From Immunotoxins to Suicide Toxin Delivery Approaches: Is There a Clinical Opportunity?

Suicide gene therapy is a relatively novel form of cancer therapy in which a gene coding for enzymes or protein toxins is delivered through targeting systems such as vesicles, nanoparticles, peptide or lipidic co-adjuvants. The use of toxin genes is particularly interesting since their catalytic activity can induce cell death, damaging in most cases the translation machinery (ribosomes or protein factors involved in protein synthesis) of quiescent or proliferating cells. Thus, toxin gene delivery appears to be a promising tool in fighting cancer. In this review we will give an overview, describing some of the bacterial and plant enzymes studied so far for their delivery and controlled expression in tumor models.

Automated summary

Suicide gene therapy is a promising approach in cancer treatment, in which genes coding for enzymes or protein toxins are delivered to cells to induce cell death. This review provides an overview of bacterial and plant enzymes studied for their delivery and controlled expression in tumor models.