Article
Biochemistry & Molecular Biology
Aatrayee Das, Sonia Kundu, Mradu Gupta, Arup Mukherjee
Summary: In this research, bio-safe films were successfully developed for disrupting Escherichia coli biofilms and killing planktonic cells. The films, made from kojic acid and guar gum propionate, showed excellent physical and tensile properties. The results showed that the films were highly effective in inhibiting E.coli biofilms and planktonic cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Xiufeng Gong, Jin Yao, Bin Yang, Jun Guo, Haoran Sun, Wanzhong Yin
Summary: This study focused on the basic research of flotation separation of dolomite from brucite using guar gum (GG) as a selective regulator. The flotation tests showed that the use of GG inhibited the floating of dolomite but did not affect the floatability of brucite. Contact-angle measurements and zeta-potential measurements confirmed the difference in floatability between dolomite and brucite after the action of GG. Infrared-spectrum analysis and X-ray photoelectron spectroscopy detection provided further evidence of the interaction between GG and the mineral surfaces.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Multidisciplinary Sciences
Anna Krone, Yan Fu, Simon Schreiber, Johanna Kotrba, Loisa Borde, Aileen Noetzold, Christoph Thurm, Jonas Negele, Tobias Franz, Sabine Stegemann-Koniszewski, Jens Schreiber, Christoph Garbers, Aniruddh Shukla, Robert Geffers, Burkhart Schraven, Dirk Reinhold, Anne Dudeck, Annegret Reinhold, Andreas J. Muller, Sascha Kahlfuss
Summary: Zinc aspartate (UNIZINK) negatively regulates gene networks and metabolism of CD4(+) T cells, leading to impaired function and viability. High doses of zinc prevent Th1 CNS autoimmunity and Th2 allergy.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Tae Woo Kim, Yujin Kim, Wonsik Jung, Dong Eon Kim, Hyeongseop Keum, Youngju Son, Sangyong Jon
Summary: BRNPs have shown potential in delaying disease onset, suppressing disease progression and severity, and reducing disease incidence rate in the EAE mouse model, without the need for systemic immunosuppression. Studies have found that BRNPs negatively regulate the differentiation of naive CD4(+) T cells into Th17 cells by scavenging reactive oxygen species.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Byunghyun Park, Yu Sun Jeong, Wonseok Hu, Mingyu Lee, Ji Cheol Kim, Geon Ho Bae, Yong-Soo Bae, Yoe-Sik Bae
Summary: Multiple sclerosis (MS) is a disease that damages the brain and spinal cord, leading to paralysis. Recent research has shown that B cells play a significant role in the pathogenesis of MS, as autoantibodies from B cells are closely related to central nervous system damage and prognosis. Regulating the activity of antibody secreting cells may be linked to the severity of MS symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Marielen de Souza, Venessa Eeckhaut, Evy Goossens, Richard Ducatelle, Filip Van Nieuwerburgh, Karl Poulsen, Ana Angelita Sampaio Baptista, Ana Paula Frederico Rodrigues Loureiro Bracarense, Filip Van Immerseel
Summary: Galactomannans in broiler feed can negatively impact zootechnical performance and gut microbiota composition. Mannanase supplementation can restore the gut microbiota and improve performance to normal levels.
Article
Immunology
Ling Xie, Jie Lv, Kaidireya Saimaier, Sanxing Han, Mengyao Han, Chun Wang, Guangyu Liu, Wei Zhuang, Xiangrui Jiang, Changsheng Du
Summary: TPN10518, an artemisinin derivative, protects against experimental autoimmune encephalomyelitis (EAE) by inhibiting the production of Th1 and Th17 cells through AP1 downregulation. This study suggests that TPN10518 could be a potential drug for the treatment of multiple sclerosis (MS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Qiang Yu, Honghu Tu, Xueyi Yin, Chang Peng, Chuanyun Dou, Wenhua Yang, Wenbiao Wu, Xiaotong Guan, Jia Li, Hexin Yan, Yi Zang, Haowen Jiang, Qiang Xia
Summary: This study demonstrates that targeting glutamine metabolism can inhibit the activation and differentiation of T cells in autoimmune hepatitis (AIH), providing a potential new treatment strategy for AIH and other T cell-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Majid Ghareghani, Zahra Farhadi, Serge Rivest, Kazem Zibara
Summary: Combination therapy of melatonin and DADA significantly reduced the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. The therapy improved immune response, promoted oligodendrocyte generation, and affected cerebral energy metabolism. This study highlights the importance of combined treatment for enhancing the efficiency of melatonin in remyelination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Goran Stegnjaic, Antonios D. Tsiailanis, Milica Lazarevic, Vasileios K. Gkalpinos, Neda Djedovic, Thomas Antoniou, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Dorde Miljkovic, Andreas G. Tzakos, Bojan Jevtic
Summary: Gallic acid, a phenolic acid found in various plants, nuts, and fruits, has anti-oxidative and anti-inflammatory properties. Its phenethyl ester, PEGA, reduces the release of inflammatory substances and ameliorates an animal model of central nervous system inflammatory disease.
Article
Multidisciplinary Sciences
Qing Zhang, Xiao Lei, Fang Wang, Xiaoning He, Lu Liu, Yuxia Hou, Yuan Liu, Fang Jin, Chider Chen, Bei Li
Summary: Immune system disorders, especially T cell disorders, are important therapeutic targets of mesenchymal stem cells (MSCs) in many autoimmune diseases (ADs). ERK1 plays a crucial role in regulating T cells in MSCs, and MSCs treated with LA can improve the efficacy of MSC-based treatments for ADs.
Article
Immunology
Ling Xie, Kaidireya Saimaier, Chun Wang, Jingshu Yang, Mengyao Han, Jie Lv, Wei Zhuang, Guangyu Liu, Changsheng Du
Summary: Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system mediated by immune cells. The study of MS has significance for other autoimmune diseases. Research shows that Methyl Acetate (MA) can reduce disease severity in Experimental Autoimmune Encephalomyelitis (EAE) by reducing inflammation and demyelination, and increasing Th1 cells in the periphery while inducing chemokines CXCR3 expression. Additionally, MA alleviates intestinal inflammation in EAE mice by enhancing IL-10 and inhibiting IL-6 secretion, suggesting therapeutic implications for autoimmune diseases like MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jie Lv, Mengyao Han, Guangyu Liu, Wei Zhuang, Chun Wang, Ling Xie, Kaidireya Saimaier, Sanxing Han, Changjie Shi, Qiuhong Hua, Ru Zhang, Changsheng Du
Summary: Apoptosis is important in maintaining the homeostasis of the body and immune system, but its dysfunction can lead to autoimmune diseases like multiple sclerosis (MS). An animal model, experimental autoimmune encephalomyelitis (EAE), is used to study MS. In this study, we found that carboplatin (CA), a platinum anti-tumor drug, reduced inflammation and demyelination in EAE mice. CA also decreased pathogenic T cell numbers and proportions in the spleen and lymph nodes of EAE mice. Additionally, CA induced apoptosis and inhibited T cell proliferation. These findings suggest that CA has potential as a novel drug for MS treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Chunlei Feng, Lingyun Li, Qing Li, Kirsten Switzer, Mingyao Liu, Shuhua Han, Biao Zheng
Summary: Research shows that omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (DHA), regulate the functional activities of dendritic cells (DCs) to enhance anti-inflammatory effects in autoimmune diseases. By modulating DCs, DHA reduces proinflammatory cytokine production and increases regulatory T-cell induction capability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Huiqing Hou, Yafei Sun, Jun Miao, Mengying Gao, Li Guo, Xiujuan Song
Summary: Ponesimod treatment improved EAE and reduced inflammatory infiltration, decreasing Th1 and Th17 cell numbers while increasing Treg cell numbers, and modulated the levels of related cytokines and signaling pathways.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Review
Clinical Neurology
Jessica R. Allanach, John W. Farrell, Miceline Mesidor, Soheila Karimi-Abdolrezaee
Summary: This study systematically reviewed recent advances in neuroprotective and regenerative therapies for MS, finding that small molecules and antibody therapies are the most common strategies for promoting remyelination. However, further research is needed to address current barriers in implementing experimental treatments in clinical settings.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Virology
Andrew J. Sharon, Heather A. Filyk, Nicolette M. Fonseca, Rachel L. Simister, Renata B. Filler, Wallace Yuen, Blair K. Hardman, Hannah G. Robinson, Jung Hee Seo, Joana Rocha-Pereira, Ian Welch, Johan Neyts, Craig B. Wilen, Sean A. Crowe, Lisa C. Osborne
Summary: The intestinal microbiota is a collection of bacteria, archaea, fungi, and viruses that colonize the mammalian gut. The coevolution of the host and microbiota has required the development of immunological tolerance. This study focuses on the host-directed mechanisms of viral regulation and demonstrates the central role of STAT1 in regulating viral replication and antiviral T cell responses.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Michelle Zuo, Naomi M. Fettig, Louis-Philippe Bernier, Elisabeth Possnecker, Shoshana Spring, Annie Pu, Xianjie Ma, Dennis Sw Lee, Lesley A. Ward, Anshu Sharma, Jens Kuhle, John G. Sled, Anne-Katrin Probstel, Brian A. MacVicar, Lisa C. Osborne, Jennifer L. Gommerman, Valeria Ramaglia
Summary: The progression and pathology of multiple sclerosis (MS) in patients are associated with age and other immune cells, such as neutrophils, in addition to the inflammation caused by autoreactive T cells.
Editorial Material
Immunology
Leah S. Hohman, Lisa C. Osborne
Summary: This article discusses the crucial role of eosinophils in maintaining intestinal homeostasis, including their importance in protective immunity and allergy.
Review
Cell Biology
Leah S. Hohman, Lisa C. Osborne
Summary: This review discusses emerging data on age-related loss of intestinal barrier integrity and suggests that IEC dysfunction may play a central role in age-associated alterations in microbiota composition and immune homeostasis.
Article
Multidisciplinary Sciences
Isobel C. Mouat, Jessica R. Allanach, Naomi M. Fettig, Vina Fan, Anna M. Girard, Iryna Shanina, Lisa C. Osborne, Galina Vorobeychik, Marc S. Horwitz
Summary: This study compares the phenotypic changes of age-associated B cells (ABCs) in viral infection and autoimmunity in humans and mice, and identifies ABCs as functional mediators of viral-enhanced autoimmunity.
Meeting Abstract
Immunology
Michelle Xiao Le Zuo, Naomi M. Fettig, Lisa C. Osborne, Jennifer L. Gommerman, Valeria Ramaglia
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Andrew J. Sharon, Heather A. Filyk, Nicolette M. Fonseca, Rachel L. Simister, Renata B. Filler, Wallace Yuen, Blair K. Hardman, Hannah G. Robinson, Jung Hee Seo, Joana Rocha-Pereira, Ian Welch, Johan Neyts, Craig B. Wilen, Sean A. Crowe, Lisa C. Osborne
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Naomi M. Fettig, Hannah G. Robinson, Jessica R. Allanach, Rachel L. Simister, Elsie J. Wang, Ye Jiayu, Katherine M. Davis, Jung Hee Seo, Deanna L. Gibson, Sean A. Crowe, Marc S. Horwitz, Lisa C. Osborne
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Blair K. Hardman, Lisa C. Osborne
JOURNAL OF IMMUNOLOGY
(2022)