature and compared the scores and scales used to quantify bladder disorders before and after rehabilitation.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lara Kular, Ewoud Ewing, Maria Needhamsen, Majid Pahlevan Kakhki, Ruxandra Covacu, David Gomez-Cabrero, Lou Brundin, Maja Jagodic
Summary: This study examines DNA methylation in glial cells to uncover molecular changes underlying Multiple Sclerosis (MS) neuropathology. The researchers identified significant differential methylation positions between MS patients and controls, and found alterations in processes related to cellular motility, metabolic processes, neuroinflammation, and signaling. Genes affected by the methylation changes showed transcriptional differences in the brains of MS patients. The findings suggest a multicellular reaction in response to inflammation in the absence of lesional insult.
Article
Clinical Neurology
Shunaha Kim-Fine, Jamie Greenfield, Kathleen H. Chaput, Magali Robert, Luanne Metz
Summary: The study examined the trends of personal cannabis use among people with MS in Canada, finding that a majority of cannabis users primarily used it for medical purposes. Common reasons for cannabis use included improving sleep, alleviating pain, relaxation, muscle spasms, reducing anxiety, and managing depression.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Review
Psychiatry
G. Schiena, G. Franco, A. Boscutti, G. Delvecchio, E. Maggioni, P. Brambilla
Summary: rTMS treatment induces significant changes in functional connectivity between emotion regulation areas and resting-state networks in the brain. Diffusion tensor imaging studies suggest an increase in fractional anisotropy in the frontal lobe after rTMS. However, limitations such as small sample sizes and heterogeneity in stimulation parameters may impact the generalizability of the results.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)
Article
Chemistry, Analytical
Luana Cecilia Farache Lemos Leal, Luiz Henrique Bertucci Borges, Maria Eduarda Franklin da Costa De Paula, Lilian Lira Lisboa, Andre Felipe Oliveira de Azevedo Dantas
Summary: This study aims to develop and validate a neuromodulation device that can be remotely programmed and properly monitored for treating neurogenic bladder. The device was tested and validated according to Brazilian Regulatory Standard, and showed reliability and effectiveness in real applications.
Article
Neurosciences
Roberta Stroher Toledo, Dirson Joao Stein, Paulo Roberto Stefani Sanches, Lisiane Santos da Silva, Helouise Richardt Medeiros, Felipe Fregni, Wolnei Caumo, Iraci L. S. Torres
Summary: The study evaluated the effects of rTMS treatment on the nociceptive response in rats with neuropathic pain model as well as its impact on pro-and anti-neuroinflammatory cytokine and neurotrophin levels. rTMS treatment partially reversed mechanical allodynia and completely reversed thermal hyperalgesia induced by CCI, while also increasing levels of BDNF, TNF-alpha, and IL-10 in the PFC.
Article
Medicine, General & Internal
Maarten Belgers, Philip Van Eijndhoven, Wiebren Markus, Aart H. Schene, Arnt Schellekens
Summary: This study demonstrated that high-frequency rTMS over the right dorsolateral prefrontal cortex, combined with standard treatment, significantly reduced alcohol craving and use in recently detoxified patients with AUD, with the most significant effects observed in the first month post-detoxification.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Fatemeh Guitynavard, Omid Mirmosayyeb, Emami Razavi V. S. Razavi, Maryam Hosseini, Ali Mahdi Hosseinabadi, Mahsa Ghajarzadeh, Mohaddeseh Azadvari
Summary: This systematic review and meta-analysis found that PTNS is effective in treating lower urinary tract symptoms in patients with multiple sclerosis.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Neurosciences
Nastaran Majdinasab, Neda Orakifar, Leila Kouti, Gholamreza Shamsaei, Maryam Seyedtabib, Mohammad Jafari
Summary: This study compared the effects of solifenacin (SS) and posterior tibial nerve stimulation (PTNS) treatments in multiple sclerosis (MS) patients with overactive bladder (OAB). The results showed that the SS group had better improvement in urinary incontinence after 12 weeks, higher treatment satisfaction, and decreased daytime frequency compared to the PTNS group. In conclusion, SS was more effective in improving OAB symptoms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
Katelyn Smithling Kopcsay, Tara Doyle Marczak, Peter C. Jeppson, Anne P. Cameron, Rose Khavari, Eshetu Tefera, Robert E. Gutman
Summary: This study compared the efficacy of BTX and PTNS in women with rOAB, and found that BTX treatment resulted in significantly greater improvement in urgency and UUI. However, there was no difference in success based on overall impression and OABq-SSS score.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Review
Medicine, Research & Experimental
Martina Pericolini, Gabriel Miget, Claire Hentzen, Enrico Finazzi Agro, Camille Chesnel, Philippe Lagnau, Rebecca Haddad, Matthieu Grasland, Gerard Amarenco
Summary: Neuromodulation and electrostimulation techniques are effective and safe options for managing urinary symptoms in MS patients, with PTNS and SNM showing promising results for treating overactive bladder symptoms.
Article
Medicine, General & Internal
Connor McPhail, Robert Carey, Sidharth Nambiar, Nadia Willison, Saghi Bahadori, Pouria Aryan, Tran Nguyen, Fariba Behnia-Willison
Summary: A study in Australia found that percutaneous tibial nerve stimulation (PTNS) can effectively alleviate the symptoms of overactive bladder (OAB) syndrome. For patients with OAB who do not respond to conservative treatment or wish to avoid surgery, PTNS may be an effective second-line treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)