Article
Medicine, General & Internal
Noha Yahia Ebaid, Dalia Nabil Khalifa, Ahmad Sabry Ragheb, Magdy Mohamad Abdelsamie, Ahmed Mohamed Alsowey
Summary: The study confirmed that CAD-RADS is a standard tool with high diagnostic accuracy and practicality in clinical practice. Additionally, a significant relationship between coronary calcium grading and severe CAD was detected.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Urology & Nephrology
Rudolf A. Werner, Philipp E. Hartrampf, Wolfgang P. Fendler, Sebastian E. Serfling, Thorsten Derlin, Takahiro Higuchi, Kenneth J. Pienta, Andrei Gafita, Thomas A. Hope, Martin G. Pomper, Matthias Eiber, Michael A. Gorin, Steven P. Rowe
Summary: PSMA-RADS is a standardized reporting and data system for classifying prostate cancer lesions. Studies have shown that the different categories of PSMA-RADS reflect their actual meanings, and there is high concordance among observers. This system can also assist in clinical decision-making, such as avoiding overtreatment in oligometastatic disease. However, there are also limitations to PSMA-RADS, which need to be updated to optimize lesion-level characterization.
Article
Cardiac & Cardiovascular Systems
Ricardo C. Cury, Jonathon Leipsic, Suhny Abbara, Stephan Achenbach, Daniel Berman, Marcio Bittencourt, Matthew Budoff, Kavitha Chinnaiyan, Andrew D. Choi, Brian Ghoshhajra, Jill Jacobs, Lynne Koweek, John Lesser, Christopher Maroules, Geoffrey D. Rubin, Frank J. Rybicki, Leslee J. Shaw, Michelle C. Williams, Eric Williamson, Charles S. White, Todd C. Villines, Ron Blankstein
Summary: Coronary Artery Disease Reporting and Data System (CAD-RADS) is a standardized reporting system for patients undergoing coronary CT angiography (CCTA), aiming to guide patient management. The updated CAD-RADS 2.0 improves the initial reporting system for CCTA by considering new technical developments and clinical guidelines, including the assessment of stenosis, plaque burden, and modifiers.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ricardo C. Cury, Jonathon A. Leipsic, Suhny Abbara, Stephan Achenbach, Daniel S. Berman, Marcio Bittencourt, Matthew Budoff, Kavitha Chinnaiyan, Andrew D. Choi, Brian Ghoshhajra, Jill Jacobs, Lynne Koweek, John Lesser, Christopher Maroules, Geoffrey D. Rubin, Frank J. Rybicki, Leslee J. Shaw, Michelle C. Williams, Eric Williamson, Charles S. White, Todd C. Villines, Ron Blankstein
Summary: Coronary Artery Disease Reporting and Data System (CAD-RADS) is a standardized reporting system for CCTA patients, aiming to guide patient management. The updated CAD-RADS 2.0 improves the initial reporting system by considering new technical developments, clinical trial data, and clinical guidelines.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengfa Huang, Jianwei Xiao, Xi Wang, Zuoqin Li, Ning Guo, Yun Hu, Xiang Li, Xiang Wang
Summary: The study aimed to evaluate the utility of an automatic postprocessing and reporting system based on CAD-RADS in suspected coronary artery disease (CAD) patients. The DL model showed good consistency with human readers in diagnosing CAD, with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 79.02%, 86.52%, 89.50%, 73.94%, and 82.08% respectively. The system can accurately and rapidly evaluate suspected CAD patients and has good consistency with grading by radiologists.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Davide Ippolito, Cammillo Talei Franzesi, Cecilia Cangiotti, Luca Riva, Andrea De Vito, Davide Gandola, Cesare Maino, Paolo Marra, Giuseppe Muscogiuri, Sandro Sironi
Summary: This study evaluated the inter-observer agreement of the CAD-RADS reporting system and compared the image quality between MBIR and IR in low-dose CCTA. The results showed excellent inter-observer agreement for CAD-RADS and better image quality with MBIR. This implies that MBIR can help improve the evaluation of CAD-RADS.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hallie Whalen, Rydhwana Hossain, Jean Jeudy, Charles S. White
Summary: The survey revealed that less than half of surveyed members of cardiovascular imaging societies use the CAD-RADS reporting system four years after its introduction, regardless of practice model and range of practice experience with cardiac computed tomography.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Pengyuan Zhu, Haitao Huang, Tian Xie, Huoqi Liang, Xing Li, Xingyi Li, Hao Dong, Xiaoqiang Yu, Chunqiu Xia, Chongjun Zhong, Zhibing Ming
Summary: In this study, we identified 5 hub genes associated with the development of coronary artery disease (CAD) and successfully established a diagnostic model with a sensitivity of 92.59%.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physiology
Parastoo Dehkordi, Erwin P. Bauer, Kouhyar Tavakolian, Zhen G. Xiao, Andrew P. Blaber, Farzad Khosrow-Khavar
Summary: This study presents a non-invasive solution to identify patients with coronary artery disease (CAD) through the analysis of heart linear acceleration and angular velocity data using a neural network model. The SCG model showed better performance in predicting CAD risk and may be suitable as a portable at-home CAD screening tool.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiun-Yiing Hu, Peter J. Bergquist, Rydhwana Hossain, Alan M. Ropp, Seth Kligerman, Sagar B. Amin, Jacob W. Sechrist, Priya Patel, Jean Jeudy, Charles S. White
Summary: This study aimed to evaluate the interobserver reproducibility between cardiothoracic radiologists using the CAD-RADS to describe atherosclerotic burden on coronary CT angiography. Results showed moderate to good interobserver reproducibility, with higher agreement among fellows than attending radiologists. However, there was a slight decrease in agreement for clinical management categories.
JOURNAL OF THORACIC IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Takuya Mizukami, Jeroen Sonck, Koshiro Sakai, Brian Ko, Michael Maeng, Hiromasa Otake, Bon-Kwon Koo, Sakura Nagumo, Bjarne L. Norgaard, Jonathon Leipsic, Toshiro Shinke, Daniel Munhoz, Niya Mileva, Marta Belmonte, Hirofumi Ohashi, Emanuele Barbato, Nils P. Johnson, Bernard De Bruyne, Carlos Collet
Summary: This study evaluated the impact of coronary artery disease (CAD) patterns on acute percutaneous coronary intervention (PCI) results and found that PCI in vessels defined by pullback pressure gradient (PPG) as focal disease can achieve better outcomes than angiographic assessment of CAD patterns.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Mingxuan Li, Lin Qi, Yanglei Li, Shuyi Zhang, Lei Lin, Lijin Zhou, Wanlin Han, Xinkai Qu, Junfeng Cai, Maoqing Ye, Kailei Shi
Summary: This study reveals that pericardial adipose tissue is closely associated with the occurrence of coronary artery disease, mainly due to immune and inflammatory dysfunction. The identified hubgenes, predicted drugs, and miRNAs have potential as biomarkers and therapeutic targets for CAD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jade Geerlings-Batt, Zhonghua Sun
Summary: This study aimed to explore the relationship between coronary artery disease (CAD) and the angle between the right coronary artery (RCA) and the aorta. By measuring the coronary angles in normal and CAD cases, it was found that the RCA-aorta angle was significantly smaller in the CAD group, suggesting a relationship between narrow RCA-aorta angle and CAD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Ho Moon, Jong Woo Kim, Jun Ho Yang, Dong Hoon Kang, Sung Hwan Kim, Jae Jun Jung, Jong Hwa Ahn, Sung Eun Park, Kyung Nyeo Jeon, Joung Hun Byun
Summary: This study aimed to evaluate proximal left anterior descending coronary artery (LAD) disease using two factors: coronary artery tortuosity and bifurcation angle. The results showed that as the tortuosity and LM-LAD angle increased, the chances of proximal LAD lesions formation also increased. Therefore, d20*cos0 might be a useful predictor of proximal LAD stenosis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Psychiatry
Wole Akosile, Babangida Tiyatiye, David Colquhoun, Ross Young
Summary: This systematic literature review examines treatment interventions for coronary artery disease (CAD) patients with comorbid depression. The review found that antidepressant and/or psychotherapy did not significantly influence CAD outcomes in the overall population, and there was no difference between antidepressant use and aerobic exercises. Psychological and pharmacological interventions had a small effect on depression outcomes in CAD patients. Patient autonomy in treatment choice was associated with greater depression treatment satisfaction.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Cardiac & Cardiovascular Systems
Manish Motwani, Michelle C. Williams, Koen Nieman, Andrew D. Choi
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Letter
Cardiac & Cardiovascular Systems
Ruby Havistin, Suvasini Lakshmanan, Matthew J. Budoff
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Ilana S. Golub, Orly G. Termeie, Stephanie Kristo, Lucia P. Schroeder, Suvasini Lakshmanan, Ahmed M. Shafter, Luay Hussein, Dhiran Verghese, Jairo Aldana-Bitar, Venkat S. Manubolu, Matthew J. Budoff
Summary: This review provides a summary of global guidelines on coronary artery calcium (CAC) for atherosclerotic cardiovascular disease risk assessment in both clinical and preventive settings. The review compares recommendations from different cardiovascular societies worldwide and identifies common features. Although there are some differences in specific intervals and cut points, international guidelines emphasize the importance of CAC in both primary and secondary prevention of atherosclerotic cardiovascular disease. Understanding the similarities among international guidelines is crucial for clinicians to make informed decisions about personalized treatment.
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Matthew J. Budoff
Article
Cardiac & Cardiovascular Systems
Harpreet S. S. Bhatia, Robyn L. L. McClelland, Julie Denenberg, Matthew J. J. Budoff, Matthew A. A. Allison, Michael H. H. Criqui
Summary: This study evaluated the association between coronary artery calcium (CAC) density and cardiovascular disease risk across different levels of CAC volume. The combination of CAC density and volume improved risk prediction for coronary heart disease. Higher density was associated with lower risk at volume ≤ 130 mm(3), suggesting a potentially clinically useful cut point. Further research is needed to integrate these findings into a unified CAC scoring method.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Mark G. Rabbat, Suvasini Lakshmanan, Mina M. Benjamin, Gheorghe Doros, April Kinninger, Matthew J. Budoff, Deepak L. Bhatt
Summary: The EVAPORATE trial demonstrated that IPE significantly reduced plaque burden. This study assessed the impact of IPE on coronary physiology using FFRCT. The results showed that IPE improved coronary distal segment FFRCT, providing mechanistic insight into the clinical benefit observed in the REDUCE-IT trial.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, A. Maxim Bax, Fay Y. Lin, Stephan Achenbach, Daniele Andreini, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin J. DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Gilbert L. Raff, Ronen Rubinshtein, Todd C. Villines, Hyuk-Jae Chang, Daniel S. Berman, James K. Min, Jeroen J. Bax, Leslee J. Shaw, Alexander R. van Rosendael
Summary: This study found that women develop coronary atherosclerosis approximately 12 years later than men, and post-menopausal women in the highest atherosclerotic burden group have a significantly higher risk for major adverse cardiovascular events (MACE) compared to men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gianluca Pontone, Saima Mushtaq, Subhi J. Al'Aref, Daniele Andreini, Andrea Baggiano, Arzu Canan, Joao L. Cavalcante, Anjali Chelliah, Marcus Chen, Andrew Choi, Dey Damini, Carlo Nicola De Cecco, Kanwal M. Farooqi, Maros Ferencik, Gudrun Feuchtner, Harvey Hecht, Heidi Gransar, Marton Kolossv, Jonathon Leipsic, Michael T. Lu, Mohamed Marwan, Ming-Yen Ng, Pal Maurovich-Horvat, Prashant Nagpal, Ed Nicol, Jonathan Weir-McCall, Seamus P. Whelton, Michelle C. Williams, Anna Reid, Timothy A. Fairbairn, Todd Villines, Rosemarie Vliegenthart, Armin Arbab-Zadeh
Summary: This review provides a summary of key articles published in the Journal of Cardiovascular Computed Tomography (JCCT) in 2022, focusing on those with significant scientific and educational impact. The JCCT has experienced growth in terms of submissions, published manuscripts, citations, downloads, social media presence, and impact factor. The selected articles in this review highlight the role of cardiovascular computed tomography (CCT) in detecting subclinical atherosclerosis, assessing stenosis relevance, and planning invasive procedures. It also includes sections on CCT in infants, patients with congenital heart disease, women, and the importance of CT training. Additionally, important consensus documents and guidelines published in JCCT last year are highlighted.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Review
Cardiac & Cardiovascular Systems
Neil Bodagh, Michelle C. Williams, Keeran Vickneson, Ali Gharaviri, Steven Niederer, Steven E. Williams
Summary: Cardiac computed tomography accurately depicts the structure and function of the atria, playing a crucial role in personalized treatment for patients with atrial fibrillation.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Jacek Kwiecinski, Marton Kolossvary, Evangelos Tzolos, Mohammed N. Meah, Philip D. Adamson, Nikhil V. Joshi, Michelle C. Williams, Edwin J. R. van Beek, Daniel S. Berman, Pal Maurovich-Horvat, David E. Newby, Marc R. Dweck, Damini Dey, Piotr J. Slomka
Summary: This study investigated the predictive ability of F-18-sodium fluoride positron emission tomography and radiomics-based precision coronary plaque phenotyping derived from coronary computed tomography angiography in risk stratification of patients with coronary artery disease. The results showed that the morphological features of coronary plaques, quantitative plaque volumes, and disease activity on F-18-sodium fluoride positron emission tomography were additive predictors of myocardial infarction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Nozomi Kotoku, Bjarne L. Norgaard, Scot Garg, Koen Nieman, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A. Taylor, Jonathon A. Leipsic, Edward D. Nicol, Nicolo Piazza, Carl J. Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima Mushtaq, Marta Belmonte, Darius Dudek, Adriana Zlahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J. Budoff, Johan de Mey, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomographic angiography (CCTA) has become the preferred investigation for determining the presence and haemodynamic significance of coronary artery disease. It can rule out atherosclerosis or detect subclinical plaque in patients without significant epicardial obstruction, and provide risk classification. For ischaemic non-obstructive coronary arteries, non-invasive imaging, including CCTA, is also expected. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining disease complexity, vessel size, lesion length, tissue composition of the atherosclerotic plaque, and the best fluoroscopic viewing angle.
Review
Cardiac & Cardiovascular Systems
Pamela Pina, Daniel Lorenzatti, Rita Paula, Jonathan Daich, Aldo L. Schenone, Carlos Gongora, Mario J. Garcia, Michael J. Blaha, Matthew J. Budoff, Daniel S. Berman, Salim S. Virani, Leandro Slipczuk
Summary: Atherosclerotic cardiovascular disease (ASCVD) is a ongoing epidemic, primarily caused by lipid abnormalities. Despite being asymptomatic, most individuals who experience a first ASCVD event do not receive preventative therapies. Risk calculators based on traditional risk factors have been the cornerstone of primary prevention, but they often misclassify individuals, resulting in ineffective use of lipid-lowering medication or missed opportunities for prevention. The development of coronary artery calcium scoring (CAC) and CT coronary angiography (CCTA) provide tools to visualize coronary plaque and guide personalized lipid management.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Anandita Agarwala, Jaideep Patel, Michael Blaha, Miguel Cainzos-Achirica, Khurram Nasir, Matthew Budoff
Summary: South Asian individuals, especially those in the United States and other Westernized countries, have a higher risk of ASCVD and ASCVD-related mortality. The use of coronary artery calcium (CAC) scoring can improve risk stratification and the delivery of preventive therapies among South Asian individuals, as it is a cost-effective and highly reproducible marker of subclinical atherosclerosis.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)