Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Lucia Baratto, Negin Hatami, Tie Liang, Craig S. Levin, Mohammad Mehdi Khalighi, Andrei Iagaru
Summary: The study evaluates the effect of different reduced PET acquisition times in patients with prostate cancer who underwent Ga-68-PSMA-11 or (68)GaRM2 PET/MRI. Results suggest that routine 3-minute acquisitions provide similar results to 4-minute acquisitions, while 2-minute acquisitions provide acceptable performance.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yining Wang, Zijun Chen, Yinjie Zhu, Haitao Zhao, Lianghua Li, Gang Huang, Wei Xue, Ruohua Chen, Jianjun Liu
Summary: The purpose of this study was to assess whether total-body [(68) Ga]Ga-PSMA-11 PET/CT could improve the detection rate compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer. The results showed that total-body [(68) Ga]Ga-PSMA-11 PET/CT had better objective evaluation in terms of background noise, lesion prominence, liver SD, SNR, and lesion SUVmax compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT. Overall, total-body [(68) Ga]Ga-PSMA-11 PET/CT had a significantly higher detection rate for biochemical recurrent prostate cancer compared to conventional [(68) Ga]Ga-PSMA-11 PET/CT. Rating: 9/10.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaomei Gao, Yongxiang Tang, Minfeng Chen, Jian Li, Hongling Yin, Yu Gan, Xiongbin Zu, Yi Cai, Shuo Hu
Summary: This study compared [Ga-68]Ga-RM26 PET/CT and [Ga-68]Ga-PSMA-617 PET/CT for diagnosing prostate cancer, and found that [Ga-68]Ga-PSMA-617 PET/CT had superior accuracy in detecting clinically significant PCa, while [Ga-68]Ga-RM26 PET/CT showed an advantage for imaging low-risk PCa.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biotechnology & Applied Microbiology
Samuele Ghezzo, Ilaria Neri, Paola Mapelli, Annarita Savi, Ana Maria Samanes Gajate, Giorgio Brembilla, Carolina Bezzi, Beatrice Maghini, Tommaso Villa, Alberto Briganti, Francesco Montorsi, Francesco De Cobelli, Massimo Freschi, Arturo Chiti, Maria Picchio, Paola Scifo
Summary: This study proposes a new workflow for accurate co-registration of prostate PET images with histopathological images using a dual-tracer PET/MRI study. The method allows a deeper understanding of PET tracer distribution and enables advanced analyses. The co-registration workflow involves five steps and the precision was evaluated using target registration error (TRE) and DICE score.
BIOENGINEERING-BASEL
(2023)
Review
Oncology
Ruizhe Huang, Yizhen Li, Haowen Wu, Boyi Liu, Xuanjun Zhang, Zhongxi Zhang
Summary: The aim of this study was to compare the diagnostic efficacy of Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI in patients with biochemically recurrent prostate cancer. A meta-analysis and systematic review were conducted, analyzing 37 studies involving 8409 patients. The results showed that Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI had similar detection rates for biochemically recurrent prostate cancer. However, larger prospective studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuheng Liu, Lianghua Li, Yanyu Qin, Zijun Chen, Haitao Zhao, Xinlu Wang, Ruohua Chen
Summary: The objective of this study was to compare the diagnostic performance and image quality of total-body PET/CT imaging using half-dose of [(68) Ga]Ga-PSMA radiotracer to conventional PET/CT imaging using full dose of [(68) Ga]Ga-PSMA. The results showed that total-body PET/CT with half-dose of [(68) Ga]Ga-PSMA yielded comparable image quality and diagnostic performance to conventional PET/CT, while reducing radiation exposure for the subjects.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wojciech Cytawa, Stefan Kircher, Hubert Kuebler, Rudolf A. Werner, Simon Weber, Philipp Hartrampf, Tomasz Bandurski, Piotr Lass, Wojciech Polom, Marcin Matuszewski, Hans-Juergen Wester, Constantin Lapa, Andreas Rosenwald, Anna Katharina Seitz, Andreas K. Buck
Summary: The purpose of this study was to validate the expression of primary tumor PSMA in prostate cancer patients using [Ga-68]Ga-PSMA PET/CT imaging. The results showed that among PSMA-positive patients, about one-third had lymph node metastases, which were associated with PSMA expression and tumor volume. In contrast, only 1 out of 7 PET-negative patients had lymph node involvement. These results suggest that PSMA-positive prostate cancer may have a higher risk of aggressiveness and distant metastasis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
David A. Pattison, Maciej Debowski, Brook Gulhane, Evyn G. Arnfield, Anita M. Pelecanos, Peter L. Garcia, Melissa J. Latter, Charles Y. Lin, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas
Summary: This study aimed to compare the concordance of [F-18]PSMA-1007 and [(68)Ga]Ga-PSMA-11 in TNM diagnosis and tracer uptake. The results showed differences in tracer uptake in most physiological sites, but high consistency in overall AJCC prognostic stage.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guochang Wang, Linlin Li, Jie Zang, Haiyan Hong, Lin Zhu, Hank F. Kung, Zhaohui Zhu
Summary: This study compared the diagnostic performance of Ga-68-P16-093 and Ga-68-PSMA-617 PET/CT in primary prostate cancer patients. The results showed that Ga-68-P16-093 PET/CT detected more positive tumors and had higher tumor uptake and better tumor detection capability than Ga-68-PSMA-617 PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Yee Ling Ng, Xinlan Yang, Yinjie Zhu, Lianghua Li, Haitao Zhao, Yun Zhou, Gang Huang, Jianjun Liu
Summary: Total-body parametric imaging of [(68) Ga]Ga-PSMA-11 improved lesion contrast and detectability compared to SUV images, which may serve as an imaging biomarker and theranostic tool for precise diagnosis and treatment evaluation in prostate cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Wenxiao Yu, Ming Zhao, Yingjun Deng, Shengjing Liu, Guanchao Du, Bin Yan, Ziwei Zhao, Ning Sun, Jun Guo
Summary: This study compared the diagnostic value of (18) F-PSMA-1007 PET/CT, (18) F-FDG PET/CT, and Ga-68-PSMA PET/CT in prostate cancer. The results showed that both (18) F-PSMA-1007 PET/CT and Ga-68 PSMA PET/CT demonstrated higher diagnostic efficacy compared to (18) F-FDG PET/CT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhilong Yi, Siqi Hu, Xiaofeng Lin, Qiong Zou, MinHong Zou, Zhanlei Zhang, Lei Xu, Ningyi Jiang, Yong Zhang
Summary: The study investigated the use of machine learning-based radiomics models derived from (68) Ga-PSMA PET images to predict invisible intraprostatic lesions. Results showed that these models could accurately predict such lesions and outperformed PSA density in diagnostic performance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaan Akcay, Ali Kibar, Onur Erdem Sahin, Muhammet Demirbilek, Gamze Beydagi, Sertac Asa, Fuad Aghazada, Turkay Toklu, Nalan Alan Selcuk, Bulent Onal, Levent Kabasakal
Summary: The study retrospectively reviewed 147 patient records and found that [(68) Ga]Ga-PSMA-11 PET/CT imaging has potential value in diagnosing clinically significant prostate cancer. PRIMARY scoring was more reliable than PIRADS scoring in diagnosing significant prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Fuquan Deng, Xiaoyuan Li, Fengjiao Yang, Hongwei Sun, Jianmin Yuan, Qiang He, Weifeng Xu, Yongfeng Yang, Dong Liang, Xin Liu, Greta S. P. Mok, Hairong Zheng, Zhanli Hu
Summary: This study used deep learning methods to perform low-dose image restoration on PSMA PET/MRI and found that synthesizing full-dose PET images based on MRI priors using 50% dose PET images did not affect the clinical diagnosis of prostate cancer. Prostate cancer patients can undergo 68Ga-PSMA prostate PET/MRI scans with radiation doses reduced by up to 50% through the use of deep learning methods to synthesize FDPET images.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moon Kim, Robert Seifert, Jana Fragemann, David Kersting, Jacob Murray, Frederic Jonske, Kelsey L. Pomykala, Jan Egger, Wolfgang P. Fendler, Ken Herrmann, Jens Kleesiek
Summary: The aim of this study was to evaluate the effect of thresholding algorithms on the quantification of PSMA-TV in advanced prostate cancer patients and validate its prognostic value. A total of 78 patients who underwent radionuclide therapy were included in the study. Different thresholding methods showed a high positive correlation with the baseline method for quantifying PSMA-TV.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Akira Toriihara, Tomomi Nobashi, Lucia Baratto, Heying Duan, Farshad Moradi, Sonya Park, Negin Hatami, Carina Mari Aparici, Guido Davidzon, Andrei Iagaru
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Baratto, Heying Duan, Helmut Maecke, Andrei Iagaru
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Baratto, Heying Duan, Valentina Ferri, Mehdi Khalighi, Andrei Iagaru
CLINICAL NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Mohamed H. Khalaf, Valentina Ferri, Lucia Baratto, Shyam M. Srinivas, Daniel Y. Sze, Andrei Iagaru
Summary: Tc-99m-MAA SPECT/CT showed great accuracy for treatment planning dosimetry. The SiPM-based PET/CT scanner demonstrated good image quality at a 10-min scan time in one bed position. A 5-min PET/CT scan time revealed acceptable image quality, which is sufficient for dosimetry and treatment verification.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
H. Duan, L. Baratto, R. Laudicella, F. Stracuzzi, S. Baldari, A. Iagaru
Summary: PDAC and pNETs are two major types of pancreatic tumors, with imaging playing a crucial role in diagnosis and treatment. FDG PET/CT shows high sensitivity and specificity in PDAC evaluation, while PET/CT and PET/MRI combining functional and structural data may provide a more accurate assessment of disease spread.
CLINICAL AND TRANSLATIONAL IMAGING
(2021)
Article
Oncology
Ryusuke Nakamoto, Jialin Zhuo, Kip E. Guja, Heying Duan, Stephanie L. Perkins, Christoph Leuze, Bruce L. Daniel, Benjamin Lewis Franc
Summary: This study demonstrates the accurate localization of targets in the head and neck region using 3D augmented reality (AR) visualization of single-photon emission computed tomography (SPECT)/computed tomography (CT) data. The results show that wearing an AR headset significantly reduces the time required for target detection and provides high localization accuracy.
Article
Oncology
Heying Duan, Valentina Ferri, George Albert Fisher, Shagufta Shaheen, Guido Alejandro Davidzon, Andrei Iagaru, Carina Mari Aparici
Summary: This study investigated the hepatic and renal toxicity of PRRT treatment in 86 patients. The results showed that PRRT treatment did not have a negative impact on liver and renal function, even in patients with pre-existing impaired parameters. Only transient grade 2 hypoalbuminemia and nephrotoxicity were observed during PRRT treatment.
Article
Oncology
Yu-Jin Lee, Nynke S. van den Berg, Heying Duan, E. Carmen Azevedo, Valentina Ferri, Marisa Hom, Roan C. Raymundo, Alex Valencia, Jessa Castillo, Bin Shen, Quan Zhou, Laura Freeman, Mary Ellen Koran, Michael J. Kaplan, A. Dimitrios Colevas, Fred M. Baik, Frederick T. Chin, Brock A. Martin, Andrei Iagaru, Eben L. Rosenthal
Summary: This study aimed to evaluate the safety and specificity of a tumor-targeted radiotracer in combination with PET/CT for improving the diagnostic accuracy of head and neck squamous cell carcinoma. The results showed that the combined use of two imaging techniques significantly improved the ability to detect HNSCC with higher specificity.
CLINICAL CANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Andrei Iagaru
Summary: Molecular imaging plays a crucial role in precision medicine, helping us understand tumor biology and select appropriate treatments. Studies have shown heterogeneity in receptor expression in primary and metastatic prostate cancer, and more prospective trials are needed to explore the relationship between receptor expression and tumor biology in different stages and types of prostate cancer. Additionally, the impact of standard treatments on receptor expression should be investigated.
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Andrei Iagaru
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Guido A. A. Davidzon, Farshad Moradi, Tie Liang, Hong Song, Andrei Iagaru
Summary: This study proposes a modification of the PROMISE criteria for GRPR-targeted PET. The mPROMISE criteria show reliability and high interrater agreement across all major categories. This modification will aid clinicians in decreasing uncertainty and achieving uniform evaluation, reporting, and comparability of GRPR-targeted PET.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Meeting Abstract
Oncology
Lucia Baratto, Hong Song, Heying Duan, Carina Mari Aparici, Guido Davidzon, Farshad Moradi, Sandy Srinivas, Andrei Iagaru
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Hong Song, Heying Duan, Caitlyn Harrison, Kip Guja, Negin Hatami, Benjamin Lewis Franc, Farshad Moradi, Carina Mari Aparici, Guido Davidzon, Sandy Srinivas, Andrei Iagaru
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Heying Duan, Gaia Ninatti, Bradley Girod, Valentina Ferri, Pamela L. Kunz, George A. Fisher, Farshad Moradi, Guido Alejandro Davidzon, Benjamin Lewis Franc, Andrei Iagaru, Carina Mari
JOURNAL OF CLINICAL ONCOLOGY
(2020)