Polygenic Health Index, General Health, and Pleiotropy: Sibling Analysis and Disease Risk Reduction

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

(2022) Florian Privé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

(2022) Omer Weissbrod et al.   NATURE GENETICS

Population-specific causal disease effect sizes in functionally important regions impacted by selection

(2021) Huwenbo Shi et al.   Nature Communications

The Impact of Disease Comorbidities in Alzheimer's Disease

(2021) Jose A. Santiago et al.   Frontiers in Aging Neuroscience

Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues

(2021) Anna C. F. Lewis et al.   Genome Medicine

Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank

(2021) Erik Widen et al.   Genes

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

(2021) Francesca Forzano et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality

(2020) Allison Meisner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic architecture of complex traits and disease risk predictors

(2020) Soke Yuen Yong et al.   Scientific Reports

Evaluating co‐created patient‐facing materials to increase understanding of genetic test results

(2020) Andrew A. Dwyer et al.   Journal of Genetic Counseling

From Basic Science to Clinical Application of Polygenic Risk Scores

(2020) Naomi R. Wray et al.   JAMA Psychiatry

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Comorbidity in patients with cardiovascular disease in primary care: a cohort study with routine healthcare data

(2019) Josefien Buddeke et al.   BRITISH JOURNAL OF GENERAL PRACTICE

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

(2019) Tom G Richardson et al.   eLife

A comparison of genomic laboratory reports and observations that may enhance their clinical utility for providers and patients

(2019) Kyle Walter Davis et al.   Molecular Genetics & Genomic Medicine

Mind the gap: resources required to receive, process and interpret research-returned whole genome data

(2019) Dana C. Crawford et al.   HUMAN GENETICS

Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women

(2019) Heidi D. Nelson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predicting Cardiovascular Disease Among Testicular Cancer Survivors After Modern Cisplatin-based Chemotherapy: Application of the Framingham Risk Score

(2018) Darren R. Feldman et al.   Clinical Genitourinary Cancer

Direct-to-consumer raw genetic data and third-party interpretation services: more burden than bargain?

(2018) Tia Moscarello et al.   GENETICS IN MEDICINE

Medical Comorbidity in Alzheimer’s Disease: A Nested Case-Control Study

(2018) Jen-Hung Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Clinical and Genetic Risk Factors for Adverse Metabolic Outcomes in North American Testicular Cancer Survivors

(2018) Mohammad Abu Zaid et al.   Journal of the National Comprehensive Cancer Network

Genome-wide polygenic risk predictors for kidney disease

(2018) Lili Liu et al.   Nature Reviews Nephrology

Chronic comorbidities associated with inflammatory bowel disease

(2017) Caroline Bähler et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Breast cancer risk prediction using a clinical risk model and polygenic risk score

(2016) Yiwey Shieh et al.   BREAST CANCER RESEARCH AND TREATMENT

Recommendations for the integration of genomics into clinical practice

(2016) Sarah Bowdin et al.   GENETICS IN MEDICINE

Developing and evaluating polygenic risk prediction models for stratified disease prevention

(2016) Nilanjan Chatterjee et al.   NATURE REVIEWS GENETICS

Multiple Comorbidities of 21 Psychological Disorders and Relationships With Psychosocial Variables: A Study of the Online Assessment and Diagnostic System Within a Web-Based Population

(2015) Ali M AL-Asadi et al.   JOURNAL OF MEDICAL INTERNET RESEARCH

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Genomics in clinical practice

(2014) James R Priest et al.   HEART

Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning

(2014) Gad Abraham et al.   PLoS Genetics

Public Knowledge of and Attitudes Toward Genetics and Genetic Testing

(2013) Susanne B. Haga et al.   Genetic Testing and Molecular Biomarkers

What does it mean to be genomically literate?: National Human Genome Research Institute Meeting Report

(2013) Belen Hurle et al.   GENETICS IN MEDICINE

Genetic Literacy and Competency

(2013) C. Kaye et al.   PEDIATRICS

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Comorbidities of Diabetes and Hypertension: Mechanisms and Approach to Target Organ Protection

(2011) Amanda N. Long et al.   Journal of Clinical Hypertension

A formal risk-benefit framework for genomic tests: Facilitating the appropriate translation of genomics into clinical practice

(2010) David L Veenstra et al.   GENETICS IN MEDICINE

Assessing Women at High Risk of Breast Cancer: A Review of Risk Assessment Models

(2010) E. Amir et al.   JNCI-Journal of the National Cancer Institute

Communicating Genetic and Genomic Information: Health Literacy and Numeracy Considerations

(2010) D.H. Lea et al.   Public Health Genomics

The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling

(2010) Naomi R. Wray et al.   PLoS Genetics

Clinical geneticists’ and genetic counselors’ views on the communication of genetic risks: A qualitative study

(2008) Lidewij Henneman et al.   PATIENT EDUCATION AND COUNSELING

Psychiatric Comorbidities and Schizophrenia

(2008) P. F. Buckley et al.   SCHIZOPHRENIA BULLETIN