The use of non-steroidal anti-inflammatory drugs (NSAIDs) in COVID-19

Early in the COVID-19 pandemic, anecdotal reports emerged suggesting non-steroidal anti-inflammatory drugs (NSAIDs) may increase susceptibility to infection and adversely impact clinical outcomes. This narrative literature review (March 2020-July 2021) attempted to clarify the relationship between NSAID use and COVID-19 outcomes related to disease susceptibility or severity. Twenty-four relevant publications (covering 25 studies) reporting original research data were identified; all were observational cohort studies, and eight were described as retrospective. Overall, these studies are consistent in showing that NSAIDs neither increase the likelihood of SARS-CoV-2 infection nor worsen outcomes in patients with COVID-19. This is reflected in current recommendations from major public health authorities across the world, which support NSAID use for analgesic or antipyretic treatment during COVID-19. Thus, there is no basis on which to restrict or prohibit use of these drugs by consumers or patients to manage their health conditions and symptoms during the pandemic.

Automated summary

This narrative literature review examined the relationship between NSAID use and COVID-19 outcomes. The findings indicate that NSAIDs do not increase the risk of SARS-CoV-2 infection or worsen outcomes in patients with COVID-19. Current recommendations from major public health authorities support the use of NSAIDs for pain relief and fever reduction during the pandemic.