Article
Medicine, General & Internal
Guoju Li, Yuhan Xing, Guolan Wang, Jun Zhang, Qin Wu, Wei Ni, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Zhenhong Zhang, Yao Wang, Quansheng Xing
Summary: The study revealed a negative association between maternal pre-pregnancy low BMI and macrosomia, with varying protective effects based on maternal age and parity. Low BMI showed the most prominent protective effect against macrosomia in nulliparous mothers aged 35 years and above, and multiparous mothers younger than 25 years old.
Review
Medicine, Research & Experimental
Duaa Ahmed Elhag, Souhaila Al Khodor
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. They have been found to be involved in the pathogenesis of gestational diabetes mellitus (GDM), and their aberrant expression in the placenta and/or maternal blood suggests their potential as biomarkers for early diagnosis and prognosis. Additionally, miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM, and their potential as diagnostic and therapeutic targets.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Xinli Song, Letao Chen, Senmao Zhang, Yiping Liu, Jianhui Wei, Tingting Wang, Jiabi Qin
Summary: The study found that gestational diabetes mellitus and high maternal triglyceride levels independently increased the risk of macrosomia, and collectively acted as significant mediators in the relationship between pre-pregnancy overweight/obesity and macrosomia.
Article
Nutrition & Dietetics
Andrzej Miturski, Tomasz Geca, Aleksandra Stupak, Wojciech Kwasniewski, Anna Semczuk-Sikora
Summary: Higher BMI before pregnancy is associated with increased risk of maternal and perinatal complications. This study found that pregestational obesity does not significantly affect carbohydrate metabolism in pregnant women, but it does disturb lipid profile, resulting in increased triglycerides and decreased HDL cholesterol levels. Obesity also increases leptin and resistin concentrations in pregnant women's serum, which may be caused by increased adipose tissue volume. The concentration of leptin in umbilical cord blood is positively correlated with birth weight, suggesting its contribution to the pathomechanism of macrosomia.
Article
Nutrition & Dietetics
Xinli Song, Letao Chen, Senmao Zhang, Yiping Liu, Jianhui Wei, Mengting Sun, Jing Shu, Tingting Wang, Jiabi Qin
Summary: This study aimed to investigate the relationship between maternal pre-pregnancy overweight/obesity, high maternal triglyceride levels, and the risk of macrosomia. The results showed that overweight/obesity had a partially mediated effect on macrosomia through high triglyceride levels, with a mediation proportion of 11.1% and 3.8%, respectively.
Article
Endocrinology & Metabolism
Hanxiang Sun, Yang Liu, Shijia Huang, Xiaosong Liu, Guohua Li, Qiaoling Du
Summary: This study investigated the association between pre-pregnancy body mass index (BMI) and adverse maternal and neonatal outcomes in singleton pregnancies after assisted reproductive technology (ART). The findings showed that women who were overweight or obese before pregnancy through ART were more likely to have a cesarean section, gestational diabetes mellitus, gestational hypertension, and preeclampsia. Moreover, neonates from women who had obesity before pregnancy through ART were more likely to have macrosomia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Felix Teufel, Jacqueline A. Seiglie, Pascal Geldsetzer, Michaela Theilmann, Maja E. Marcus, Cara Ebert, William Andres Lopez Arboleda, Kokou Agoudavi, Glennis Andall-Brereton, Krishna K. Aryal, Brice Wilfried Bicaba, Garry Brian, Pascal Bovet, Maria Dorobantu, Mongal Singh Gurung, David Guwatudde, Corine Houehanou, Dismand Houinato, Jutta M. Adelin Jorgensen, Gibson B. Kagaruki, Khem B. Karki, Demetre Labadarios, Joao S. Martins, Mary T. Mayige, Roy Wong McClure, Joseph Kibachio Mwangi, Omar Mwalim, Bolormaa Norov, Sarah Crooks, Farshad Farzadfar, Sahar Saeedi Moghaddam, Bahendeka K. Silver, Lela Sturua, Chea Stanford Wesseh, Andrew C. Stokes, Utibe R. Essien, Jan-Walter De Neve, Rifat Atun, Justine I. Davies, Sebastian Vollmer, Till W. Barnighausen, Mohammed K. Ali, James B. Meigs, Deborah J. Wexler, Jennifer Manne-Goehler
Summary: The prevalence of overweight, obesity, and diabetes is increasing rapidly in low-income and middle-income countries, with BMI affecting the risk of diabetes, but there are significant regional variations in this association.
Article
Multidisciplinary Sciences
Jie Tang, Xinhong Zhu, Yanbing Chen, Dongming Huang, Henning Tiemeier, Ruoling Chen, Wei Bao, Qingguo Zhao
Summary: This study found that in the Chinese population, maternal pre-pregnancy BMI was significantly associated with the risk of adverse pregnancy outcomes, and this risk varied according to maternal age. Further research is needed to explore whether and how counseling and interventions for women with either low or high BMI before pregnancy can reduce the risk of adverse pregnancy outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Arif Sabta Aji, Nur Indrawaty Lipoeto, Yusrawati Yusrawati, Safarina G. Malik, Nur Aini Kusmayanti, Isman Susanto, Nur Mukhlishoh Majidah, Siti Nurunniyah, Ratih Devi Alfiana, Wahyuningsih Wahyuningsih, Karani S. Vimaleswaran
Summary: This study reveals that pre-pregnancy nutritional status and inadequate or excessive gestational weight gain (GWG) are significant risk factors for adverse pregnancy outcomes. These findings emphasize the importance of providing information, preconception counseling, and health education on weight management for healthy pregnancies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Endocrinology & Metabolism
Shirin Djalalinia, Moein Yoosefi, Sarvenaz Shahin, Erfan Ghasemi, Nazila Rezaei, Naser Ahmadi, Negar Rezaei, Mehrdad Azmin, Shahabeddin Rezaei, Maryam Nasserinejad, Esmaeil Mohammadi, Rosa Haghshenas, Alireza Namazi Shabestari, Hamidreza Jamshidi, Marziyeh Vahid Dastjerdi, Bagher Larijani, Farshad Farzadfar
Summary: This study investigated the distribution of body mass index (BMI) levels in Iranian adults and found significant differences in obesity prevalence between male and female participants, as well as across different regions of the country.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Silje Malen Andreassen, Ulf Ekelund, Guro Pauck Bernhardsen
Summary: The study found that maternal exercise level during pregnancy does not seem to be associated with the child's BMI or odds of being overweight or obese in childhood, and the child's physical activity level also does not appear to affect this association.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Review
Nutrition & Dietetics
Adriana Mannino, Katerina Sarapis, George Moschonis
Summary: Maternal overweight/obesity during pre-pregnancy and childhood are both positively associated with childhood obesity, but it is uncertain which factor is a stronger predictor. Therefore, intervention programs aiming to reduce childhood obesity should focus on supporting women of childbearing age with weight management throughout their life-course.
Article
Public, Environmental & Occupational Health
Sandra Ana Czarnobay, Caroline Kroll, Cecilia Burigo Correa, Silmara S. B. S. Mastroeni, Marco F. Mastroeni
Summary: This study examined the predictors of excess body weight in mother-child pairs after delivery, and found that excessive pre-pregnancy BMI, excessive gestational weight gain, and large-for-gestational age infants were strong predictors of concurrent excess body weight in mother-child pairs. This highlights the importance of implementing targeted public policies before and during pregnancy to prevent excess body weight in both mother and child.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Dimitrios Papandreou, Maria Mantzorou, Stefanos Tyrovolas, Eleni Pavlidou, Georgios Antasouras, Evmorfia Psara, Efthymios Poulios, Georgios K. Vasios, Constantinos Giaginis
Summary: The rates of overweight and obesity are high among women of childbearing age in Greece, highlighting the urgent need for healthy lifestyle promotion and targeted obesity prevention and intervention schemes among this population.
Article
Geriatrics & Gerontology
Takaaki Ikeda, Upul Cooray, Yuta Suzuki, Anna Kinugawa, Masayasu Murakami, Ken Osaka
Summary: This study reveals the impacts of changes in obesity status on back pain risk in older populations, with heterogeneity observed according to muscle strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)