Blood–brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication

Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia

(2021) Carmen Gasca-Salas et al.   Nature Communications

Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

(2021) Ko-Ting Chen et al.   Science Advances

Quantitative analysis of in-vivo microbubble distribution in the human brain

(2021) Francesco Prada et al.   Scientific Reports

Safety and feasibility of multiple blood-brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy

(2020) So Hee Park et al.   JOURNAL OF NEUROSURGERY

Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model

(2020) Christopher Pham Pacia et al.   Scientific Reports

A new safety index based on intrapulse monitoring of ultra-harmonic cavitation during ultrasound-induced blood-brain barrier opening procedures

(2020) A. Novell et al.   Scientific Reports

β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease

(2020) Pierre-François D’Haese et al.   Frontiers in Human Neuroscience

One-Year Outcome of Multiple Blood–Brain Barrier Disruptions With Temozolomide for the Treatment of Glioblastoma

(2020) So Hee Park et al.   Frontiers in Oncology

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

(2019) Todd Mainprize et al.   Scientific Reports

Method to optimize the placement of a single-element transducer for transcranial focused ultrasound

(2019) Tae Young Park et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Correlation Between Brain Tissue Damage and Inertial Cavitation Dose Quantified Using Passive Cavitation Imaging

(2019) Shanshan Xu et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

(2019) Agessandro Abrahao et al.   Nature Communications

Feedback control of microbubble cavitation for ultrasound-mediated blood–brain barrier disruption in non-human primates under magnetic resonance guidance

(2018) Hermes AS Kamimura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons

(2018) Dezhuang Ye et al.   JOURNAL OF CONTROLLED RELEASE

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening

(2018) Ryan M. Jones et al.   Theranostics

State-of-the-art of microbubble-assisted blood-brain barrier disruption

(2018) Kang-Ho Song et al.   Theranostics

Closed-loop cavitation control for focused ultrasound-mediated blood-brain-barrier opening by long-circulating microbubbles

(2018) Mustafa Cavusoglu et al.   PHYSICS IN MEDICINE AND BIOLOGY

Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model

(2017) Tao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opening the Blood-Brain Barrier with MR Imaging–guided Focused Ultrasound: Preclinical Testing on a Trans–Human Skull Porcine Model

(2017) Yuexi Huang et al.   RADIOLOGY

Cavitation-enhanced nonthermal ablation in deep brain targets: feasibility in a large animal model

(2016) Costas D. Arvanitis et al.   JOURNAL OF NEUROSURGERY

Transcranial cavitation detection in primates during blood-brain barrier opening-a performance assessment study

(2014) Shih-Ying Wu et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

(2014) Hong Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery

(2014) Ching-Hsiang Fan et al.   PLoS One

Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound

(2013) Alison Burgess et al.   ACS Chemical Neuroscience

Temporary Disruption of the Blood-Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

(2012) N. McDannold et al.   CANCER RESEARCH

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions–based Controller

(2012) Meaghan A. O’Reilly et al.   RADIOLOGY

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

(2012) Lisa H. Treat et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

(2011) Chien-Yu Ting et al.   BIOMATERIALS

Attenuation, scattering, and absorption of ultrasound in the skull bone

(2011) Gianmarco Pinton et al.   MEDICAL PHYSICS

Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo

(2011) Fabrice Marquet et al.   PLoS One

In vivotranscranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice

(2010) Yao-Sheng Tung et al.   PHYSICS IN MEDICINE AND BIOLOGY

The pig model in brain imaging and neurosurgery

(2009) P. Sauleau et al.   Animal

Effects of Transcranial Ultrasound and Intravenous Microbubbles on Blood Brain Barrier Permeability in a Large Animal Model

(2008) Feng Xie et al.   ULTRASOUND IN MEDICINE AND BIOLOGY