Article
Endocrinology & Metabolism
Yongjin Li, Chao Kong, Baobao Wang, Wenzhi Sun, Xiaolong Chen, Weiguo Zhu, Junzhe Ding, Shibao Lu
Summary: Lower back pain is a common reason for dyskinesia, with paraspinal muscle degeneration identified as a contributing factor. Muscle atrophy, oxidative stress, reactive oxygen species, and inflammation are all associated with this degeneration. Research on the molecular mechanisms behind paraspinal muscle degeneration could provide important insights into potential treatments.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biology
Lilla Horvath, Noemi Nemeth, Gergely Feher, Zsuzsanna Kives, Dora Endrei, Imre Boncz
Summary: The past decades have seen a significant increase in atherosclerotic cardiovascular diseases (CVDs), particularly in low-income and middle-income countries (LMICs). Peripheral artery disease (PAD), which is strongly age-related, is estimated to become more prevalent in the future. PAD shares risk factors with coronary and cerebrovascular diseases and is associated with significant morbidity and mortality. Despite advances in treatment, the prevalence of PAD continues to rise, and data from LMICs are scarce.
Article
Cardiac & Cardiovascular Systems
Caroline G. Pass, Victoria Palzkill, Jianna Tan, Kyoungrae Kim, Trace Thome, Qingping Yang, Brian Fazzone, Scott T. Robinson, Kerri A. O'Malley, Feng Yue, Salvatore T. Scali, Scott A. Berceli, Terence E. Ryan
Summary: This study presents a single-nuclei RNA-sequencing atlas of PAD limb muscle, revealing a shift in fiber type and upregulation of stress response, autophagy, hypoxia, and atrophy-related genes in PAD patients. Additionally, unique transcriptional profiles and increased diversity of transcriptomes were observed in muscle stem cells, regenerating myonuclei, and fibro-adipogenic progenitor cells of PAD muscles. Analysis of intercellular communication networks highlighted fibro-adipogenic progenitors as a major signaling hub in PAD muscle, along with deficiencies in angiogenic and bone morphogenetic protein signaling which could contribute to poor limb function in PAD.
CIRCULATION RESEARCH
(2023)
Article
Cell Biology
Yaqing Zhou, Sheng Zhang, Wenfeng Ji, Xiongkang Gan, Lei Hua, Can Hou, Jiaxin Chen, Yanjun Wang, Shu He, Hanxiao Zhou, Enzhi Jia
Summary: This study identified differentially expressed lncRNAs and mRNAs in atherosclerosis through RNA sequencing and validated their roles in smooth muscle cells, providing new targets for the diagnosis and treatment of atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Jingxuan Han, Lailiu Luo, Olivia Marcelina, Vivi Kasim, Shourong Wu
Summary: Peripheral artery disease (PAD) poses a significant challenge to society and its prevalence is expected to increase in the coming years. Patients in severe stages of PAD are at high risk of amputation and death, leading to decreased quality of life and socio-economic burden. Therapeutic angiogenesis has emerged as a potential strategy for treating PAD, but further efforts are needed to address certain issues.
Article
Cardiac & Cardiovascular Systems
Luigi Ferrucci, Julian Candia, Ceereena Ubaida-Mohien, Alexey Lyashkov, Nirad Banskota, Christiaan Leeuwenburgh, Stephanie Wohlgemuth, Jack M. Guralnik, Mary Kaileh, Dongxue Zhang, Robert Sufit, Supriyo De, Myriam Gorospe, Rachel Munk, Charlotte A. Peterson, Mary M. McDermott
Summary: Transcriptomic and proteomic analyses revealed activation of hypoxia-compensatory mechanisms, inflammation, fibrosis, apoptosis, angiogenesis, unfolded protein response, and nerve and muscle repair in peripheral artery disease (PAD) muscle. Aberrant proportions of mitochondrial respiratory proteins and reduced activity of rate-limiting glycolytic enzymes were also observed. These mechanisms may serve as potential targets for disease modification.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Svetlana Shikhevich, Irina Chadaeva, Bato Khandaev, Rimma Kozhemyakina, Karina Zolotareva, Anna Kazachek, Dmitry Oshchepkov, Anton Bogomolov, Natalya V. Klimova, Vladimir A. Ivanisenko, Pavel Demenkov, Zakhar Mustafin, Arcady Markel, Ludmila Savinkova, Nikolay A. Kolchanov, Vladimir Kozlov, Mikhail Ponomarenko
Summary: Mainstream transcriptome profiling of susceptibility versus resistance to age-related diseases (ARDs) focuses on differentially expressed genes (DEGs) specific to gender, age, and pathogeneses. In this study, the periaqueductal gray (PAG) transcriptome of tame versus aggressive rats was sequenced and compared with known ARD-linked DEGs in animals. The analysis revealed significant correlations between behavior-related DEGs and ARD-susceptibility-related DEGs. With human ARD susceptibility and resistance DEGs as controls, a common molecular marker for ARDs was identified: excess expression of Fc gamma receptor IIb suppressing immune cell hyperactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Isma N. Javed, Beau M. Hawkins
Summary: Aorto-iliac disease is a common manifestation of atherosclerosis, with treatment options including medication, risk factor modification, exercise, and revascularization for severe cases. Various endovascular therapies are now available for complex lesions.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Multidisciplinary Sciences
Changsheng Guo, Yuanqing Hua, Zuanhao Qian
Summary: This study identified differentially expressed lncRNAs and genes in Kawasaki disease (KD), as well as constructed ceRNA networks involving miRNAs and mRNAs. The study found specific lncRNAs (PSORS1C3, LINC00999, SNHG5) and genes (GATA3, SOD2, MAPK14, PPARG) that may play a key role in the pathogenesis and development of KD. Validation in a separate dataset showed that intravenous immunoglobulin treatment alleviated the deregulated RNA profiles in KD patients.
Article
Genetics & Heredity
Jiahong Sun, Xiaodong Tan, Xinting Yang, Lu Bai, Fuli Kong, Guiping Zhao, Jie Wen, Ranran Liu
Summary: This study identifies candidate genes associated with chicken meat color by comparing fast-growing, white-feathered chickens and slow-growing, yellow-feathered chickens. The findings contribute to the understanding of the molecular mechanisms regulating meat color and the development of molecular markers for chicken meat color selection.
Article
Biology
Sukanta Bhadra, Siyu Chen, Chang Liu
Summary: Depression is a major global health burden affecting millions of people worldwide. Studies have found complex associations between depression and metabolic disorders, identifying common differentially expressed genes.
Article
Agriculture, Dairy & Animal Science
Wenqian Jia, Lei Wu, Zhong Zhuang, Minghong Xu, Yijia Lu, Zhixiu Wang, Hao Bai, Guohong Chen, Guobin Chang, Yong Jiang
Summary: This study investigated the molecular mechanism of threonine regulation on breast muscle development in Pekin ducks. The results showed that threonine intake level affected body weight and breast fiber size in Pekin ducks, and regulated the expression of many genes. This study provides new insights into the molecular mechanisms underlying breast muscle development in ducks.
Article
Plant Sciences
Jijun Li, Sidra Iqbal, Yuting Zhang, Yahui Chen, Zengdong Tan, Usman Ali, Liang Guo
Summary: The comparative transcriptome analysis in two rapeseed lines under flooding stress reveals that transcription regulation and antioxidant activity are common response processes in rapeseed flooding. These processes may contribute to rapeseed flooding resistance.
Article
Surgery
Tucker D. Avra, Monica Le, Stephanie Hernandez, Katie Thure, Jesus G. Ulloa
Summary: This study evaluates the readability of online patient education materials on peripheral artery disease (PAD). The findings show that these resources are generally written at a higher level than the recommended reading level. It is suggested that hospitals, professional societies, and other stakeholders in PAD patient education consider the readability of their materials to improve accessibility in healthcare.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Genetics & Heredity
Fawad Ali, Arifullah Khan, Syed Aun Muhammad, Syed Shams Ul Hassan
Summary: This study utilized an integrated system-level framework to explore differentially expressed genes (DEGs) contributing to hypertension pathophysiology. Seven hypertension-related genes were identified, and their aberrant expression was found to be associated with pathological development and cardiovascular abnormalities of hypertension.
Article
Cardiac & Cardiovascular Systems
Daniel Perez-Cremades, Jingshu Chen, Carmel Assa, Mark W. Feinberg
Summary: Diabetes mellitus is a global public health problem that is expected to continue increasing due to the rise in obesity and aging population. Individuals with diabetes have a higher risk of cardiovascular complications, particularly myocardial infarction (MI). In the past two decades, studies have revealed the role of stage-specific miRNAs in the hearts of people with diabetes and MI, impacting cardiomyocyte death, angiogenesis, inflammatory response, myocardial remodeling, and myocardial lipotoxicity. Understanding the significance of these miRNAs and their targets may lead to novel RNA-based therapeutic interventions for managing the increased risk of MI in diabetes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Michael G. McCoy, Anurag Jamaiyar, Grasiele Sausen, Henry S. Cheng, Daniel Perez-Cremades, Rulin Zhuang, Jingshu Chen, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca, Mark W. Feinberg
Summary: Peripheral artery disease (PAD) is a serious condition that can lead to limb loss and death, especially in subjects with diabetes. In this study, researchers identified miR-375 as a potential therapeutic target for critical limb ischemia (CLI), an advanced form of PAD. They found that miR-375, when overexpressed, promotes angiogenesis and arteriogenesis, improving blood flow recovery in diabetic mice. Further investigation revealed that miR-375 regulates the NF-kB signaling pathway by targeting Kruppel-like factor 5 (KLF5). These findings suggest that targeting the miR-375-KLF5-NF-kB signaling axis may be an effective strategy for treating CLI in diabetes.
Article
Clinical Neurology
Marian Shahid, Ashley Rawls, Veronica Ramirez, Sephira Ryman, Veronica E. Santini, Laurice Yang, Sharon J. Sha, Jacob N. Hall, Thomas J. Montine, Amy Lin, Lu Tian, Victor W. Henderson, Brenna Cholerton, Maya Yutsis, Kathleen L. Poston
Summary: This study aimed to investigate pareidolias in patients across the Lewy body disease spectrum. Illusory responses were studied in 300 participants, and it was found that cognitively impaired LB patients were more likely to endorse illusory responses compared to other groups. The Noise Pareidolia Task can be used to screen for unobtrusive pareidolias in LB patients before the onset of hallucinations and delusions.
ANNALS OF NEUROLOGY
(2023)
Article
Biology
Rex Shen, Keran Moll, Ying Lu, Lu Tian
Summary: Post-market active safety monitoring is crucial for timely detection of safety signals. Group sequential analysis is commonly used, but has limitations. In this study, a new method accounting for seasonality and variation from historical controls is proposed, along with a confidence interval to quantify vaccine safety. Real-data examples and simulation studies support the efficacy of this approach.
Article
Pharmacology & Pharmacy
Jeen Liu, Jane Zhang, Alan Mitchell, Mindy Fang, Lu Tian
Summary: The use of historical data has been a popular topic recently, as it is believed to offer a way to lessen patient burden, decrease drug development costs, and provide innovative therapies to patients earlier. This paper proposes a doubly robust adjustment procedure specifically designed for longitudinal data analysis with missing data. Extensive numerical studies and application to real clinical trial data comparing with historical data demonstrate the effectiveness of the proposed method.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Article
Biochemistry & Molecular Biology
Daniel Perez-Cremades, Carlos Bueno-Beti, Jose Luis Garcia-Gimenez, Jose Santiago Ibanez-Cabellos, Federico Pallardo, Carlos Hermenegildo, Susana Novella
Summary: This study reveals that extracellular histones can increase endothelial cell activation by increasing cytosolic reactive oxygen species production and triggering the overexpression of cell adhesion molecules. The study also identifies cyclooxygenase and NADPH oxidase as sources of reactive oxygen species production. These findings enhance our understanding of how extracellular histones contribute to systemic inflammatory responses in diseases.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Picca, Stephanie E. Wohlgemuth, Mary M. McDermott, Sunil K. Saini, Sudarshan Dayanidhi, Dongxue Zhang, Shujun Xu, Kate Kosmac, Lu Tian, Luigi Ferrucci, Robert L. Sufit, Emanuele Marzetti, Christiaan Leeuwenburgh
Summary: Mitochondrial abnormalities in gastrocnemius muscle are associated with peripheral artery disease (PAD). This study investigated the relationship between mitochondrial biogenesis and autophagy and ischemia severity and walking impairment in PAD patients. The results showed that the abundance of mitochondrial electron transport chain complexes was higher in patients with greater ischemia, and higher ischemia severity was also associated with increased autophagy markers. These abnormalities may contribute to the walking impairment in PAD patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, Research & Experimental
Henry S. Cheng, Rulin Zhuang, Daniel Perez-Cremades, Jingshu Chen, Anurag Jamaiyar, Winona Wu, Grasiele Sausen, Aspasia Tzani, Jorge Plutzky, Jorge Henao-Mejia, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca, Mark W. Feinberg
Summary: Patients with peripheral artery disease (PAD) and diabetes have a high risk of critical limb ischemia (CLI) and amputation. Dysregulated miRNAs from diabetic individuals with PAD and diabetic mice with limb ischemia revealed conserved miR-181 family members. High-fat-fed, diabetic Mir181a2b2-KO mice had impaired revascularization due to abrogation of circulating Ly6Chi monocytes. M2-like KO macrophages under diabetic conditions failed to produce proangiogenic cytokines.
Article
Developmental Biology
Agnieszka Kalinowski, Lu Tian, Reenal Pattni, Hanna Ollila, Maroof Khan, Cindy Manko, Melissa Silverman, Meiqian Ma, Laurie Columbo, Bahare Farhadian, Susan Swedo, Tanya Murphy, Mats Johnson, Elisabeth Fernell, Christopher Gillberg, Margo Thienemann, Elizabeth D. Mellins, Douglas F. Levinson, Alexander E. Urban, Jennifer Frankovich
Summary: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a sudden-onset neuropsychiatric disorder with an increased prevalence of co-morbid autoimmune illness, particularly arthritis. PANS patients with low C4B copy number are at higher risk for subsequent Juvenile Idiopathic Arthritis (JIA) diagnosis. There is a possible association between low C4B and PANS age of onset, suggesting a potential role of C4B in different types of arthritis.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Immunology
Hector Bonilla, Lu Tian, Vincent C. Marconi, Robert Shafer, Grace A. Mccomsey, Mitchel Miglis, Philip Yang, Andres Bonilla, Lauren Eggert, Linda N. Geng
Summary: The global prevalence of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) is approximately 43%, while in the United States, around 11% of individuals who have been infected with SARSCoV-2 experience long COVID. The underlying causes of PASC are still under investigation, and there are currently no FDA-approved therapies. Naltrexone, a medication with anti-inflammatory and immunomodulatory properties, has shown potential as a therapeutic intervention for PASC, but further rigorous clinical trials are needed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Letter
Oncology
Zachary R. Mccaw, Lu Tian, Lee-Jen Wei
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Xiaotong Jiang, Gabrielle Simoneau, Mel Zuercher, Yanic Heer, Philip van Hoevell, Adrian Harrington, Wanda Castro-Borrero, Carl de Moor, Fabio Pellegrini, Lu Tian, Arnfin Bergmann, Stefan Braune
Summary: This retrospective study assessed the overall and patient-specific effects of dimethyl fumarate (DMF) versus teriflunomide (TERI) in patients with relapsing-remitting multiple sclerosis (MS). The study utilized a precision medicine scoring approach and found that DMF had superior effectiveness in reducing relapse-related endpoints compared to TERI. Furthermore, the study identified a subgroup of patients for whom DMF was more effective than TERI.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Xuan Wang, Brian Lee Claggett, Lu Tian
Meeting Abstract
Peripheral Vascular Disease
Mary O. Whipple, Lihui Zhao, Lu Tian, Dongxue Zhang, Mary M. McDermott
Meeting Abstract
Peripheral Vascular Disease
Nina C. Byskosh, Lu Tian, Lihui Zhao, Dongxue Zhang, Mary M. McDermott