Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance

Immune Resistance in Lung Adenocarcinoma

(2021) Magda Spella et al.   Cancers

PSMC2, ORC5 and KRTDAP are specific biomarkers for HPV‑negative head and neck squamous cell carcinoma

(2021) Yushen Su et al.   Oncology Letters

Pancancer survival analysis of cancer hallmark genes

(2021) Ádám Nagy et al.   Scientific Reports

The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

(2021) Yan Chen et al.   Frontiers in Oncology

Identification of Biomarkers Related to CD8+ T Cell Infiltration With Gene Co-expression Network in Lung Squamous Cell Carcinoma

(2021) Min Tang et al.   Frontiers in Cell and Developmental Biology

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value

(2021) Yukun Li et al.   Frontiers in Oncology

mRNAsi Index: Machine Learning in Mining Lung Adenocarcinoma Stem Cell Biomarkers

(2020) Yitong Zhang et al.   Genes

Integrative Analysis of MicroRNA and Gene Interactions for Revealing Candidate Signatures in Prostate Cancer

(2020) Jingchao Wei et al.   Frontiers in Genetics

TIMER2.0 for analysis of tumor-infiltrating immune cells

(2020) Taiwen Li et al.   NUCLEIC ACIDS RESEARCH

A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins

(2020) Etsuko Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

(2020) Enkhtsetseg Munkhbaatar et al.   Nature Communications

Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1

(2019) Xing Chen et al.   Cancer Cell International

Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial

(2019) Tony S K Mok et al.   LANCET

GENT2: an updated gene expression database for normal and tumor tissues

(2019) Seung-Jin Park et al.   BMC Medical Genomics

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

(2019) Philippe Coulombe et al.   Nature Communications

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue

(2019) Rui-Sheng Zhou et al.   BMC CANCER

Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway

(2019) Wenmin Xiong et al.   MOLECULAR AND CELLULAR PROBES

Identification of the ORC Complex Subunits That Can Interact with the ENY2 Protein of Drosophila melanogaster

(2018) O. G. Maksimenko et al.   Doklady Biochemistry and Biophysics

Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression

(2018) Kentaro Inamura   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eukaryotic DNA replication: Orchestrated action of multi-subunit protein complexes

(2018) Sukhyun Kang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

DNA replication licensing proteins: Saints and sinners in cancer

(2018) Muhammad Jameel Mughal et al.   SEMINARS IN CANCER BIOLOGY

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

Inconsistent Results With Different Secondary Reflex Assays for ResolvingHER2Status

(2016) Carlynn Willmore-Payne et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Lung Adenocarcinoma Staging Using the 2011 IASLC/ATS/ERS Classification: A Pooled Analysis of Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma

(2016) Madhusmita Behera et al.   Clinical Lung Cancer

SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability

(2016) Chao Huang et al.   Cell Reports

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

ORC proteins in the mammalian zygote

(2015) Michael A. Ortega et al.   CELL AND TISSUE RESEARCH

Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner

(2015) Sumanprava Giri et al.   JOURNAL OF CELL SCIENCE

Crystal structure of the eukaryotic origin recognition complex

(2015) Franziska Bleichert et al.   NATURE

The expression of TTF-1 and Napsin A in early-stage lung adenocarcinoma correlates with the results of surgical treatment

(2015) Yunfan Ma et al.   TUMOR BIOLOGY

Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

(2015) Katarzyna Tomczak et al.   Wspolczesna Onkologia-Contemporary Oncology

Localization of ORC1 During the Cell Cycle in Human Leukemia Cells

(2015) Frederick D. Coffman et al.   Analytical Cellular Pathology

MicroRNA-26a/b Regulate DNA Replication Licensing, Tumorigenesis, and Prognosis by Targeting CDC6 in Lung Cancer

(2014) Xin Zhang et al.   MOLECULAR CANCER RESEARCH

Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer

(2012) B. Song et al.   MOLECULAR CANCER THERAPEUTICS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Schizosaccharomyces pombeOrc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle

(2011) Hiroaki Kato et al.   CELL CYCLE

Assembly of the Human Origin Recognition Complex Occurs through Independent Nuclear Localization of Its Components

(2011) Soma Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization

(2010) S. G. Prasanth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DnaA and ORC: more than DNA replication initiators

(2010) Graham Scholefield et al.   TRENDS IN CELL BIOLOGY

Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders

(2009) Milica Radojkovic et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Orc1 Controls Centriole and Centrosome Copy Number in Human Cells

(2009) A. S. Hemerly et al.   SCIENCE

Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres

(2008) Yasutoshi Tatsumi et al.   GENES TO CELLS

Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 inSaccharomyces cerevisiae

(2008) Junsuo Kan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin

(2008) Elaine J. Gavin et al.   PLoS One