Review
Cell Biology
Zhenyu Zhai, Pengtao Zou, Fuxiang Liu, Zirong Xia, Juxiang Li
Summary: Ferroptosis, a recently discovered iron-dependent programmed cell death pathway, plays a significant role in cardiovascular diseases. Research has shown that blocking the ferroptosis pathways can alleviate myocardial injury. Therefore, ferroptosis may be a novel diagnostic and therapeutic target for patients suffering from cardiomyopathy in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medical Laboratory Technology
Giuseppe Pinto, Barbara Colombo, Adriano Autieri, Luca Foppoli, Roberto Spoladore, Valentina Ardizzone, Alberto Margonato, Angelo Corti, Gabriele Fragasso
Summary: In patients with chronic systolic heart failure, vasostatin-1 and chromogranin A may serve as prognostic markers for cardiovascular events, providing complementary information to NT-proBNP and age, distinct from the association with left ventricular ejection fraction.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Lara Aguilar-Iglesias, Ana Merino-Merino, Ester Sanchez-Corral, Maria-Jesus Garcia-Sanchez, Isabel Santos-Sanchez, Ruth Saez-Maleta, Jose-Angel Perez-Rivera
Summary: This study aims to compare the diagnostic performance of cardiac biomarkers in predicting frailty in different age groups. The results show that in the younger group, frailty is primarily determined by age and comorbidities, while in the elderly group, NT-proBNP is significantly associated with frailty. Adding NT-proBNP can improve the detection of frailty in elderly patients with acute heart failure.
Article
Medicine, Research & Experimental
Lu Qian, Qian Zhao, Ping Yu, Jinhui Lu, Yuefan Guo, Xin Gong, Yuanyuan Ding, Shanshan Yu, Lieying Fan, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Hongzhuan Sheng, Zuoren Yu
Summary: Heart failure is a leading cause of death worldwide, and its incidence is increasing due to the aging population. In this study, circulating miRNAs were analyzed to identify diagnostic biomarkers for heart failure. Two miRNAs, miR-30a-5p and miR-654-5p, were found to be significantly changed in the plasma of heart failure patients. A two-circulating miRNA model was developed for diagnosis and prognosis of heart failure, which showed promising potential in an independent validation cohort.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Su, Yuxi Sun, Yansong Tang, Hao Li, Xiaoyu Wang, Xin Pan, Weijing Liu, Xianling Zhang, Fenglei Zhang, Yawei Xu, Chunxi Yan, Sang-Bing Ong, Dachun Xu
Summary: The study identified miR-19b-3p as a valuable prognostic biomarker for AHF patients, indicating ventricular hypertrophy and correlating with echocardiographic indexes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Junlei Li, Chao Jiang, Yiwei Lai, Li Li, Xiaoyan Zhao, Xiaofang Wang, Ling Li, Xin Du, Changsheng Ma, Jianzeng Dong
Summary: This study aimed to investigate the association of on-admission anemia with 1-year mortality in patients hospitalized with acute heart failure. The results showed that on-admission anemia, defined by WHO criteria, is not an independent predictor of mortality in these patients. However, moderate-to-severe anemia was found to be independently associated with increased mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Yifei Tao, Wenjing Wang, Jing Zhu, Tao You, Yi Li, Xiang Zhou
Summary: The study identified obesity, age, antihypertensive medications, echocardiographic results, and pulmonary artery pressure as independent predictors of 1-year readmission for HFpEF patients. The H2FPEF score demonstrated excellent predictive value for 1-year rehospitalisation of patients with HFpEF.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Physiology
Marta Reina-Couto, Carolina Silva-Pereira, Patricia Pereira-Terra, Janete Quelhas-Santos, Joao Bessa, Paula Serrao, Joana Afonso, Sandra Martins, Claudia Camila Dias, Manuela Morato, Joao T. Guimaraes, Roberto Roncon-Albuquerque, Jose-Artur Paiva, Antonio Albino-Teixeira, Teresa Sousa
Summary: Inflammation-driven endothelitis plays a significant role in acute heart failure and cardiogenic shock. This study evaluated the levels of endocan in patients with these conditions and correlated them with markers of inflammation, endothelial activation, cardiovascular dysfunction, and prognosis. The findings suggest that endocan may be a biomarker for endothelitis and a potential therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Masaki Izumo
Summary: Echocardiography plays a crucial role in understanding cardiac function and hemodynamics in patients with acute HF, despite being highly recommended by guidelines but with limited evidence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Camron Edrissi, Chase Rathfoot, Krista Knisely, Carolyn Breauna Sanders, Richard Goodwin, Samuel I. Nathaniel, Thomas Nathaniel
Summary: This study analyzed the severity and risk factors of acute ischemic stroke (AIS) in patients with heart failure (HF). The study found several risk factors associated with higher stroke severity in patients aged 65-74 and >=75. Understanding the risk factors associated with stroke severity in HF patients is important for predicting and preventing the severity of stroke.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Radu-Stefan Miftode, Irina-Iuliana Costache, Daniela Constantinescu, Ovidiu Mitu, Amalia-Stefana Timpau, Monica Hancianu, Daniela-Anicuta Leca, Ionela-Larisa Miftode, Raul-Alexandru Jigoranu, Alexandru-Florinel Oancea, Mihai Stefan Cristian Haba, Diandra Ioana Miftode, Ionela-Lacramioara Serban
Summary: Acute heart failure (HF) is a complex clinical syndrome associated with high mortality and systemic complications. Natriuretic peptides (e.g., NT-proBNP) are currently used as the gold standard for diagnosis and prognosis in acute HF, but they do not accurately reflect all pathophysiological mechanisms. Therefore, there is a growing interest in using a multi-marker approach for risk stratification. Syndecan-1, a less studied biomarker in cardiovascular diseases, shows promise in reflecting myocardial pathological changes and predicting organ dysfunction.
Article
Biochemistry & Molecular Biology
Michael Chhor, Hao Chen, Djurdja Jerotic, Milorad Tesic, Valentina N. N. Nikolic, Milan Pavlovic, Rada M. M. Vucic, Benjamin Rayner, Chris J. J. Watson, Mark Ledwidge, Kenneth McDonald, Tracy Robson, Kristine C. C. McGrath, Lana McClements
Summary: Heart failure (HF) is a major cause of hospitalizations worldwide, with a low survival rate within 5 years after diagnosis. The role of FKBPL in HFpEF pathogenesis and as a biomarker was investigated in in vitro cardiac hypertrophy models and human plasma samples. The results suggest that FKBPL may have therapeutic potential in HFpEF but is unable to differentiate between different forms of HFpEF.
Review
Pharmacology & Pharmacy
Kaizu Xu, Chungui Chen, Ying Wu, Meifang Wu, Liming Lin
Summary: The microRNA-132 (miR-132), widely expressed in the cardiovascular system, is a potential diagnostic and therapeutic biomarker for cardiovascular diseases; it has been shown to be a master regulator in the pathological processes of ischemic or nonischemic heart failure in the myocardium.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
P. Christian Schulze, Juergen Bogoviku, Julian Westphal, Pawel Aftanski, Franz Haertel, Sissy Grund, Stephan von Haehling, Ulrike Schumacher, Sven Moebius-Winkler, Martin Busch
Summary: This study suggests that early addition of empagliflozin to standard diuretic therapy can increase urine output in patients with acute decompensated heart failure without affecting renal function.
Article
Cardiac & Cardiovascular Systems
Jing Jiang, Baojun Yang, Ying Sun, Jing Jin, Zhiying Zhao, Songming Chen
Summary: This study demonstrates that galectin-3 has a moderate diagnostic value for heart failure with preserved ejection fraction. The concentration of galectin-3 is significantly higher in patients with heart failure compared to those without. Galectin-3 is an independent predictor of heart failure with preserved ejection fraction and its diagnostic value is higher than that of other parameters.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Virology
Alireza Ala, Solomon Habtemariam, Samad Shams Vandati, Aysa Rezabakhsh
Summary: In addition to the common symptoms, identifying the extraordinary manifestations of COVID-19 is important for clinical management. This report presents two cases with reactive lymphadenopathies and a herpes-like skin lesion, without symptoms of lower respiratory tract infection.
Review
Cell Biology
Aysa Rezabakhsh, Seyyed-Reza Sadat-Ebrahimi, Alireza Ala, Seyed Mohammad Nabavi, Maciej Banach, Samad Ghaffari
Summary: This review article discusses the dynamic changes of common laboratory parameters during COVID-19 and their association with cardiovascular diseases, as well as monitoring early stage indicators and recovery processes. It also examines the time required for biomarkers to return to basal levels and addresses the latest updates on cardiovascular biomarkers as prognostic and diagnostic criteria for the severity of COVID-19.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Neurosciences
Aysa Rezabakhsh, Nafiseh Vahed, Hossein Hosseinifard, Reza Rahbarghazi, Fatemeh Salehnia, Yalda Sadeghpour, Sarvin Sanaie
Summary: Autophagy modulation is considered a potential therapeutic target for managing ischemic stroke. The activation time of autophagy after injury strongly influences its pros and cons. This systematic review aims to explore the impact of pharmacological autophagy modulation on infarct size in experimental stroke models.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Mahdi Abdoli-Shadbad, Alireza Alihemmati, Aniseh Javadi, Reza Badalzadeh
Summary: Pretreatment with LA in diabetic rats restored cardioprotection by IPostC via modulating autophagy and restoring mitochondrial function. This combined conditioning strategy may effectively reduce I/R damage in diabetic hearts.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Infectious Diseases
Behnaz Mokhtari, Rana Yavari, Reza Badalzadeh, Ata Mahmoodpoor
Summary: Sepsis is a life-threatening organ failure caused by the host's dysregulated response to infection. Myocardial dysfunction, a well-known manifestation of sepsis, is associated with worse outcomes. Mitochondrial damage plays a crucial role in sepsis-related myocardial dysfunction, but effective treatment modalities are currently lacking.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmad Jamei Khosroshahi, Behnaz Mokhtari, Reza Badalzadeh
Summary: This study investigated the ameliorative impact of combination therapy with nicotinamide mononucleotide (NMN) and troxerutin (TXR) on doxorubicin (DOX)-induced cardiotoxicity. The results showed that this combination therapy could reduce cardiac histopathological damages, restore mitochondrial function/biogenesis, and decrease inflammatory response.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Seyed Fazel Nabavi, Adeleh Sahebnasagh, Ahad Shahbazi, Seyed Mohammad Nabavi, Saeid Azimi, Malihe Khayat Kashani, Solomon Habtemariam, Mojde Rahmani, Mohadese Badiee, Javad Hashemi, Fatemeh Saghafi, Kiumarth Amini, Mina Azimi, Aysa Rezabakhsh
Summary: Given the significance of COVID-19-induced ARDS, researchers have recently focused on identifying the underlying mechanisms of inflammatory responses. Inflammasomes play a crucial role in cytokine storm development and subsequent ARDS progression in patients with SARS-CoV-2 infection. This mini-review provides a comprehensive analysis of known inflammasome inhibitors and ongoing research in this field.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh
Summary: The role of autophagy in myocardial ischemia/reperfusion injury is controversial, as it can both promote cell survival and lead to cell death. Understanding the exact role of autophagy in determining the fate of cardiomyocytes is crucial for future cardioprotective strategies.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Masoud Hamidi, Reza Badalzadeh, Ata Mahmoodpoor
Summary: This study assessed the effect of mitochondrial transplantation on sepsis-induced myocardial dysfunction in a rat model. Mitotherapy significantly improved 72-hours survival, decreased LDH and cTn-I levels, restored mitochondrial function and gene expression, and suppressed inflammatory response. Mitotherapy offers a promising strategy to overcome life-threatening sepsis challenge.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Poul Flemming Hoilund-Carlsen, Leila Chodari, Masoud Yasami, Reza Badalzadeh, Samad Ghaffari
Summary: The study found that aging and diabetes cause loss of cardioprotection against myocardial ischemia/reperfusion injury. However, administration of a mitochondrial cocktail (melatonin/nicotinamide mononucleotide/ubiquinol) significantly improved myocardial I/R injury and restored mitochondrial function and biogenesis through regulation of mitochondrial biogenesis gene expression.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh
Summary: This study investigates the interaction between aging and cardioprotection induced by combination therapy with coenzyme Q(10) (CoQ(10)) and mitochondrial transplantation in myocardial ischemia/reperfusion (I/R) injury of aged rats. The results show that the combination of CoQ(10) and mitochondrial transplantation attenuates myocardial I/R injury in aged rats by modulating autophagy and inflammatory response, thereby restoring the aging-related loss of cardioprotection in aged patients.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Behnaz Mokhtari, Leila Hosseini, Poul Flemming Hoilund-Carlsen, Raheleh Salehinasab, Mojgan Rajabi, Reza Badalzadeh
Summary: Prognosis of myocardial ischemia/reperfusion (I/R) injury is poor in elderly patients. Combination therapy of NMN/melatonin can effectively protect the aged rat heart from myocardial I/R injury through modulation of mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sanaz Gholami, Reza Badalzadeh, Alireza Alihemmati
Summary: This study evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-II diabetes following ischemia/reperfusion injury. The results showed that the concomitant use of ALA and Post significantly reduced apoptosis and improved cardiac recovery after heart injury in diabetic conditions.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohammad Ghader Bayazidi, Reza Rahbarghazi, Aysa Rezabakhsh, Jafar Rezaie, Mehdi Hassanpour, Mahdi Ahmadi
Summary: This study investigated the impact of type 2 diabetes mellitus on autophagy status in rat pulmonary tissue. The results showed that diabetes led to pathological changes in the lungs, accompanied by increased levels of TNF-alpha and TGF-beta. It also disrupted the oxidative status and inhibited the normal activity of autophagy flux.