Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 10, Issue 38, Pages 12730-12737Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.2c03605
Keywords
gold; nanoclusters; ligand; NIR; therapeutic; anticancer; kidneys; ROS
Categories
Funding
- SERB-DST
- INST
- UGC
- CSIR
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In this study, near-infrared-emitting Au-14 nanoclusters were synthesized using d-penicillamine as a surface stabilizing agent. The morphology and composition of the nanoclusters were characterized using electron microscopy and mass spectrometry. The nanoclusters exhibited molecule-like features and specifically inhibited cancer cells through preferential uptake, leading to intracellular ROS production.
Subnanometer-sized metal nanoclusters (NCs) with diameters <2 nm have emerged as promising materials in biomedical applications. Here, we report the synthesis of near-infrared (NIR)-emitting Au-14 nanoclusters using a small therapeutic molecule, d-penicillamine (DPA), as a surface stabilizing agent. We have characterized the morphology and composition of as-synthesized NCs using electron microscopy and mass spectrometry techniques. The photophysics of the NCs was investigated by UV-vis and photoluminescence (PL) spectroscopy. We found molecule-like features with three distinctive absorption bands at 390, 456, and 590 nm and a photoemission band at 696 nm. We observed that Au NCs specifically inhibited cancer cells dose-dependently through preferential uptake and imparted significant intracellular ROS. They did not show any acute toxicity in C57BL/6 mice at a dosage of 10 mg/kg, with predominant accumulation in the kidneys at the end of 24 h.
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