Article
Microbiology
Fen-Ting Liu, Shuo Yang, Zi Yang, Ping Zhou, Tianliu Peng, Jingwen Yin, Zhenhong Ye, Hongying Shan, Yang Yu, Rong Li
Summary: This study reports distinct alterations in the vaginal, cervical, and uterine microbiota in patients with RSA. The study suggests that changes in the microbiota in the uterine cavity may be associated with altered cytokine levels, potentially contributing to RSA pathogenesis. Furthermore, the study highlights the need for simultaneous sampling of both endometrial tissue and uterine lavage fluid for a comprehensive understanding of microbial colonization in the uterine cavity.
MICROBIOLOGY SPECTRUM
(2022)
Review
Cell Biology
Erqing Huang, Lijuan Chen
Summary: RNA m(6)A modification plays a crucial role in the pathophysiological mechanism of female reproductive diseases, including oogenesis, embryonic growth, and various gynecological tumors such as cervical cancer, endometrial cancer, and ovarian cancer. This review summarizes the recent research results on m(6)A in female reproductive biology and pathophysiology, and discusses future research directions and clinical applications of m(6)A-related targets. It is expected to enhance our understanding of the cellular mechanisms, diagnostic biomarkers, and potential therapeutic strategies for female reproductive system diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Genetics & Heredity
Xiaohua Liu, Jiabao Wu, Hua Nie, Xiaoli Zhu, Ge Song, Lu Han, Weibing Qin
Summary: The study investigated dysregulated circRNAs, miRNAs, and mRNAs in the decidua of patients with URSA, identifying their potential roles in immunologic functions. A ceRNA network involving circRNAs positively correlated with MFGE8 expression was observed, suggesting a potential impact on the development of URSA.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Jianyu Gan, Ting Gu, Huaqiang Yang, Zheng Ao, Gengyuan Cai, Linjun Hong, Zhenfang Wu
Summary: This review discusses the function and mechanism of micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in regulating spontaneous abortion (SA). It suggests the existence of a competitive endogenous RNA (ceRNA) regulatory network in the onset and development of SA. Understanding this network is important for the search of potential RNA markers for SA diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Ahmed Mohamedain, Duria A. Rayis, Nadiah AlHabardi, Ishag Adam
Summary: The study demonstrated that previous spontaneous abortion reduced the risk of developing preeclampsia, while women with a history of preeclampsia had a higher risk of recurrence.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Immunology
Qiu-Yan Zhao, Qing-Hui Li, Yao-Yao Fu, Chun-E Ren, Ai-Fang Jiang, Yu-Han Meng
Summary: This study aims to explore the connection between decidual macrophages and RSA by analyzing their phenotypes and functions. The findings contribute to understanding the mechanisms of RSA and have significant implications for its prevention and management.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jingni Wu, Xiaoling Fang, Hongyan Huang, Wei Huang, Lei Wang, Xiaomeng Xia
Summary: Novel biomarkers for the diagnosis and treatment of endometriosis were identified through RNA sequencing and construction of a ceRNA network. Twelve potential exosomal RNA-based biomarkers were discovered, providing insight into the molecular pathways of endometriosis.
Article
Immunology
Sainan Zhang, Jinli Ding, Jiayu Wang, Tailang Yin, Yan Zhang, Jing Yang
Summary: This study demonstrated for the first time that decreased expression of CXCL5 in human villous tissue is correlated with RSA. Additionally, it was found that estrogen, progesterone, human chorionic gonadotropin, and decidual stromal cells can regulate the expression of CXCL5 and chemokine receptor 2 (CXCR2) in trophoblast cells in a cell manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Zhilan Liu, Si Sun, Haijing Xu, Xiaoxin Zhang, Chao Chen, Ruojin Fu, Congcong Li, Feng Guo, Aimin Zhao
Summary: Antibody typing and treatment can improve live birth rate in Chinese patients with APS-related RSA. The combination of anticoagulant and anti-inflammatory treatment leads to a higher live birth rate in the treatment of APS-related RSA.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Yang Yang, Haoran Liu, Yue Zhao, Chen Geng, Lan Chao, Aijun Hao
Summary: This study found that the dysregulation of decidual macrophages was associated with recurrent spontaneous abortion (RSA). It was observed that the expression of Grim-19 was decreased and the expression of autophagy related proteins was increased in decidual macrophages of RSA patients. Downregulation of Grim-19 promoted the expression of autophagy related proteins and proinflammatory cytokines, as well as enhanced phagocytic activity. This study provides insight into a novel mechanism for the occurrence of RSA through the regulation of Grim-19 and autophagy by macrophages.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Olga P. Lebedeva, Vasily N. Popov, Mikhail Y. Syromyatnikov, Natalia N. Starkova, Alexander Y. Maslov, Olesya N. Kozarenko, Mariya V. Gryaznova
Summary: Miscarriage is a common cause of reproductive loss and can have significant physical and psychological complications. The role of the vaginal and uterine microbiome in these complications is not well understood. This review analyzes published data on the function of the female reproductive tract microbiome in the pathogenesis of early miscarriages. The findings suggest that further research is needed to better understand the impact of the microbiome on miscarriages and develop new approaches for prevention.
Review
Biochemistry & Molecular Biology
Sahar Esfandyari, Hoda Elkafas, Rishi Man Chugh, Hang-soo Park, Antonia Navarro, Ayman Al-Hendy
Summary: Cell-cell communication through exosomes plays a crucial role in female reproductive diseases, offering potential therapeutic targets and biomarkers for regulating reproductive system development and pregnancy outcomes in abnormal conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Seo-Jin Park, Ji-You Min, Jeom-Soon Kang, Byung-Guk Yang, Seung-Yong Hwang, Sung-Hee Han
Summary: This study investigated the demographic data and karyotypes of 19,000 couples who experienced recurrent spontaneous abortion (RSA). The results showed that 4.44% of the couples had chromosomal aberrations, with females being more likely to have them. The mean age of individuals with chromosomal aberrations was younger, and there were significant correlations between sex and age distribution and the subtypes of chromosomal aberrations.
FERTILITY AND STERILITY
(2022)
Article
Environmental Sciences
Jie Zheng, Yanxia Wang, Baohong Mao, Yamei Li, Jing Li, Jie Yang, Zhaoyan Meng, Bin Luo
Summary: This study found that indoor air pollution may be an important risk factor for recurrent spontaneous abortion (RSA), which may be intensified by poor psychological status. Additionally, using ventilation equipment during cooking can be a protective factor for RSA.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemical Research Methods
Lei Zhang, Qian Li, Yan Su, Xinyuan Zhang, Jialin Qu, Dan Liao, Qin Zou, Hua Zou, Xiaoli Liu, Chunli Li, Junlin He
Summary: This study aimed to reveal the pathogenesis of unexplained recurrent spontaneous abortion (URSA) by analyzing differential protein expression profiles in decidual tissue. The findings highlighted the potential role of cytoskeletal remodeling disorder in the failure of decidualization and provided valuable information for further research and potential therapeutic interventions.
JOURNAL OF PROTEOMICS
(2023)
Article
Clinical Neurology
Yitan Yao, Shengya Shi, Wenfei Li, Bei Luo, Yating Yang, Mengdie Li, Ling Zhang, Xiaoping Yuan, Xiaoqin Zhou, Huanzhong Liu, Kai Zhang
Summary: In this study, we found an uneven seasonal distribution of psychiatric admissions. The peak of schizophrenia admissions occurred in the winter, while depression and bipolar disorder admissions peaked in the fall and spring respectively. Admissions for childhood mood disorders peaked in the fall. Furthermore, the length of stay was also correlated with the season of admission, and this seasonal fluctuation differed between male and female populations.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Applied
Yuhan Huang, Min Li, Chenxi Shi, Zhanjun Liu, Bo Ren
Summary: In this study, NaA zeolite nanocrystalline aggregates with a size of 6 nm were successfully synthesized for the first time by refluxing at near room temperature and atmospheric pressure. The synthesized samples were characterized using various techniques, including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and N2 adsorption-desorption isotherms. The results showed that the synthesized NaA zeolite had high crystallinity and specific surface area, making them ideal for further development.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Immunology
Zhen-Zhen Lai, Wen-Jie Zhou, Jia-Wei Shi, Yu-Han Meng, Jiang-Nan Wu, Jiang-Feng Ye, Ting Peng, Chang-En Xu, Ming-Qing Li
Summary: Acute lung injury (ALI) is a common respiratory disease with high morbidity and mortality rate in pregnant women. The RANKL/RANK axis plays an essential role in LPS-induced ALI during pregnancy possibly through a variety of pathways.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Immunology
Zhi Lin, Jia-Lu Shi, Min Chen, Zi-Meng Zheng, Ming-Qing Li, Jun Shao
Summary: C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an important chemotactic factor that recruits macrophages for immune response. It is expressed at the maternal-fetal interface and has physiological regulators that maintain normal immune cell recruitment, tissue remodeling, and angiogenesis. However, abnormal levels of CCL2 have been associated with adverse pregnancy outcomes. This review focuses on CCL2 expression, regulatory mechanisms, and signaling pathways at the maternal-fetal interface to provide a comprehensive understanding of CCL2 in pregnancy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhen-Zhen Lai, Jie Zhang, Wen-Jie Zhou, Jia-Wei Shi, Hui-Li Yang, Shao-Liang Yang, Jiang-Nan Wu, Feng Xie, Tao Zhang, Ming-Qing Li
Summary: This study aimed to identify differentially expressed genes (DEGs) in the endometrium between recurrent implantation failure (RIF) patients and healthy controls based on immune cell infiltration characteristics. The findings revealed six immune-related hub genes involved in Wnt/-β-catenin and Notch signaling pathways. Three of the identified genes (AKT1, PSMB8, and PSMD10) showed potential diagnostic values for RIF. Furthermore, potential therapeutic or induced compounds for RIF were identified through cMap analysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Reproductive Biology
Ya Sun, Xin-Cheng Zhang, Meng-Die Li, Li-Ge Bu, Bo Wang, Ting-Yue Li, Nai-Zheng Ding, Hua Ni
Summary: N-6-methyladenosine (m6A), an epigenetic modification, increases in goat uterus during early pregnancy and is regulated by METTL3. METTL3 positively regulates CTGF expression, which affects the proliferation of endometrial epithelial cells (EECs). These findings provide a foundation for further understanding the crucial role of METTL3-mediated m6A modification in goat uterus during early pregnancy.
BIOLOGY OF REPRODUCTION
(2023)
Article
Chemistry, Physical
Zuxing Zhang, Liying Zhai, Mingqing Li, Jiahui Wu, Li Li
Summary: The RGO/BiVO4 nanocomposites loaded on tetracycline hydrochloride (TCH) photo-electrochemical (PEC) monitoring platform exhibited higher PEC activity due to accelerated electron transfer induced by RGO loading. The RGO/BiVO4 electrode showed a linear response in the concentration range of 0.1 μM - 1 mM with a sensitivity of 45 μA mM cm-2 and a detection limit of 0.922 μM. Furthermore, the designed RGO/BiVO4 PEC sensor demonstrated good reproducibility, long-term stability, and selectivity.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Mingqing Li, Li Ping Qian, Xinyu Dong, Bin Lin, Yuan Wu, Xiaoniu Yang
Summary: In this paper, we investigate the secure computation offloading in the Marine Internet of Things (M-IoT) with the assistance of unmanned surface vehicles (USVs) subject to the eavesdropping attack. We optimize the USVs' positions, the duration of data uploading, the workload offloaded by the high altitude platform (HAP), the HAP's transmission power, and the USVs' jamming signal power to minimize the system-wise energy consumption for completing the total workloads under the latency constraint. Our proposed algorithms, PAS-Algorithm and CASE-Algorithm, effectively optimize the variables and provide suboptimal solutions to the joint optimization problem, validating their accuracy and performance compared with benchmark algorithms.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Cell Biology
Yi-kai Lin, Fan Zhang, Wen-jia Lei, Xiao-wen Gan, Meng-die Li, Fan Pan, Wang-sheng Wang, Kang Sun
Summary: SAA1 serves as a trigger of sterile inflammation in the fetal membranes during parturition. It can induce chemotaxis pathways and upregulate a series of chemokines in human amnion fibroblasts, as well as attract various types of mononuclear leukocytes, particularly monocytes and dendritic cells. SAA1 can also induce the expression of genes associated with inflammation and extracellular matrix remodeling in monocytes, macrophages, and dendritic cells.
INFLAMMATION RESEARCH
(2023)
Article
Obstetrics & Gynecology
Rong Xiao-Fan, Li Ming-Qing, Faustino R. Perez-Lopez, Wu Jiang-Nan, Zhang Bin
Summary: During the one-child policy period in China, female offspring was associated with a higher risk of postpartum depression (PPD). However, there is limited knowledge on the association between maternal expectations on fetal gender and the risk of PPD in the context of the new two-child policy implemented in 2016. This hospital-based cohort study found that unexpected fetal gender was associated with an increased risk of PPD among Chinese primiparous women.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Environmental Sciences
Min-Min Tang, Xue-Feng Hou, Jing Sun, Jia-Yi Cheng, You-Peng Deng, Meng-Die Li, Ling Liu, Dong-Xu Hua, Jin Yang, Ya-Lin Jiang, Lin Fu, Hui Zhao
Summary: This study aimed to evaluate the association between blood cesium concentration and lung function alteration in COPD patients and explore the potential role of oxidative stress in this association. The study found a non-linear relationship between blood cesium concentration and lung function in COPD patients, with an increase in blood cesium associated with reductions in FVC and predicted FEV1%. Smoking status exacerbated the pulmonary function reduction caused by cesium. Blood cesium was inversely associated with pulmonary function parameters, while positively related to serum 8-iso-PGF2 alpha. Oxidative stress may play an important role in mediating the effect of cesium exposure on pulmonary function reduction in COPD patients.
ATMOSPHERIC POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shufan Jiang, Huili Yang, Mingqing Li
Summary: Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates various cell biological functions. Macrophages, present in most human tissues, play important roles in both physiology and pathology. The review highlights the significant role of LPA signaling in macrophages and its involvement in diseases such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. The therapeutic strategies targeting LPA are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fan Zhang, Jiang-Wen Lu, Wen-Jia Lei, Meng-Die Li, Fan Pan, Yi-Kai Lin, Wang-Sheng Wang, Kang Sun
Summary: Inflammation of fetal membranes during parturition is accompanied by increased synthesis of prostaglandin E2 (PGE2), despite the presence of anti-inflammatory glucocorticoids. This study investigates the role of 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in promoting PGE2 synthesis in amnion fibroblasts. It is found that cortisol and 15(S)-HETE levels increase in parallel in the amnion during parturition. Cortisol induces the expression of ALOX15/15B and production of 15(S)-HETE in amnion fibroblasts through p300-mediated histone acetylation and interaction with transcription factors CREB and STAT3. These findings suggest that cortisol regeneration in fetal membranes paradoxically enhances PGE2 synthesis in the inflammatory responses of fetal membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Min Chen, Jia-Lu Shi, Zi-Meng Zheng, Zhi Lin, Ming-Qing Li, Jun Shao
Summary: This study investigated the relationship between trophoblast cell autophagy and recurrent spontaneous abortion (RSA), and found that the LPA/LPAR1-NHE1 axis regulates the autophagy of trophoblast cells. Insufficient autophagy and decreased expression of LPAR1 in trophoblast cells may lead to trophoblast dysfunction and an increased risk of spontaneous abortion.
Article
Biochemistry & Molecular Biology
Liyuan Cui, Minfeng Shi, Xinhang Meng, Jinfeng Qian, Songcun Wang
Summary: This study explores the role of circRNAs in recurrent pregnancy loss (RPL) and their potential regulatory mechanisms, particularly focusing on the regulation of m6A modification. The results show that differentially expressed circRNAs are involved in immune activities, metabolism, and signaling pathways. The competitive endogenous RNA (ceRNA) network analysis reveals the potential role of circRNAs in RPL occurrence, and the expression profiles of m6A regulators are also investigated. Additionally, the expression profiles of circRNAs in the serum are explored as a potential biomarker for the diagnosis of RPL.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
