Review
Biochemistry & Molecular Biology
Nan Nan, Wanhe Hu, Jingxin Wang
Summary: Lignin-based porous biomaterials have strong potential applications in medicine, such as drug delivery, tissue engineering, and wound dressing. The addition of lignin can modify the materials' properties, while the size, shape, and distribution of pores determine the materials' porous structure and adsorption ability.
Article
Chemistry, Multidisciplinary
Alma Martin, Jenny Natalie Nyman, Rikke Reinholdt, Jun Cai, Anna-Lena Schaedel, Mariena J. A. van der Plas, Martin Malmsten, Thomas Rades, Andrea Heinz
Summary: Nanofiber-reinforced hydrogels have attracted attention in biomedical engineering due to their mechanical strength, water absorption properties, and potential for promoting cell migration. This study demonstrates a one-step solution for producing nanofiber-reinforced hydrogels using zein and gelatin proteins. The resulting nanofiber-hydrogel composite showed significant improvements in swelling and physical integrity compared to hydrogels without nanofibers. Additionally, the incorporation of antimicrobial agents into the fibers proved effective against Staphylococcus aureus and Escherichia coli.
Review
Biochemistry & Molecular Biology
Sakshi Priya, Unnati Batra, B. N. Samshritha, Sudhanshu Sharma, Akash Chaurasiya, Gautam Singhvi
Summary: Nanofibers are fibrous nanocarriers that can be synthesized from various materials, including natural polymers. Natural polysaccharides-based nanofibers have gained attention in pharmaceutical and biomedical applications due to their biocompatibility, biodegradability, non-toxicity, and economic advantages. However, there is a lack of research on the scale-up and advanced therapeutic delivery of nanofibers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Anabela Moreira, Dan Lawson, Lesley Onyekuru, Karolina Dziemidowicz, Ukrit Angkawinitwong, Pedro F. Costa, Norbert Radacsi, Gareth R. Williams
Summary: This review explores the potential of electrohydrodynamic (EHD) techniques in developing peptide and protein delivery systems, discussing the principles of various EHD methods and encapsulation of biological molecules using these approaches, as well as exploring the possibilities of localized delivery with stimuli-responsive systems and summarizing the advantages and challenges of electrospun and electrosprayed protein delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Andrea Luraghi, Francesco Peri, Lorenzo Moroni
Summary: Drug delivery devices are promising in maximizing therapeutic effects and minimizing undesired side effects. Electrospun nanofibers have unique features like biocompatibility and flexibility, making them efficient in delivering active principles for a wide range of drugs. The technique of electrospinning allows for easy tuning and endless combinations, potentially leading to personalized medicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Mohammadreza Rostami, Nima Beheshtizadeh, Faezeh Esmaeili Ranjbar, Nahid Najafi, Azam Ahmadi, Parisa Ahmadi, Hadis Rostamabadi, Zahra Pazhouhnia, Elham Assadpour, Mina Mirzanajafi-Zanjani, Misagh Fathi Kisomi, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Electrospinning is a convenient, adaptive, and scalable technique for manufacturing nano/micro/macro-fibers. Protein-based electrospun fibers have desirable properties such as biocompatibility, low toxicity, degradability, and solvolysis. This paper provides an overview of protein-based biomaterials and their potential for electrospinning. It also showcases the applications of electrospun protein fibers in the food and biomedical industries and discusses the future prospects and challenges they present.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xiaowen Han, Mingda Zhao, Ruiling Xu, Yaping Zou, Yuxiang Wang, Jie Liang, Qing Jiang, Yong Sun, Yujiang Fan, Xingdong Zhang
Summary: Synchronous control of disease and regeneration progression is necessary for lesioned tissue after surgery, and therapeutic and regenerative scaffolds need to be developed. Electrospun hyaluronic acid derivative nanofiber membranes can promote the potential regeneration of injured skin tissues and achieve therapeutic effects when incorporated with drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Materials Science, Multidisciplinary
Miaomiao Zhang, Shixin Xu, Ruoying Wang, Yongan Che, Cuicui Han, Wei Feng, Chengwei Wang, Wen Zhao
Summary: Electrospun nanofiber/hydrogel composites have gained significant attention due to their combination of excellent biochemical properties of hydrogel with the biomimetic nature of electrospun fibers. These composites, with tunable mechanical properties, can mimic the microstructure of extracellular matrix (ECM) and microenvironment of cells, making them advantageous for tissue repair. However, a comprehensive review on their application as tissue engineering scaffolds is lacking. This article systematically reviews the preparation and application of electrospun fiber/hydrogel composites in tissue engineering, providing insights for future research directions.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Raul Cazorla-Luna, Roberto Ruiz-Caro, Maria-Dolores Veiga, R. Karl Malcolm, Dimitrios A. Lamprou
Summary: Electrospinning is a cutting-edge technology for producing nanofibers and microfibers by applying high voltage to polymer solutions or melts, with potential applications in drug delivery systems and tissue engineering. Recent years have witnessed a growing interest in utilizing electrospinning technology for the treatment and prevention of diseases related to women's sexual and reproductive health.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Pariya Zare, Mohamad Pezeshki-Modaress, Seyed Mohammad Davachi, Pouria Zare, Fatemeh Yazdian, Sara Simorgh, Hadi Ghanbari, Hamid Rashedi, Zohreh Bagher
Summary: In this study, two different arrangements of laminated composite scaffolds were fabricated based on Alginate, showcasing improved mechanical features and sustained drug release. The optimized scaffold displayed advantages such as interconnected pores, controlled biodegradability, and no cytotoxic effect, making it a promising candidate for tissue regeneration.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Saeed Farzamfar, Elissa Elia, Stephane Chabaud, Mohammad Naji, Stephane Bolduc
Summary: Electrospun scaffolds show great potential in urethral defect repair by mimicking native cells' niches and delivering drugs and cells, but there are still challenges and issues to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Renatha Jiffrin, Saiful Izwan Abd Razak, Mohamad Ikhwan Jamaludin, Amir Syahir Amir Hamzah, Muadz Ahmad Mazian, Muhammad Azan Tamar Jaya, Mohammed Z. Nasrullah, Mohammed Majrashi, Abdulrahman Theyab, Ahmed A. Aldarmahi, Zuhier Awan, Mohamed M. Abdel-Daim, Abul Kalam Azad
Summary: Electrospinning is a promising method for creating nanofiber membranes that can release drugs over time. These nanofiber composites have a large surface area to volume ratio, which aids in cell binding, drug loading, and mass transfer processes.
Article
Engineering, Biomedical
Fatemeh Mokhtari, Bahareh Azimi, Maryam Salehi, Samaneh Hashemikia, Serena Danti
Summary: Organic piezoelectric biomaterials, especially PVDF-based polymers, have gained significant attention in biomedical devices for their ability to convert physiological movements into electrical signals. These materials show promising applications in controlled drug delivery systems, tissue engineering, microfluidics, and artificial muscle actuators.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Egemen Uzel, Meltem Ezgi Durgun, Imren Esenturk-Guzel, Sevgi Gungor, Yildiz Ozsoy
Summary: Nanofibers are highly versatile modern materials with wide-ranging applications in daily life. Their production techniques, which are easy, cost effective, and easily scalable, contribute to their popularity. Nanofibers are preferred in the field of healthcare for drug delivery systems and tissue engineering, and they are also frequently used in ocular applications due to their biocompatible materials. The long drug release time and successful applications in corneal tissue engineering are important advantages of nanofibers.
Article
Engineering, Biomedical
Ying Liu, Yunen Liu, Mi Wu, Rufei Zou, Shun Mao, Peifang Cong, Mingxiao Hou, Hongxu Jin, Yan Zhao, Yongli Bao
Summary: β-ChNF, prepared from squid pens, showed promising effects on wound healing and promotion of cell secretions through cell loading experiments.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Engineering, Chemical
Pratikshkumar R. Patel, Komal Pandey, Naresh Killi, Rathna Venkata Naga Gundloori
Summary: A hybrid system of PLA and PCL, incorporating EA, was designed to improve cell interactions. The addition of EA increased the swelling rate of NM and decreased contact angle. Moreover, EA enhanced the inhibition of bacterial growth by NM.
POLYMER ENGINEERING AND SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Pratikshkumar R. Patel, Amarnath Singam, Arun Dadwal, Rathna Venkata Naga Gundloori
Summary: Stearic acid-coated magnetic nanoparticles (SMN) were immobilized in neem oil-based polyesteramide and fabricated as nanofiber mats (NM) for controlled release of 5-Fluorouracil (FU) under an external magnetic field. In vitro studies showed significant difference in cumulative release of FU between SMN-NMs and NMs, with SMN-NMs releasing 95% of FU in 4 hours and NMs releasing 83% in 24 hours. The developed SMN-NFs exhibited potential for targeted drug delivery in cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Neha Kulkarni-Dwivedi, Pratikshkumar R. Patel, Bhupendra Shravage, Rinku D. Umrani, Kishore M. Paknikar, Sachin H. Jadhav
Summary: This study demonstrates that the use of folic acid-conjugated lanthanum strontium manganese oxide nanoparticles (Fol-LSMO NPs) in hyperthermia and chemotherapy can induce apoptosis and autophagy in breast cancer cells, resulting in effective anticancer activity.
Article
Chemistry, Multidisciplinary
Amarnath Singam, Naresh Killi, Pratikshkumar R. Patel, Rathna V. N. Gundloori
Summary: Natural polymers offer advantages over synthetic polymers in drug delivery systems due to their renewability, biocompatibility, and low immunogenicity. In this study, a new micellar DDS using ethyl cellulose grafted with polyethylene glycol was synthesized and characterized, showing promising properties and drug release kinetics for potential cancer treatment applications.
Article
Polymer Science
Zhongming Yuan, Hiroko Yamamoto, Shinji Kanehashi, Takeshi Shimomura
Summary: This study reports the synthesis of a flexible light-emitting polymer film using a solution blending method. The selective positioning of MEH-PPV molecules in the PS phase of the film was confirmed. The film exhibited a nanometer-scale luminescent domain with low aggregation quenching and showed good elastomeric characteristics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2024)
