Journal
STEM CELL RESEARCH & THERAPY
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13287-022-03111-8
Keywords
Lipid raft; Cancer; Cancer stem cell; Self-renewal; Drug resistance; Epithelial-mesenchymal transition; Cancer stem cell niche
Funding
- National Natural Sciences Foundation of China [81973668, 81774130]
- Key Project of the Educational Department of Hunan Province [20A375]
- Pharmaceutical Open Fund of Domestic First-class Disciplines (cultivation) of Hunan Province [2021YX07]
- Scientific Research Project of Changsha Science and Technology Bureau [kq2004060]
- Key Project of Hunan Provincial Health Commission [202213055529]
- Natural Science Foundation of Hunan Province [2022JJ80088]
- Graduate Research innovation project of Hunan University of Chinese Medicine [2021CX48, 2021CX08]
- First-Class Discipline of Pharmaceutical Science of Hunan
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Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties, and lipid rafts play a crucial role in CSCs, making them promising therapeutic targets for cancer treatment.
Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in the plasma membrane that mediate various intracellular signaling. The occurrence and progression of cancer are closely related to lipid rafts. Emerging evidence indicates that lipid raft levels are significantly enriched in CSCs compared to cancer cells and that most CSC markers such as CD24, CD44, and CD133 are located in lipid rafts. Furthermore, lipid rafts play an essential role in CSCs, specifically in CSC self-renewal, epithelial-mesenchymal transition, drug resistance, and CSC niche. Therefore, lipid rafts are critical regulatory platforms for CSCs and promising therapeutic targets for cancer therapy.
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