Article
Chemistry, Multidisciplinary
Ronit Shusterman-Krush, Nishanth D. Tirukoti, Anil Kumar Bandela, Liat Avram, Hyla Allouche-Arnon, Xiaoyang Cai, Bruce C. Gibb, Amnon Bar-Shir
Summary: By applying the principles of CEST-MRI to F-19-MRI, researchers achieved a 900-fold signal amplification for a biocompatible fluorinated agent and demonstrated the potential for using an inhalable fluorinated anesthetic as a single F-19 probe to detect two targets simultaneously in host-guest supramolecular assemblies. Further advancements in this approach could expand the applicability of F-19-MRI to previously undetectable targets.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
KowsalyaDevi Pavuluri, Ethan Yang, Vinay Ayyappan, Kanchan Sonkar, Zheqiong Tan, Caitlin M. Tressler, Shaowei Bo, Adnan Bibic, Kristine Glunde, Michael T. McMahon
Summary: This study evaluated the feasibility of using aspirin as a CEST MRI contrast agent for breast tumor detection. The results showed that aspirin can be converted into salicylic acid for tumor detection. The CEST MRI contrast was found to be independent of COX-1/-2 expression levels.
Article
Chemistry, Multidisciplinary
Subhayan Chakraborty, S. Peruncheralathan, Arindam Ghosh
Summary: Paracetamol and other acetanilide derivatives are reported as a special class of diamagnetic Chemical Exchange Saturation Transfer (diaCEST) MRI contrast agents, showing contrast only when molecules form inter-molecular hydrogen bonding. The contrast drops quickly when the hydrogen bond network breaks and high exchange returns. Paracetamol demonstrates 12% contrast at physiological conditions and shows promise as a diaCEST agent for in vivo studies.
Article
Chemistry, Analytical
Eduardo M. Paiva, Florian M. Schmidt
Summary: Mid-infrared photothermal microscopy is a valuable tool for chemical imaging with high spatial resolution. This study introduces a widefield mid-infrared photothermal heterodyne imaging technique using a digital frequency-domain lock-in filter for simultaneous multiharmonic demodulation of MIP signals. The technique achieves high sensitivity, spatial resolution, and speed. It has the potential to be used for real-time chemical imaging in biology, medicine, and material science.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Zelong Chen, Zheng Han, Guanshu Liu
Summary: CEST MRI is an attractive approach that allows for the direct use of low-concentration, exchangeable proton-containing agents to generate MRI contrast, helping to rapidly translate newly developed MRI agents into clinical use. The ability to utilize diamagnetic compounds has been widely applied to detect clinical compounds, including FDA-approved drugs and X-ray/CT contrast agents.
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemical Research Methods
Daniel Schache, Solene Bardin, Luisa Ciobanu, Cornelius Faber, Verena Hoerr
Summary: We implemented a fast magnetic resonance technique based on chemical exchange saturation transfer (CEST) line scanning to measure the mutarotation kinetics of sugars. The technique allows for ultrafast data acquisition and provides accurate results comparable to conventional measurement methods.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ayesha Bharadwaj Das, James Andrew Tranos, Jin Zhang, Youssef Zaim Wadghiri, Sungheon Gene Kim
Summary: The feasibility of using 2 flip angles during DCE-MRI scan to estimate plasma Gd concentration without using precontrast T1 measurement was investigated. The results showed that using 2 flip angles for T1 estimation is a viable method for estimating plasma Gd concentration during DCE-MRI scan without the need for a separate precontrast T1 measurement.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chathuri J. Kombala, Sanjaya D. Lokugama, Aikaterini Kotrotsou, Tianzhe Li, Alyssa C. Pollard, Mark D. Pagel
Summary: A newly developed CEST agent can simultaneously measure pH and evaluate protease activity, with the ability to determine pH values through selective saturation signals and ratio analysis.
Article
Chemistry, Medicinal
Ilse M. Welleman, Friederike Reessing, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Ben L. Feringa, Wiktor Szymanski
Summary: Molecular imaging of biomarkers, especially enzyme activity, is a promising approach in medical diagnostics. In this study, molecular imaging agents were developed and evaluated for the detection of sulfatase activity using MRI and CEST imaging. The results provide a proof-of-principle for magnetic imaging of cancer biomarkers and highlight the potential clinical applications of this approach.
Review
Radiology, Nuclear Medicine & Medical Imaging
Faraz Ahmad, Lee Treanor, Trevor A. McGrath, Daniel Walker, Matthew D. F. McInnes, Nicola Schieda
Summary: The study found that the adverse event rate of ferumoxytol as an MRI contrast agent is 2%, with a mix of mild, moderate, and severe adverse events reported. There were no deaths related to ferumoxytol administration, but the safety of ferumoxytol as an alternative to gadolinium-based contrast agents in patients with prior hypersensitivity reactions remains unexplored.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Chemistry, Analytical
Longhui Zhao, Qianni Guo, Chenlu Yuan, Sha Li, Yaping Yuan, Qingbin Zeng, Xu Zhang, Chaohui Ye, Xin Zhou
Summary: Riboflavin and its derivatives are essential coenzymes in vivo metabolism, and a novel photolysis Xe-129 biosensor was successfully developed by combining cryptophane-A with riboflavin moiety. The biosensor showed photosensitivity with a significant chemical shift change of 5.3 ppm in aqueous solution, and demonstrated potential application in tumor targeting and inhibition of tumor cell proliferation after photodegradation.
Article
Chemistry, Medicinal
Martin Kunth, Christopher Witte, Leif Schroeder
Summary: Xenon magnetic resonance imaging (MRI) offers excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST), with molecular hosts like cryptophane-A or cucurbit[n]urils providing opportunities for switchable MRI reporters. Utilizing an internal reference host to resolve exchange kinetics information allows quantitative comparisons of different ultra-sensitive MRI reporters.
Article
Biophysics
Sebastian Mueller, Klaus Scheffler, Moritz Zaiss
Summary: CEST MRI has the potential to detect low-concentration molecules and proteins, with substances like agar potentially affecting CEST effects, necessitating consideration of their contributions to ensure accurate experimental results.
NMR IN BIOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Physical
Konstantin Romanenko, Philip W. Kuchel, Alexej Jerschow
CHEMISTRY OF MATERIALS
(2020)
Article
Biochemical Research Methods
KowsalyaDevi Pavuluri, Jens T. Rosenberg, Shannon Helsper, Shaowei Bo, Michael T. McMahon
JOURNAL OF MAGNETIC RESONANCE
(2020)
Article
Multidisciplinary Sciences
Yinan Hu, Geoffrey Z. Iwata, Mohaddese Mohammad, Emilia V. Silletta, Arne Wickenbrock, John W. Blanchard, Dmitry Budker, Alexej Jerschow
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Or Perlman, Hirotaka Ito, Assaf A. Gilad, Michael T. McMahon, E. Antonio Chiocca, Hiroshi Nakashima, Christian T. Farrar
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Xue Zhang, Georgios Chatzidrosos, Yinan Hu, Huijie Zheng, Arne Wickenbrock, Alexej Jerschow, Dmitry Budker
Summary: Sensitive and accurate diagnostic technologies with magnetic sensors are crucial for identifying and localizing defects in rechargeable solid batteries. A microwave-free AC magnetometry method using negatively charged NV centers in diamond was developed, enabling non-destructive imaging of solid-state batteries and detection of structural anomalies with high spatial resolution. The technique detected eddy-current-induced magnetic fields, distinguishing defects on external electrodes and identifying anomalies within battery bodies.
APPLIED SCIENCES-BASEL
(2021)
Correction
Chemistry, Physical
Konstantin Romanenko, Philip W. Kuchel, Alexej Jerschow
CHEMISTRY OF MATERIALS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Stabinska, Aruna Singh, Nora M. Haney, Yuguo Li, Farzad Sedaghat, Max Kates, Michael T. McMahon
Summary: This study investigates the potential of DCE MR CEST urography for assessing renal function in mice with unilateral ureter obstruction (UUO) by simultaneous pH and renal uptake/clearance measurements. The results show that DCE-MR-CEST urography can detect changes in renal uptake/excretion and pH homeostasis and distinguish between obstructed and unobstructed kidney as early as 1 day after UUO.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Iurii Chubak, Leeor Alon, Emilia V. V. Silletta, Guillaume Madelin, Alexej Jerschow, Benjamin Rotenberg
Summary: Nuclear magnetic resonance relaxometry is a powerful tool for extracting dynamic information, but obtaining links to molecular motion is challenging for many ions that relax through the quadrupolar mechanism. In this study, the authors combine ab initio calculations and classical molecular dynamics to obtain relaxation rates in good agreement with experiments for sodium ions in aqueous electrolytes. They demonstrate that quadrupolar nuclear relaxation is sensitive to subpicosecond dynamics not captured by previous models, and the experimental trends are mainly explained by dynamics in the first two solvation shells of sodium, which contain mostly water. This work paves the way to the quantitative understanding of quadrupolar relaxation in electrolyte and bioelectrolyte systems.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Jiaqi Lu, Alexej Jerschow, David E. Korenchan
Summary: This paper introduces spectral editing sequences that selectively attenuate or nullify undesired spin magnetization while preserving the desired signals, simplifying NMR spectra and facilitating single-species imaging applications.
JOURNAL OF MAGNETIC RESONANCE
(2023)
Article
Chemistry, Physical
David E. Korenchan, Jiaqi Lu, Mohamed Sabba, Laurynas Dagys, Lynda J. Brown, Malcolm H. Levitt, Alexej Jerschow
Summary: Nuclear spin relaxation mechanisms are challenging to identify, especially in flexible molecules. This study combines experimental and computational approaches to determine the major mechanisms responsible for spin-lattice and singlet order relaxation in pyrophosphate. Chemical shift anisotropy and spin-rotation were identified as the major mechanisms, with minor contributions from intra- and intermolecular coupling.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Boris Kharkov, Xueyou Duan, Jyrki Rantaharju, Mohamed Sabba, Malcolm H. Levitt, James W. Canary, Alexej Jerschow
Summary: This study investigates the lifetime of nuclear spin singlet states and factors affecting its longevity through experimental and computational methods. The results demonstrate that molecular dynamics simulations can accurately account for the observed lifetime without adjustable parameters. The study highlights the significance of considering unusual and difficult-to-control mechanisms as limiting factors for nuclear spin singlet lifetimes and emphasizes the power of molecular dynamics simulations in understanding unknown NMR relaxation mechanisms.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Konstantin Romanenko, Alexej Jerschow
Summary: As the demand for batteries grows, new screening methods are crucial in preventing catastrophic failures. Surface-scan MRI is a non-destructive technique that accurately detects electrode degradation and hazardous states during the charging process.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Physical
David E. Korenchan, Jiaqi Lu, Malcolm H. Levitt, Alexej Jerschow
Summary: The study focused on P-31 NMR spectroscopy and the relaxation of nuclear spin singlet phenomena, highlighting the importance of phosphorus-containing compounds in physiology. The experiment demonstrated the relaxation of P-31 singlet order in cases of chemical equivalence but magnetic inequivalence, with the mechanism of singlet state population conversion explained by couplings between H-1 and P-31 nuclei. Molecular dynamics simulations and ab initio calculations provided excellent agreement with the experimental findings, suggesting potential guidance for future studies on P-31 singlets in other compounds, including biomolecules.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Electrochemistry
Roberta Pigliapochi, Stefan Benders, Emilia Silletta, Stephen L. Glazier, Elizabeth Lee, Jeff Dahn, Alexej Jerschow
Summary: Rechargeable battery cells are difficult to analyze using traditional imaging methods, which can be sensitive to background gradients. A new approach based on free induction decays has been proposed to quickly and accurately extract internal properties of batteries, providing strong classification power for cathode materials.
BATTERIES & SUPERCAPS
(2021)
Article
Chemistry, Physical
Christian Bengs, Mohamed Sabba, Alexej Jerschow, Malcolm H. Levitt
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
