Article
Multidisciplinary Sciences
Reetu R. Singh, Zoe McArdle, Harshil Singh, Lindsea C. Booth, Clive N. May, Geoffrey A. Head, Karen M. Moritz, Markus P. Schlaich, Kate M. Denton
Summary: Chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion, and reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in hypertensive CKD.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Alissa A. Frame, Kayla M. Nist, Kiyoung Kim, Jill T. Kuwabara, Richard D. Wainford
Summary: This study suggests that the renal sympathetic nerves, mediated by the alpha(1)-adrenoceptors, play a critical role in the natriuretic and sympathoinhibitory responses to acute increases in total body sodium, independent of blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Zoe Mcardle, Reetu R. Singh, Karen M. Moritz, Michiel F. Schreuder, Kate M. Denton
Summary: A study investigated the effects of brief postnatal ACE inhibition (ACEi) in sheep with a solitary functioning kidney (SFK). It was found that ACEi in SFK sheep led to attenuated water homeostasis in response to a physiological challenge at 20 months of age. Further studies are needed to determine the long-term effects of ACEi in children with SFK on fluid homeostasis.
Review
Biochemistry & Molecular Biology
Aleksandra Sedzikowska, Leszek Szablewski
Summary: The kidney plays a crucial role in glucose homeostasis by releasing glucose into the blood stream using carrier proteins for transport. Mutations in genes encoding glucose transporters can lead to renal disorders, impacting glucose transport and renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Jesse D. Moreira, Kayla M. Nist, Casey Y. Carmichael, Jill T. Kuwabara, Richard D. Wainford
Summary: The brain G alpha i(2) subunit proteins play a crucial role in maintaining sodium homeostasis and blood pressure. The sensory renal nerves are mechanistically involved in driving the up-regulation and activation of PVN G alpha i(2) protein pathways, while the AV3V region is not directly involved in this process.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Plant Sciences
Ankita Mohanty, Koushik Chakraborty, Subhankar Mondal, Priyanka Jena, Rajendra K. Panda, Kailash C. Samal, Krishnendu Chattopadhyay
Summary: This study investigates the variability of rice tolerance to salinity stress at the seedling and reproductive stages, and the influence of ion exclusion and tissue tolerance on salt tolerance. The results reveal that ion exclusion alone is sufficient for seedling stage tolerance, while a balance between ion exclusion and tissue tolerance is crucial for prolonged salt tolerance at the reproductive stage.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Multidisciplinary
Cecilia Herrero, Michael De San Feliciano, Samy Merabia, Laurent Joly
Summary: This paper proposes a general model for thermo-osmosis in charged nanofluidic channels, considering hydrodynamic slip and different solvent and solute contributions. By studying wetting, salt type and concentration, and surface charge, the model is applied to a wide range of systems, showing potential for generating intense thermo-osmotic flows using slipping charged surfaces and predicting behavior transitions based on surface charge and salt concentration. This theoretical framework opens up possibilities for controlling thermally induced flows with common charged surfaces and salt.
Article
Chemistry, Multidisciplinary
Dong-Hun Choi, Joon-Yong Cho, Jung-Hoon Koo, Tae-Kyung Kim
Summary: The study showed that consuming an electrolyte drink before and after exhaustive exercise can increase the body's water retention capacity, improve exercise ability, and reduce exercise-related fatigue.
APPLIED SCIENCES-BASEL
(2021)
Review
Urology & Nephrology
Forough Chelangarimiyandoab, Priyanka Mungara, Manav Batta, Emmanuelle Cordat
Summary: Urinary tract infections are common in women, with more than 1 in 2 women experiencing it at some point in their lives. A significant proportion of these patients carry antibiotic-resistant strains, emphasizing the need for alternative treatments. This review focuses on the role of collecting duct intercalated cells in bacterial clearance in the urinary tract, highlighting the potential for new therapeutic strategies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Plant Sciences
Vadim Volkov, Heiner Schwenke
Summary: This review summarizes the current knowledge on root exudation phenomenon, highlighting the changes in understanding over time due to experimental opportunities and new ideas from various knowledge areas. Recent advances in ion and water transport research at the molecular level suggest potential future directions for understanding root exudation.
Article
Endocrinology & Metabolism
Leticia Maria de Souza Cordeiro, Lauren Bainbridge, Nagavardhini Devisetty, David H. McDougal, Dorien J. M. Peters, Kavaljit H. Chhabra
Summary: This study found that knocking out Glut2 in the kidneys can reverse hyperglycemia and normalize body weight in mouse models of diabetes and obesity. The results also revealed a novel crosstalk between renal GLUT2 and SGLT2 in regulating systemic glucose homeostasis.
Article
Urology & Nephrology
Vittoria Matafora, Chiara Lanzani, Laura Zagato, Paolo Manunta, Miriam Zacchia, Francesco Trepiccione, Marco Simonini, Giovambattista Capasso, Angela Bachi
Summary: The study found that salt-sensitive patients have different urinary proteome changes compared to salt-resistant patients during salt load, particularly in regulating the renin-angiotensin system (RAS) and proteins involved in regulating epithelial sodium channel ENaC activity. Salt-sensitive and salt-resistant subjects exhibit similar responses to saline/volume infusion, but key molecules identified for salt-sensitivity include glutamyl aminopeptidase (ENPEP), PLAU, EGF, and Xaa-Pro aminopeptidase 2 precursor XPNPEP2 through modulation of ENaC-dependent sodium reabsorption along the distal tubule.
JOURNAL OF NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Robert M. Carey, Helmy M. Siragy, John J. Gildea, Susanna R. Keller
Summary: Angiotensin II (Ang II) type-2 receptors (AT(2)R) in the kidney play a crucial role in opposing renal sodium retention induced by Ang II stimulation of Ang II type-1 receptors (AT(1)R). AT(2)Rs induce natriuresis through the activation of bradykinin, nitric oxide, and cyclic GMP signaling cascade. Defects in AT(2)R activation and protein phosphatase 2A (PP2A) in spontaneously hypertensive rats are associated with primary hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Yanlin Guo, Taotao Luo, Guixiang Xie, Xiaoyan Zhang
Summary: The kidney plays a crucial role in maintaining water and electrolyte balance, with aquaporins being important for water reabsorption. Bile acid receptors have a critical role in urine concentration and show potential therapeutic value for kidney diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yohan Bignon, Leonore Wigger, Camille Ansermet, Benjamin D. Weger, Sylviane Lagarrigue, Gabriel Centeno, Fanny Durussel, Lou Gotz, Mark Ibberson, Sylvain Pradervand, Manfredo Quadroni, Meltem Weger, Francesca Amati, Frederic Gachon, Dmitri Firsov
Summary: Rhythmic adaptations in renal metabolism are suggested by circadian rhythmicity in renal function. By studying diurnal changes in renal metabolic pathways, we found that a significant number of RNAs, proteins, and metabolites in the kidneys of control mice display rhythmicity. Disruptions in key metabolic pathways were observed in the kidneys of mice with an inducible deletion of the circadian clock regulator Bmal1, resulting in impaired mitochondrial activity. The reabsorption of carnitine from primary urine was particularly affected, leading to decreased plasma and tissue carnitine levels.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Mathematics, Applied
Tarik Aougab, Margaret Beck, Paul Carter, Surabhi Desai, Bjorn Sandstede, Melissa Stadt, Aric Wheeler
JOURNAL OF DYNAMICS AND DIFFERENTIAL EQUATIONS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Melissa Stadt, Anita Layton
Review
Biology
Stephanie Abo, Delaney Smith, Melissa Stadt, Anita Layton
Summary: Men and women exhibit differences not only in reproductive systems and behaviors, but also in other organs and physiological systems. Understanding the effects of sex hormones, menstrual cycles, and pregnancy on physiological function is crucial for developing effective sex-specific therapies.
JOURNAL OF THEORETICAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Melissa M. Stadt, Jessica Leete, Sophia Devinyak, Anita T. Layton
Summary: Maintaining normal potassium concentrations is crucial for cell function. Kidneys and regulatory mechanisms, such as aldosterone and gastrointestinal feedback control, play a role in long-term potassium homeostasis. A hypothesized muscle-kidney cross talk signal may also affect potassium excretion. A compartmental model was developed to study the impact of regulatory mechanisms on potassium homeostasis, revealing the importance of these mechanisms in maintaining normal potassium concentrations.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Meeting Abstract
Physiology
Melissa Stadt, Todd Alexander, Anita Layton
Article
Multidisciplinary Sciences
Melissa M. Stadt, Crystal A. West, Anita T. Layton
Summary: Throughout pregnancy, the kidneys undergo significant adaptations to support a healthy pregnancy, such as morphological changes and altered transporters. This study aims to analyze the impact of inhibiting critical transporters on kidney function during pregnancy and chronic hypertension. Computational models were developed to simulate the effects of various changes on Na+ and K+ transport, including the activity of specific transporters. The simulation results predicted the essential role of ENaC and H+-K+-ATPase transporters in Na+ and K+ reabsorption during pregnancy, and highlighted the similar shift in Na+ transport in the presence of hypertension.
Article
Physiology
Melissa M. Stadt, Anita T. Layton
Summary: Normal pregnancy is characterized by changes in plasma volume and electrolyte retention. This study uses computational models to understand how the kidney adapts to meet the volume and electrolyte requirements during different stages of pregnancy. The results also suggest that known sex differences in renal transporter pattern may help females better prepare for the increased transport demand during pregnancy.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)