Prenatal alcohol exposure causes persistent microglial activation and age- and sex- specific effects on cognition and metabolic outcomes in an Alzheimer’s Disease mouse model

Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer’s Disease

(2022) Steven G. Fagan et al.   MOLECULAR NEUROBIOLOGY

Alcohol Consumption and Binge Drinking During Pregnancy Among Adults Aged 18–49 Years — United States, 2018–2020

(2022) Lucas K. Gosdin et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders

(2022) Nipun Saini et al.   Nutrients

Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse

(2022) Susan M. Smith et al.   Nutrients

Anti-Diabetic Effects of Allium hookeri Extracts Prepared by Different Methods in Type 2 C57BL/J-db/db Mice

(2022) Ji-Hye Choi et al.   Pharmaceuticals

Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease

(2022) Yetirajam Rajesh et al.   Cells

Alterations in Insulin Levels in Adults with Prenatal Alcohol Exposure

(2021) JA Kable et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder

(2021) Manjot S. Virdee et al.   Scientific Reports

Growth and behavioral differences in a C57BL/6J mouse model of prenatal alcohol exposure

(2021) Sandra M. Mooney et al.   ALCOHOL

Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood

(2020) Olivia Weeks et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice

(2020) Amy Christensen et al.   Frontiers in Aging Neuroscience

Molecular basis of ageing in chronic metabolic diseases

(2020) R. Spinelli et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

(2020) Lisa S. Robison et al.   Journal of Neuroinflammation

Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders

(2020) Cynthia J. M. Kane et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure

(2020) Raksha Raghunathan et al.   JOURNAL OF BIOMEDICAL OPTICS

Alcohol use and dementia: a systematic scoping review

(2019) Jürgen Rehm et al.   Alzheimers Research & Therapy

Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism

(2019) Lucy G. Chastain et al.   NEUROPSYCHOPHARMACOLOGY

Alzheimer disease risk genes: 29 and counting

(2019) Lars Bertram et al.   Nature Reviews Neurology

Adverse Health Outcomes in Offspring Associated With Fetal Alcohol Exposure: A Systematic Review of Clinical and Preclinical Studies With a Focus on Metabolic and Body Composition Outcomes

(2019) Lisa K. Akison et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats

(2019) Peng Wang et al.   NEUROSCIENCE LETTERS

Association Analysis: Fetal Alcohol Spectrum Disorders and Hypertension Status in Children and Adolescents

(2019) Jonathan C. Cook et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Type II Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline

(2019) Kelsey R. Thomas et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Adverse health outcomes associated with fetal alcohol exposure: A systematic review focused on immune‐related outcomes

(2019) Natasha Reid et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood

(2019) Claudia I. Aghaie et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities

(2018) Philip A. May et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging

(2018) Freddy J. Alfaro et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder

(2018) Robyn M. Amos-Kroohs et al.   PLoS One

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer’s Disease and Affects Mice with Normal Aging

(2018) Raquel Baeta-Corral et al.   Frontiers in Pharmacology

Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function

(2018) Shahani Noor et al.   Frontiers in Immunology

Metabolic Syndrome and Cognitive Decline in Early Alzheimer's Disease and Healthy Older Adults

(2018) Amber S. Watts et al.   JOURNAL OF ALZHEIMERS DISEASE

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

(2018) Ramona Belfiore et al.   AGING CELL

TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders

(2017) María Pascual et al.   Journal of Neuroinflammation

Maternal alcohol binge drinking induces persistent neuroinflammation associated with myelin damage and behavioural dysfunctions in offspring mice

(2017) Lídia Cantacorps et al.   NEUROPHARMACOLOGY

Metabolic Syndrome and Cognitive Impairment: Current Epidemiology and Possible Underlying Mechanisms

(2017) Francesco Panza et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring

(2017) Emelie M. Gårdebjer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alcohol-Induced Developmental Origins of Adult-Onset Diseases

(2016) Emilie R. Lunde et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Evidence for an immune signature of prenatal alcohol exposure in female rats

(2016) Tamara S. Bodnar et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory responses to alcohol in the CNS: nuclear receptors as potential therapeutics for alcohol-induced neuropathologies

(2016) Cynthia J. M. Kane et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder

(2016) Robyn M. Amos-Kroohs et al.   JOURNAL OF PEDIATRICS

Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders

(2015) Paul D. Drew et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease

(2015) Kurt R. Stover et al.   BEHAVIOURAL BRAIN RESEARCH

Early-Life Exposure to Substance Abuse and Risk of Type 2 Diabetes in Adulthood

(2015) A. M. Vaiserman   Current Diabetes Reports

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensitivity in rat offspring, which is exacerbated by a postnatal high-fat diet

(2015) Emelie M. Gårdebjer et al.   FASEB JOURNAL

Overweight and Obesity Among Children and Adolescents with Fetal Alcohol Spectrum Disorders

(2014) Anita J. Fuglestad et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages

(2014) Jing-Yu Yang et al.   PHARMACOLOGY & THERAPEUTICS

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

The Relationship Between Midlife and Late Life Alcohol Consumption, APOE e4 and the Decline in Learning and Memory Among Older Adults

(2013) Brian Downer et al.   ALCOHOL AND ALCOHOLISM

Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure

(2013) Rachel L. Werts et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Glucose Levels and Risk of Dementia

(2013) Paul K. Crane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of Low Dose Prenatal Ethanol Exposure on Glucose Homeostasis in Sprague-Dawley Rats Aged up to Eight Months

(2013) Megan E. Probyn et al.   PLoS One

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)

(2012) Mohammed Filali et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroimmune mechanisms in fetal alcohol spectrum disorder

(2012) Cynthia J.M. Kane et al.   Developmental Neurobiology

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-related changes in neuroactive steroid levels in 3xTg-AD mice

(2012) Donatella Caruso et al.   NEUROBIOLOGY OF AGING

Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring

(2012) C C Dobson et al.   Nutrition & Diabetes

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Midlife overweight and obesity increase late-life dementia risk: A population-based twin study

(2011) W. L. Xu et al.   NEUROLOGY

Role of neurotrophins on postnatal neurogenesis in the thalamus: prenatal exposure to ethanol

(2011) S.M. Mooney et al.   NEUROSCIENCE

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Prenatal Alcohol Exposure Increases Vulnerability to Stress and Anxiety-Like Disorders in Adulthood

(2009) Kim G.C. Hellemans et al.   Annals of the New York Academy of Sciences

Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice

(2009) Judit España et al.   BIOLOGICAL PSYCHIATRY

Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring

(2008) Xing-Hai Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY