Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1026386
Keywords
platelets; platelet extracellular vesicles; drug-loaded; targeted drug delivery; inflammation; tumors
Categories
Funding
- National Key R&D Program of China
- National Nature Science Fund of China
- Natural Science Fund of Zhejiang Province
- Innovative Talent Support Program Project of Zhejiang Provincial Health Commission
- Public Projects of Zhejiang Province
- Zhejiang Provincial Program for the cultivation of high-level innovative health talents
- [2020YFC1107104]
- [82072414]
- [81802147]
- [81772387]
- [LY21H060002]
- [2021433298]
- [LGF19H060013]
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Platelets are blood cells produced by megakaryocytes and play important roles in various physiological and pathological processes. Drug-loaded platelet therapies have advantages in targeted drug delivery due to their better targeting, biocompatibility, and lower immunogenicity. Recent studies suggest that platelet extracellular vesicles (PEVs) have even more advantages. PEVs, the most abundant vesicles in blood, exhibit functional characteristics similar to platelets and enhance the therapeutic benefits of targeted drug delivery.
Platelets are blood cells that are primarily produced by the shedding of megakaryocytes in the bone marrow. Platelets participate in a variety of physiological and pathological processes in vivo, including hemostasis, thrombosis, immune-inflammation, tumor progression, and metastasis. Platelets have been widely used for targeted drug delivery therapies for treating various inflammatory and tumor-related diseases. Compared to other drug-loaded treatments, drug-loaded platelets have better targeting, superior biocompatibility, and lower immunogenicity. Drug-loaded platelet therapies include platelet membrane coating, platelet engineering, and biomimetic platelets. Recent studies have indicated that platelet extracellular vesicles (PEVs) may have more advantages compared with traditional drug-loaded platelets. PEVs are the most abundant vesicles in the blood and exhibit many of the functional characteristics of platelets. Notably, PEVs have excellent biological efficacy, which facilitates the therapeutic benefits of targeted drug delivery. This article provides a summary of platelet and PEVs biology and discusses their relationships with diseases. In addition, we describe the preparation, drug-loaded methods, and specific advantages of platelets and PEVs targeted drug delivery therapies for treating inflammation and tumors. We summarize the hot spots analysis of scientific articles on PEVs and provide a research trend, which aims to give a unique insight into the development of PEVs research focus.
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