Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

Long‐term corticosteroid use, adrenal insufficiency, and the need for steroid‐sparing treatment in adult severe asthma

(2021) Mark Gurnell et al.   JOURNAL OF INTERNAL MEDICINE

Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial

(2021) Irene E. Braithwaite et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The safety of JAK-1 inhibitors

(2021) Benjamin Clarke et al.   RHEUMATOLOGY

Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses

(2021) Daniel Schnepf et al.   Science Immunology

Surfactant protein A modulates the activities of the JAK/STAT pathway in suppressing Th1 and Th17 polarization in murine OVA-induced allergic asthma

(2021) Xi Chen et al.   LABORATORY INVESTIGATION

JAK inhibitors for asthma

(2021) Steve N. Georas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379

(2021) Andreas Stumpf et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

TD-8236, a lung-selective inhaled pan-JAK inhibitor, inhibits gene expression related to severe asthma and exhaled nitric oxide (FeNO), in 3-D airway epithelium liquid interface (ALI) cultures derived from asthmatic donors

(2020) Elad Kaufman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

How can we minimise the use of regular oral corticosteroids in asthma?

(2020) Arnaud Bourdin et al.   European Respiratory Review

Prediction of response to biological treatment with monoclonal antibodies in severe asthma

(2020) J.A. Kroes et al.   BIOCHEMICAL PHARMACOLOGY

Treatment options in type-2 low asthma

(2020) Timothy SC Hinks et al.   EUROPEAN RESPIRATORY JOURNAL

Selective JAKinibs: Prospects in Inflammatory and Autoimmune Diseases

(2019) Anniina T. Virtanen et al.   BIODRUGS

Novel inhaled pan-JAK inhibitor, LAS194046, reduces allergen-induced airway inflammation, late asthmatic response and pSTATs activation in Brown Norway rats.

(2019) Marta Calbet et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanisms and therapeutic strategies for Non‐T2 Asthma

(2019) Eric Sze et al.   ALLERGY

Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma

(2019) Mark Zak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

(2018) Elin Boger et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

(2018) Massimo Gadina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies

(2018) J Mark FitzGerald et al.   Lancet Respiratory Medicine

Systematic literature review of the clinical, humanistic, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment

(2018) Stephanie Chen et al.   CURRENT MEDICAL RESEARCH AND OPINION

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

(2018) Hart S. Dengler et al.   Science Translational Medicine

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

(2017) Diane Lefaudeux et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma

(2016) Brian D. Hondowicz et al.   IMMUNITY

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Th9 and other IL-9-producing cells in allergic asthma

(2016) Sonja Koch et al.   Seminars in Immunopathology

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Asthma

(2015) Stephen T. Holgate et al.   Nature Reviews Disease Primers

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling

(2014) J. Zhong et al.   Database-The Journal of Biological Databases and Curation

Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses

(2013) Shigeru Ashino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Optimisation of DMPK by the Inhaled Route: Challenges and Approaches

(2012) Anne E. Cooper et al.   CURRENT DRUG METABOLISM

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Postnatal growth of tracheobronchial airways of Sprague-Dawley rats

(2011) DongYoub Lee et al.   JOURNAL OF ANATOMY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

A role for sensory nerves in the late asthmatic response

(2011) Kristof Raemdonck et al.   THORAX

Distinct Signal Codes Generate Dendritic Cell Functional Plasticity

(2010) K. Arima et al.   Science Signaling

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

(2008) Elizabeth Kudlacz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY