☆ 4.8 Article

Experience-driven rate modulation is reinstated during hippocampal replay

ELIFE (2022)

Journal

ELIFE

Volume 11, Issue -, Pages -

Publisher

eLIFE SCIENCES PUBL LTD

DOI: 10.7554/eLife.79031

Keywords

replay; hippocampus; sleep; memory consolidation; neural coding; place cell; Rat

Categories

Biology

Funding

Biotechnology and Biological Sciences Research Council scholarship [BB/M009513/1]
European Research Council starter grant (CHIME)
Human Frontiers Science Program Young Investigator Award [RGY0067/2016]
Biotechnology and Biological Sciences Research Council [BB/T005475/1]

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Abstract

In the dorsal CA1 region of rats, place cells can modulate their firing rate to discriminate between different contexts, independent of place information.

Replay, the sequential reactivation within a neuronal ensemble, is a central hippocampal mechanism postulated to drive memory processing. While both rate and place representations are used by hippocampal place cells to encode behavioral episodes, replay has been largely defined by only the latter - based on the fidelity of sequential activity across neighboring place fields. Here, we show that dorsal CA1 place cells in rats can modulate their firing rate between replay events of two different contexts. This experience-dependent phenomenon mirrors the same pattern of rate modulation observed during behavior and can be used independently from place information within replay sequences to discriminate between contexts. Our results reveal the existence of two complementary neural representations available for memory processes.

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