Natural Products for Liver Cancer Treatment: From Traditional Medicine to Modern Drug Discovery

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells

(2021) Yulai You et al.   BIOMEDICINE & PHARMACOTHERAPY

Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression

(2021) Danhui Ma et al.   Frontiers in Oncology

Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT/CyclinD1/p21/p27 pathway

(2021) Xue Yang et al.   PHYTOMEDICINE

Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics

(2021) Xing-Ran Zhai et al.   Frontiers in Pharmacology

Treatment for liver cancer: From sorafenib to natural products

(2021) Shuli Man et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nutraceuticals and Cancer: Potential for Natural Polyphenols

(2021) Jessica Maiuolo et al.   Nutrients

The Antitumor Effects of Britanin on Hepatocellular Carcinoma Cells and its Real-time Evaluation by In Vivo Bioluminescence Imaging

(2020) Hanrui Li et al.   Anti-Cancer Agents in Medicinal Chemistry

Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction of CD59 expression and phospholipase D activity

(2020) Mahmoud Abdel‐Latif et al.   CELL BIOCHEMISTRY AND FUNCTION

Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats

(2020) Nariman K. Badr El-Din et al.   BIOMEDICINE & PHARMACOTHERAPY

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma

(2020) Yi Xiao et al.   Cancer Cell International

“Natural” is not synonymous with “Safe”: Toxicity of natural products alone and in combination with pharmaceutical agents

(2020) Tyler E. Gaston et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Pilot study of the combination of sorafenib and fractionated irinotecan in pediatric relapse/refractory hepatic cancer (FINEX pilot study)

(2020) Dai Keino et al.   PEDIATRIC BLOOD & CANCER

Synergistic anti-liver cancer effects of curcumin and total ginsenosides

(2020) Zhe Deng et al.   World Journal of Gastrointestinal Oncology

A Phase II Clinical Trial on the Combination Therapy of PHY906 Plus Capecitabine in Hepatocellular Carcinoma

(2020) Chun A. Changou et al.   ONCOLOGIST

Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance

(2020) Chunlei Wang et al.   MEDICAL SCIENCE MONITOR

Systematic Review of Published Data on Herb Induced Liver Injury

(2019) Jung-Hwan Byeon et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice

(2019) Hong-wei Chen et al.   Chinese Journal of Integrative Medicine

Biochemical and morphological changes in mouse liver induced by mistletoe toxins

(2019) Anna Wieczorek et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective Effects of Defatted Sticky Rice Bran Extracts on the Early Stages of Hepatocarcinogenesis in Rats

(2019) Aphisit Dokkaew et al.   MOLECULES

Natural products in licorice for the therapy of liver diseases: Progress and future opportunities

(2019) Xiaojiaoyang Li et al.   PHARMACOLOGICAL RESEARCH

Jiedu Granule Combined with Transcatheter Arterial Chemoembolization and Gamma Knife Radiosurgery in Treating Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

(2019) Jianchu Wang et al.   Biomed Research International

Atractylon induces apoptosis and suppresses metastasis in hepatic cancer cells and inhibits growth in vivo

(2019) Yang Cheng et al.   Cancer Management and Research

Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways

(2019) Gaurab Roy et al.   Frontiers in Oncology

Research progress on the anti-hepatic fibrosis action and mechanism of natural products

(2019) Liang Shan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study

(2019) Shuaibing He et al.   Biomolecules

Challenges in liver cancer and possible treatment approaches

(2019) David Anwanwan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Traditional herbal medicine prevents postoperative recurrence of small hepatocellular carcinoma: A randomized controlled study

(2018) Xiao-feng Zhai et al.   CANCER

The protective mechanism of Nigella sativa against diethylnitrosamine-induced hepatocellular carcinoma through its antioxidant effect and EGFR/ERK1/2 signaling

(2018) Y. R. Shahin et al.   ENVIRONMENTAL TOXICOLOGY

Evidences for the antitumor potentiality of Hemimycale arabica and Negombata magnifica mesohyls in hepatocellular carcinoma rat model

(2018) Hanaa H. Ahmed et al.   MEDICINAL CHEMISTRY RESEARCH

Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

(2018) Fang Shi et al.   MedChemComm

The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death

(2018) Ge Liu et al.   Cell Death & Disease

Dietary Tomato Powder Inhibits High-Fat Diet–Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes

(2018) Hui Xia et al.   Cancer Prevention Research

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

(2017) Weijun Ou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma

(2017) Tianshu Liu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy

(2017) Wen Yee Chay et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Transarterial chemoembolization combined with Huaier granule for the treatment of primary hepatic carcinoma

(2017) Guang Sheng Zhao et al.   MEDICINE

Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis

(2017) Velayutham Sadeeshkumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis

(2017) Nissar Ahmad Wani et al.   MOLECULAR CANCER RESEARCH

Anti‑tumour effects of polysaccharide extracted from Acanthopanax�senticosus and cell‑mediated immunity

(2017) Qinglong Meng et al.   Experimental and Therapeutic Medicine

A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer

(2017) Wenbo Yao et al.   EBioMedicine

Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats

(2017) Gokuladhas Krishnan et al.   Asian Journal of Pharmaceutical Sciences

Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins

(2016) Peiyu Qiu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals

(2016) Jong Doo Lee et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats

(2016) Xiaodong Wen et al.   GASTROENTEROLOGY

Jian Pi Li Qi Decoction Alleviated Postembolization Syndrome Following Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

(2016) Litao Xu et al.   INTEGRATIVE CANCER THERAPIES

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain

(2016) Xiaowei Ye et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation

(2016) Bin Xiao et al.   MOLECULES

Neem tree (Azadirachta indica) extract specifically suppresses the growth of tumors in H22-bearing Kunming mice

(2016) Zhenxiang He et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo

(2016) Jingjing Song et al.   Oncotarget

Discovery and resupply of pharmacologically active plant-derived natural products: A review

(2015) Atanas G. Atanasov et al.   BIOTECHNOLOGY ADVANCES

Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan

(2015) Xihua Yang et al.   INTEGRATIVE CANCER THERAPIES

Treatment of Liver Cancer

(2015) Chun-Yu Liu et al.   Cold Spring Harbor Perspectives in Medicine

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Antiangiogenic phytochemicals and medicinal herbs

(2010) Soo-Jin Jeong et al.   PHYTOTHERAPY RESEARCH