Article
Biochemistry & Molecular Biology
Marta Karkoszka, Jakub Rok, Klaudia Banach, Justyna Kowalska, Zuzanna Rzepka, Dorota Wrzesniok
Summary: This study evaluated the influence of Meloxicam and UVAR on skin cell homeostasis. The results showed that co-treatment with Meloxicam and UVAR inhibited skin cell proliferation and caused morphological changes. Additionally, Meloxicam and UVAR disrupted redox homeostasis by lowering the intracellular level of reduced thiols. The study revealed that the phototoxic activity of Meloxicam is associated with oxidative stress induction and disruptions in cell homeostasis.
Article
Chemistry, Multidisciplinary
Abigail L. Whittock, Xuefei Ding, Xavier E. Ramirez E. Barker, Nazia Auckloo, Rebecca A. Sellers, Jack M. Woolley, Krishnan Tamareselvy, Marine Vincendet, Christophe Corre, Emma Pickwell-MacPherson, Vasilios G. Stavros
Summary: Biomimicry is playing a crucial role in researching new materials for various applications. This study focuses on a crude extract from red algae, Palmaria palmata, which contains mycosporine-like amino acids - a type of photoprotective molecules. The researchers have applied this extract onto a surface and confirmed that it retains its photoprotection and light-to-heat conversion properties. They also demonstrated how to monitor stability in real-world applications using terahertz spectroscopy.
Article
Cell Biology
Julie Rorteau, Fabien P. Chevalier, Sebastien Bonnet, Theo Barthelemy, Amandine Lopez-Gaydon, Lisa S. Martin, Nicolas Bechetoille, Jerome Lamartine
Summary: This study investigates whether primary normal human dermal fibroblasts retain age-related characteristics when cultured in 2D monolayer and if they can be used as a relevant model for aging research. The findings suggest that as age increases, the cells exhibit decreased population doubling capacities, reduced clonogenic ability, impairment in extracellular matrix production, and modifications in respiratory metabolism. These alterations of cell features are related to the signs of dermis aging.
Article
Dermatology
Taihao Quan, Yaping Xiang, Yingchun Liu, Zhaoping Qin, Yan Yang, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher
Summary: The aging process affects the structure and function of dermal collagen, leading to thinning, fragility, wrinkles, laxity, impaired wound healing, and a microenvironment conducive to cancer. CCN1 protein is elevated in aged human skin, and transgenic mice expressing CCN1 in dermal fibroblasts display accelerated skin dermal aging. This mouse model provides a novel tool for understanding and studying the mechanisms of skin aging.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ugne Zlabiene, Juste Baranauskaite, Dalia M. Kopustinskiene, Jurga Bernatoniene
Summary: The study found that the multiple W/O/W emulsion loaded with self-preserving plant-based bioactives was safe for use in cosmetic products, as it showed no skin irritation, phototoxicity, skin inflammation, or sensitization potential. The safety evaluation of cosmetic ingredients of natural or organic origin can be easily conducted using the reconstructed human skin model EpiDerm (TM), similar to the well-defined chemicals used in the cosmetics industry.
Article
Immunology
Naoko Takamura, Ludivine Renaud, Willian Abraham da Silveira, Carol Feghali-Bostwick
Summary: Systemic sclerosis is an autoimmune disease characterized by vasculopathy and excessive fibrosis, with limited treatment options available. Research suggests that abnormal regulation of MCHR1 may play a role in the pathogenesis of SSc, and inhibiting MCHR1 could be a novel therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Quan M. Phan, Lucia Salz, Sam S. Kindl, Jayden S. Lopez, Sean M. Thompson, Jasson Makkar, Iwona M. Driskell, Ryan R. Driskell
Summary: In this study, the researchers used multimodal single-cell approaches, epigenetic assays, and allografting techniques to investigate the differentiation mechanism of dermal fibroblast progenitors (DFPs) during skin development. They found that the overall transcription profile of DFPs is repressed by H3K27me3 and that they are unable to reform the skin in allograft assays. Further analysis revealed that the H3K27me3 demethylase, Kdm6b/Jmjd3, plays a role in derepressing DFPs during murine skin development. This study provides a multimodal understanding of DFP differentiation and offers a novel multiomics search tool.
Review
Physiology
Sun Hye Shin, Yoon Hwan Lee, Nark-Kyoung Rho, Kui Young Park
Summary: Skin aging is a complex process involving both internal and external factors. Internal aging is associated with programmed aging and cellular senescence caused by oxidative stress and damage. External aging is a result of environmental factors like UV radiation and pollution, leading to DNA damage and cell dysfunction. Understanding these mechanisms is crucial for developing effective anti-aging treatments.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Plant Sciences
Ramona Fecker, Ioana Zinuca Magyari-Pavel, Ileana Cocan, Ersilia Alexa, Iuliana Maria Popescu, Adelina Lombrea, Larisa Bora, Cristina Adriana Dehelean, Valentina Buda, Roxana Folescu, Corina Danciu
Summary: This study evaluated the oxidative stability and protective effect of a mixture of Helianthus annuus L. and Oenothera biennis L. oils on 3D tissue models. The results showed that the mixture had good oxidative stability and did not cause skin irritation or phototoxicity.
Article
Pharmacology & Pharmacy
Yang Yang, Ann-Marie Ako-Adounvo, Jiang Wang, Sergio G. Coelho, Steven A. Adah, Murali K. Matta, David Strauss, Theresa M. Michele, Jian Wang, Patrick J. Faustino, Thomas O'Connor, Muhammad Ashraf
Summary: This study compares two in vitro permeation test methods and examines the correlation between in vitro and in vivo absorption of sunscreen UV filters. The results show that all UV filters are absorbed by the skin following a single-dose application, and the amount of absorption varies among different filters. The in vitro permeation test using a single finite dose and heat-separated human epidermis correlates well with clinical data.
Article
Agriculture, Multidisciplinary
Takashi Ito, Mao Odama, Eiji Maegawa, Kohsuke Suzuki, Yujiro Fujii, Reika Maeda, Shigeru Murakami
Summary: This study investigated the effects of pentacyclic triterpenoids, including betulinic acid (BA), on the cellular proliferation and senescence of normal human dermal fibroblasts (NHDFs). BA treatment increased the proliferation of young fibroblasts and reduced the proportion of senescent cells in high-passage NHDFs. The downregulation of interferon (IFN)-inducible genes, including IFIT1, IFITM1, IFI6, MX1, and OAS2, by BA suggested the suppression of the type I IFN signaling pathway. BA also downregulated the expression of the IRF9 transcriptional factor downstream of the type 1 IFN signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Polymer Science
Manira Maarof, Masrina Mohd Nadzir, Lau Sin Mun, Mh Busra Fauzi, Shiplu Roy Chowdhury, Ruszymah Bt Hj Idrus, Yogeswaran Lokanathan
Summary: The study characterized 3D collagen hydrogels fortified with dermal fibroblast-conditioned medium (DFCM) as a skin substitute. The Col/C4S/DFCM constructs showed lower turbidity and porosity compared to control groups, indicating their potential for future skin therapeutic applications.
Article
Pharmacology & Pharmacy
Mohsin Qureshi, Abdul Qadir, Mohd Aqil, Yasmin Sultana, Musarrat Husain Warsi, Mohd Vaseem Ismail, Sushama Talegaonkar
Summary: This study aimed to develop and optimize an NLC formulation for topical berberine administration, which showed promising efficacy in treating acne vulgaris with low skin irritation. Various tests including in-vitro drug release, skin penetration investigation, skin irritation, anti-inflammatory, and anti-acne studies were conducted, demonstrating the potential of the developed NLC gel as a safe and effective treatment for acne vulgaris.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Cell Biology
Marta Gerasymchuk, Gregory Ian Robinson, Alyssa Groves, Lucie Haselhorst, Sanjana Nandakumar, Cora Stahl, Olga Kovalchuk, Igor Kovalchuk
Summary: Through research on the effects of pCBs on skin rejuvenation, it was found that THC and CBD can promote cell growth and reduce senescence within a certain concentration range. They also alter nuclear architecture and genes related to cell cycle regulation and ECM production. In addition, compared to other common anti-aging substances, THC and CBD showed better wound healing effects in replicative senescent skin fibroblasts.
Article
Dermatology
P. B. Lima, J. A. F. Dias, A. C. C. Esposito, L. D. B. Miot, H. A. Miot
Summary: The study demonstrates that oral intake of 75 mg Pycnogenol per day can enhance the efficacy of broad-spectrum sunscreen and the triple combination for treating facial melasma in women, with good tolerability.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Chemistry, Applied
Xin Ying Lee, Chee Chin Chu, Zafarizal Aldrin Bin Azizul Hasan, Siaw Kim Chua, Kar Lin Nyam
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2019)
Article
Food Science & Technology
Chee Chin Chu, Chin Ping Tan, Kar Lin Nyam
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2019)
Article
Chemistry, Applied
Chee Chin Chu, Zafarizal Aldrin Bin Azizul Hasan, Siaw Kim Chua, Kar Lin Nyam
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2020)
Article
Biotechnology & Applied Microbiology
Chee Chin Chu, Sook Chin Chew, Kar Lin Nyam
Summary: Kenaf is an economically viable and ecologically friendly alternative fiber crop, with bioactive compounds found in its seeds oil, seeds extract, and leaves extract offering antioxidants and medicinal benefits for pharmaceutical and cosmetic industries. Encapsulation technologies applied on kenaf derivatives can help develop highly effective cosmetic formulations, improving stability and functionality for cosmeceutical applications.
FOOD AND BIOPRODUCTS PROCESSING
(2021)
Article
Chemistry, Medicinal
Chee Chin Chu, Zafarizal Aldrin Bin Azizul Hasan, Chin Ping Tan, Kar Lin Nyam
Summary: The study investigated the antiaging potential of NLC-TRF sunscreen, revealing its significant antioxidant and inhibition activities against collagenase, elastase, and MMP-1. In addition, it was found to promote the expression of fibroblast regeneration genes, supporting its therapeutic potential in antiaging.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Applied
Chee Chin Chu, Kar Lin Nyam
Summary: Seed oils are in high demand for photoprotective skincare products, as they contain natural antioxidants and contribute to skin health. The addition of specific bioactive compounds from seed oils provides a better understanding of their benefits in sunscreen formulation, including their synergistic effects with antioxidants, antiaging properties, anti-inflammatory effects, and potential hormetic effects.
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Article
Agricultural Engineering
Chee Chin Chu, Chin Ping Tan, Zafarizal Aldrin Azizul Hasan, Kar Lin Nyam
Summary: This study optimized the ratio of UV filters in kenaf seed oil nanocarrier to develop a sunscreen formulation. The nanocarrier showed high encapsulation efficiency for UV filters and when added to a tocotrienol-rich cream, it exhibited no cytotoxicity and provided both sun protection and cellular antioxidant capacity. The application of nanocarriers in the cream also resulted in significant protein upregulation and downregulation, indicating its potential as a promising delivery system in sunscreen formulations.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Agricultural Engineering
Chee Chin Chu, Kar Lin Nyam
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Chemistry, Applied
Teik Siun Ong, Chee Chin Chu, Chin Ping Tan, Kar Lin Nyam
JOURNAL OF OLEO SCIENCE
(2020)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
