Review
Health Care Sciences & Services
Claudia C. Orelio, Pauline Heus, Judith J. Kroese-van Dieren, Rene Spijker, Barbara C. van Munster, Lotty Hooft
Summary: This study systematically reviewed the effectiveness of de-implementation strategies aimed at reducing inappropriate PPI use in hospitalized, non-intensive care unit patients. The majority of studies included in the review utilized educational interventions in combination with other strategies, targeting primarily providers. Results showed a small to moderate reduction in inappropriate PPI prescriptions or use in most studies.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Joe S. Smith, Jessica Gebert, Kailee Bennett, Lisa Sams Ebner, Ryan Flynn, Pierre-Yves Mulon, Lainey Harvill, Olivia Grace Escher, Amanda Jo Kreuder, Joan Bergman, Sherry Cox
Summary: This study aimed to report the pharmacokinetic parameters and pharmacodynamic effect of esomeprazole in sheep after single intravenous dosing. Esomeprazole was rapidly eliminated in sheep and had a significant effect on increasing abomasal pH. However, further studies are needed to develop a clinical management approach for the use of esomeprazole in sheep.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Medicine, General & Internal
Karen Clarke, Nicole Adler, Deepak Agrawal, Dimpal Bhakta, Suchita Shah Sata, Sarguni Singh, Arjun Gupta, Amit Pahwa, Emily Pherson, Alexander Sun, Frank Volpicelli, Hyung J. Cho
Summary: Proton pump inhibitors are widely used for the treatment of acid-related gastrointestinal disorders and stress ulcer prophylaxis. However, their use may lead to significant complications such as fractures, Clostridium difficile infection, acute kidney injury, chronic kidney disease, and hypomagnesemia. In the hospital setting, proton pump inhibitors are often overused and inappropriately continued after discharge.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Surgery
Brigitte Anderson, Tingting Zhan, Luke Swaszek, Caroline Sanicola, Neil King, Aurora Pryor, Konstantinos Spaniolas, Renee Tholey, Francesco Palazzo, Alec Beekley, Talar Tatarian
Summary: This study evaluated the incidence of marginal ulcers (MUs) after primary and secondary Roux-en-Y Gastric Bypass (RYGB). The results showed that patients who underwent conversion of Sleeve Gastrectomy to RYGB had a higher incidence of MUs compared to those who had primary RYGB or Gastric Banding to RYGB. Furthermore, the time to MU development was significantly shorter in patients who underwent conversion surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Ophelie Bacoeur-Ouzillou, Julie Perinel, Elise Pelascini, Mourad Abdallah, Gilles Poncet, Arnaud Pasquer, Maud Robert
Summary: This study retrospectively analyzed the management strategies and outcomes of marginal ulcers in a bariatric surgery center. One Anastomosis Gastric Bypass (OAGB) was identified as the only risk factor for recurrence, and conversion to Roux-en-Y Gastric Bypass (RYGB) seemed to be effective for healing.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Immunology
Emanuele Dilaghi, Mario Bellisario, Gianluca Esposito, Marilia Carabotti, Bruno Annibale, Edith Lahner
Summary: The use of PPIs before the diagnosis of AAG appears to significantly increase the risk of subsequent development of GNLs. Considering the common misuse of PPIs, physicians should regularly reassess the appropriateness of ongoing PPI therapy, especially in patients with a clinical suspicion of or already diagnosed AAG.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Aline Schaefer, Philipp Gehwolf, Katrin Kienzl-Wagner, Fergul Cakar-Beck, Heinz Wykypiel
Summary: Linear-stapled gastrojejunostomy is preferred over circular-stapled gastrojejunostomy in reducing the risk of anastomotic ulcers development, while smoking cessation can minimize the risk for anastomotic ulcers and is essential in treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Azizullah Beran, Mohammad Shaear, Saif Al-Mudares, Ishna Sharma, Reem Matar, Mohammad Al-Haddad, Marita Salame, Ray Portela, Benjamin Clapp, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: This meta-analysis identified predictors of marginal ulcer (MU) after Roux-en-Y gastric bypass (RYGB) and found that Helicobacter pylori (HP) infection, smoking, and diabetes mellitus were significant predictors. Smoking cessation, optimizing glycemic control, and eradication of HP infection can reduce the risk of MU among high-risk patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Physiology
Lisanne M. M. Gommers, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Summary: Proton pump inhibitors (PPIs) are the first-line treatment for gastric acid-related disorders, but they can cause hypomagnesemia. The exact mechanism by which PPIs cause impaired magnesium absorption is still unknown, but current experimental evidence suggests reduced magnesium solubility in the intestinal lumen and changes in the expression and activity of key transporter proteins in the small intestine and colon.
Article
Veterinary Sciences
Jeff D. Olivarez, Pierre-Yves Mulon, Lisa S. Ebner, Haley Cremerius, Channing Cantrell, Rebecca Rahn, Windy Soto-Gonzalez, Joan Bergman, Sherry Cox, Jonathan P. Mochel, Amanda J. Kreuder, Joe S. Smith
Summary: The objective of this study was to estimate the pharmacokinetic parameters of pantoprazole in neonatal calves and investigate its effect on abomasal pH. The results showed that the pharmacokinetic parameters of pantoprazole in neonatal calves were similar to previous reports. Additionally, pantoprazole significantly increased abomasal pH. These findings suggest that pantoprazole may be a potential treatment/preventative for abomasal ulcers.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Christopher B. Crawford, Leslie M. Schuh, Margaret M. Inman
Summary: This study compares two surgical methods for repairing ulcer perforations after Roux-en-Y gastric bypass (RYGB) surgery. The results show that revision gastrojejunostomy is a more effective treatment option for patients with ulcer recurrence, with comparable short-term morbidity compared to suturing with or without an omental patch.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Medicine, General & Internal
Marita Salame, Noura Jawhar, Amanda Belluzzi, Mohammad Al-Kordi, Andrew C. Storm, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: Marginal ulcers (MU) are a potential complication following Roux-en-Y gastric bypass (RYGB) surgery, with an average prevalence of 4.6%. Early identification and prompt intervention are crucial to prevent further complications. MU is a complex condition influenced by factors such as smoking, Helicobacter pylori infection, NSAID use, and pouch size. Diagnosis is typically made through endoscopy, and treatment involves modifying risk factors and medical therapy with proton pump inhibitors. Surgical intervention may be necessary for complicated ulcers, while endoscopic procedures and vagotomy may be considered for recurrent or challenging cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Yoko Takedani, Tsukasa Nakamura, Noriko Fukiwake, Toshihiro Imada, Junji Mashino, Takeshi Morimoto
Summary: Antibiotic-associated diarrhea (AAD) is common among elderly inpatients with pneumonia, with beta-lactamase inhibitors and proton pump inhibitors being associated with AAD in this population according to a retrospective cohort study conducted in a Tertiary Care Hospital in Japan.
Article
Surgery
Adam Di Palma, Benjamin Liu, Azusa Maeda, Mehran Anvari, Timothy Jackson, Allan Okrainec
Summary: Smoking history, use of immunosuppressive medication, and preoperative NSAID use were significantly associated with an increased risk of developing recalcitrant marginal ulcers. Patients undergoing revisional surgery reported symptom resolution in only 36% of cases, with 57% developing recurrent ulcers. Additional evidence is needed to guide perioperative management of bariatric patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Pharmacology & Pharmacy
Wan-Ying Lin, Shih-Syuan Wang, Yi-No Kang, Andrea S. Porpiglia, Yu Chang, Chin-Hsuan Huang, Ronak Bhimani, Eahab Abdul-Lattif, Muneeba Azmat, Tsu-Hsien Wang, Yu-Shiuan Lin, Yu-Cheng Chang, Kuan-Yu Chi
Summary: This study aimed to evaluate the impact of proton pump inhibitors (PPI) on colorectal cancer (CRC) patients undergoing chemotherapy. The study found that PPI use did not significantly affect overall survival and progression-free survival in patients receiving capecitabine-based regimens; however, concurrent use of PPI in early-stage cancer patients may lead to an increased disease progression rate. For patients receiving fluorouracil-based regimens, simultaneous use of PPI may contribute to a slightly higher all-cause mortality.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Fauzi Feris, Alison McRae, Todd A. Kellogg, Travis McKenzie, Omar Ghanem, Andres Acosta
Summary: The aim of this study was to review the hormonal and histologic changes observed after RYGB surgery, and to identify gaps and future research directions. The study provides a comprehensive understanding of the food intake regulatory adaptations occurring after RYGB surgery.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Pearl Ma, Ahmet Vahibe, Travis McKenzie, Maria D. Hurtado Andrade, Robert A. Vierkant, Kelvin Higa, Michael Kendrick, Omar M. Ghanem
Summary: The study aimed to assess whether metabolic and bariatric surgery (MBS) reduces the use of immunosuppressant agents in patients with rheumatic diseases (RD). The results showed that a significant proportion of patients stopped using prednisone and/or reduced the use of immunosuppressant agents during the follow-up period. The findings of this study indicate that MBS may have a positive impact on the treatment and disease management of patients with rheumatic diseases.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Benjamin Clapp, John Corbett, Monica Jordan, Ray Portela, Omar M. Ghanem
Summary: The SADI-S procedure has higher perioperative complications compared to RYGB and SG, but comparable outcomes to BPD/DS.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Benjamin Clapp, Omar M. Ghanem, Michael Edwards, Spyridon Giannopoulos, Victoria Lyo, Nancy Puzziferri, Dimitrios Stefanidis
Summary: The American Society of Metabolic and Bariatric Surgery (ASMBS) Foundation has been funding competitive proposals by ASMBS members since 2004. This study evaluated the factors associated with grant completion success and the barriers encountered by investigators.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Tala Mahmoud, Azizullah Beran, Fateh Bazerbachi, Reem Matar, Veeravich Jaruvongvanich, Farah Abdul Razzak, Donna Maria Abboud, Eric J. Vargas, John A. Martin, Todd A. Kellogg, Omar M. Ghanem, Bret T. Petersen, Michael J. Levy, Ryan J. Law, Vinay Chandrasekhara, Andrew C. Storm, Louis M. Wong Kee Song, Navtej S. Buttar, Barham K. Abu Dayyeh
Summary: Lumen-apposing metal stents (LAMS) are an effective therapeutic option for the management of benign gastrointestinal strictures, providing high technical and early clinical success. However, a high rate of re-intervention is required after LAMS removal.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Surgery
Omar M. Ghanem
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Surgery
Benjamin Clapp, Kamal Abi Mosleh, John Corbett, Karl Hage, Rachel L. Moore, Helmuth Billy, Jaime Ponce, Omar M. Ghanem
Summary: A retrospective analysis was conducted on patients who underwent SADI-S or OAGB procedures using the MBSAQIP database. The study found that SADI-S had higher readmission rates and more Clavien-Dindo grade 2 and 4b complications.
Article
Surgery
Spyridon Giannopoulos, Dimitrios I. Athanasiadis, Edward Hernandez, Timothy C. Baumgartner, Bhavani Pokala, Ambar Banerjee, Jennifer N. Choi, Dimitrios Stefanidis
Summary: In a randomized controlled trial, patients undergoing bariatric surgery were divided into two groups, with one group guided by a risk/benefit calculator and the other group receiving traditional surgeon-led counseling. The study found that while most patients found the calculator useful, its use did not influence their procedure choice.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Spyridon Giannopoulos, Seyed Mohammad Kalantar Motamedi, Dimitrios I. Athanasiadis, Benjamin Clapp, Victoria Lyo, Omar Ghanem, Michael Edwards, Nancy Puzziferri, Dimitrios Stefanidis
Summary: Based on a web-based survey, researchers found significant variability in venous thromboembolism (VTE) prophylaxis practices among metabolic/bariatric surgeons, possibly due to limited available evidence. Controversy still exists regarding the ideal methods, dosage, and duration of VTE prophylaxis after metabolic/bariatric surgery. Large prospective clinical trials are necessary to establish optimal practices for risk stratification and prophylaxis of VTE in bariatric surgery patients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Spyridon Giannopoulos, Keith Makhecha, Sathvik Madduri, Felix Garcia, Timothy C. C. Baumgartner, Dimitrios Stefanidis
Summary: Percutaneous cholecystostomy (PC) tube insertion is an effective temporary treatment for acute cholecystitis (AC) before laparoscopic cholecystectomy (LC). The optimal time gap between PC implantation and LC has not been determined. A retrospective analysis of adult patients who underwent PC followed by LC for AC showed that LC was performed after a median of 65 [48 - 96.5] days following PC placement. While no deaths or reoperations occurred within 30 days, some patients required readmission and reintervention. A longer interval between PC and LC did not affect perioperative outcomes but was associated with longer ICU stay.
Review
Gastroenterology & Hepatology
Azizullah Beran, Mohammad Shaear, Saif Al-Mudares, Ishna Sharma, Reem Matar, Mohammad Al-Haddad, Marita Salame, Ray Portela, Benjamin Clapp, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: This meta-analysis identified predictors of marginal ulcer (MU) after Roux-en-Y gastric bypass (RYGB) and found that Helicobacter pylori (HP) infection, smoking, and diabetes mellitus were significant predictors. Smoking cessation, optimizing glycemic control, and eradication of HP infection can reduce the risk of MU among high-risk patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Spyridon Giannopoulos, Keith Makhecha, Sathvik Madduri, Felix Garcia, Timothy C. Baumgartner, Dimitrios Stefanidis
Summary: Acute cholecystitis is a common disease in clinical practice. Patients who are not suitable for surgery may benefit from early percutaneous cholecystostomy drainage followed by interval cholecystectomy, but the optimal timing between the two procedures is still uncertain. This study aimed to investigate the impact of the duration between percutaneous cholecystostomy and interval cholecystectomy on perioperative outcomes and identify the optimal timing to minimize complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Letter
Surgery
Hayato Nakanishi, Ray Portela, Benjamin Clapp, Omar M. Ghanem
BRITISH JOURNAL OF SURGERY
(2023)
Letter
Surgery
Omar M. Ghanem, Ray Portela, Benjamin Clapp
BRITISH JOURNAL OF SURGERY
(2023)