Epitranscriptomic mRNA modifications governing plant stress responses: underlying mechanism and potential application

Global N6-Methyladenosine Profiling Revealed the Tissue-Specific Epitranscriptomic Regulation of Rice Responses to Salt Stress

(2022) Yinxiao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide sequence identification and expression analysis of N6-methyladenosine demethylase in sugar beet (Beta vulgaris L.) under salt stress

(2022) Jie Cui et al.   PeerJ

FIONA1‐Mediated m 6 A Modification Regulates the Floral Transition in Arabidopsis

(2022) Tao Xu et al.   Advanced Science

ALKBH8B, a Putative RNA Demethylase, Plays a Role in the Response of Arabidopsis to Salt Stress and Abscisic Acid

(2022) Trinh Thi Huong et al.   JOURNAL OF PLANT BIOLOGY

MdMTA‐mediated m 6 A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress

(2022) Nan Hou et al.   NEW PHYTOLOGIST

Genome engineering for crop improvement and future agriculture

(2021) Caixia Gao   CELL

Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases

(2021) Emma Wilkinson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptome-wide analysis of epitranscriptome and translational efficiency associated with heterosis in maize

(2021) Jin-Hong Luo et al.   JOURNAL OF EXPERIMENTAL BOTANY

Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies

(2021) Peizhe Song et al.   Molecular Plant

CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis

(2021) Yifeng Hou et al.   Molecular Plant

N 6 ‐Methyladenosine mRNA methylation is important for salt stress tolerance in Arabidopsis

(2021) Jianzhong Hu et al.   PLANT JOURNAL

R-loop resolution promotes co-transcriptional chromatin silencing

(2021) Congyao Xu et al.   Nature Communications

OsEDM2L mediates m 6 A of EAT1 transcript for proper alternative splicing and polyadenylation regulating rice tapetal degradation

(2021) Kun Ma et al.   Journal of Integrative Plant Biology

RNA N 6 ‐methyladenosine modification suppresses replication of rice black streaked dwarf virus and is associated with virus persistence in its insect vector

(2021) Shuping Tian et al.   MOLECULAR PLANT PATHOLOGY

Identification of differential RNA modifications from nanopore direct RNA sequencing with xPore

(2021) Ploy N. Pratanwanich et al.   NATURE BIOTECHNOLOGY

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

(2021) Qiong Yu et al.   NATURE BIOTECHNOLOGY

Alpha‐ketoglutarate‐dependent dioxygenase homolog 10B, an N 6 ‐methyladenosine mRNA demethylase, plays a role in salt stress and abscisic acid responses in Arabidopsis thaliana

(2021) Yasira Shoaib et al.   PHYSIOLOGIA PLANTARUM

Coordination of m6A mRNA methylation and gene transcriptome in rice response to cadmium stress

(2021) Qin Cheng et al.   Rice

Transcriptome-Wide N6-Methyladenosine (m6A) Profiling of Susceptible and Resistant Wheat Varieties Reveals the Involvement of Variety-Specific m6A Modification Involved in Virus-Host Interaction Pathways

(2021) Tian-ye Zhang et al.   Frontiers in Microbiology

ALKBH10B, an mRNA m6A Demethylase, Modulates ABA Response During Seed Germination in Arabidopsis

(2021) Jun Tang et al.   Frontiers in Plant Science

N6-Methyladenosine Regulators and Related LncRNAs Are Potential to be Prognostic Markers for Uveal Melanoma and Indicators of Tumor Microenvironment Remodeling

(2021) Zhicheng Liu et al.   Frontiers in Oncology

OseIF3h Regulates Plant Growth and Pollen Development at Translational Level Presumably through Interaction with OsMTA2

(2021) Yuqing Huang et al.   Plants-Basel

Transcriptome-wide N6-methyladenosine (m6A) methylation in watermelon under CGMMV infection

(2021) Yanjun He et al.   BMC PLANT BIOLOGY

N6-methyladenosine modification underlies messenger RNA metabolism and plant development

(2021) Yanlin Shao et al.   CURRENT OPINION IN PLANT BIOLOGY

The m 6 A reader MhYTP2 regulates MdMLO19 mRNA stability and antioxidant genes translation efficiency conferring powdery mildew resistance in apple

(2021) Tianli Guo et al.   PLANT BIOTECHNOLOGY JOURNAL

Unique features of the m6A methylome and its response to drought stress in sea buckthorn (Hippophae rhamnoides Linn.)

(2021) Guoyun Zhang et al.   RNA Biology

The m6A RNA Demethylase ALKBH9B Plays a Critical Role for Vascular Movement of Alfalfa Mosaic Virus in Arabidopsis

(2021) Mireya Martínez-Pérez et al.   Frontiers in Microbiology

Profiling of N6-Methyladenosine (m6A) Modification Landscape in Response to Drought Stress in Apple (Malus prunifolia (Willd.) Borkh)

(2021) Xiushan Mao et al.   Plants-Basel

AtTRM61/AtTRM6 complex is a bona fide tRNA N1-methyladenosine methyltransferase in Arabidopsis

(2020) Jun Tang et al.   JOURNAL OF EXPERIMENTAL BOTANY

H3K36me2 is highly correlated with m 6 A modifications in plants

(2020) Sangrea Shim et al.   Journal of Integrative Plant Biology

Molecular Mechanisms Driving mRNA Degradation by m6A Modification

(2020) Yujin Lee et al.   TRENDS IN GENETICS

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

(2020) Matthew T Parker et al.   eLife

OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature

(2020) Yongyan Tang et al.   DEVELOPMENTAL CELL

MTA, an RNA m6A Methyltransferase, Enhances Drought Tolerance by Regulating the Development of Trichomes and Roots in Poplar

(2020) Liang Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

(2020) Jiexin Li et al.   NUCLEIC ACIDS RESEARCH

The N1-methyladenosine methylome of petunia messenger RNA

(2020) Weiyuan Yang et al.   PLANT PHYSIOLOGY

The protective role of m1A during stress-induced granulation

(2020) Marion Alriquet et al.   Journal of Molecular Cell Biology

Genome-wide identification and expression analysis of YTH domain-containing RNA-binding protein family in common wheat

(2020) Jing Sun et al.   BMC PLANT BIOLOGY

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

(2020) Christopher Wilson et al.   NATURE BIOTECHNOLOGY

N 6 ‐methyladenosine and RNA secondary structure affect transcript stability and protein abundance during systemic salt stress in Arabidopsis

(2020) Marianne C. Kramer et al.   Plant Direct

Long non-coding RNAs: emerging players regulating plant abiotic stress response and adaptation

(2020) Uday Chand Jha et al.   BMC PLANT BIOLOGY

Functional Characterization of a Putative RNA Demethylase ALKBH6 in Arabidopsis Growth and Abiotic Stress Responses

(2020) Trinh Thi Huong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis inArabidopsis thaliana

(2020) Susheel Sagar Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome-Wide N6-Methyladenosine (m6A) Methylome Profiling of Heat Stress in Pak-choi (Brassica rapa ssp. chinensis)

(2020) Gaofeng Liu et al.   Plants-Basel

Analysis of N6-methyladenosine reveals a new important mechanism regulating the salt tolerance of sweet sorghum

(2020) Hongxiang Zheng et al.   PLANT SCIENCE

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

Transcriptome‐wide analysis of N6‐methyladenosine uncovers its regulatory role in gene expression in the lepidopteran Bombyx mori

(2019) B. Li et al.   INSECT MOLECULAR BIOLOGY

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

N6‐methyladenosine regulatory machinery in plants: composition, function and evolution

(2019) Hong Yue et al.   PLANT BIOTECHNOLOGY JOURNAL

Epitranscriptomic RNA Methylation in Plant Development and Abiotic Stress Responses

(2019) Jianzhong Hu et al.   Frontiers in Plant Science

Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling

(2019) Miguel Angel Garcia-Campos et al.   CELL

Single-base mapping of m6A by an antibody-independent method

(2019) Zhang Zhang et al.   Science Advances

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

(2019) Xiao-Min Liu et al.   Nature Chemical Biology

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication

(2019) Zhenyan Miao et al.   PLANT PHYSIOLOGY

Natural variation in RNA m6A methylation and its relationship with translational status

(2019) Jinhong Luo et al.   PLANT PHYSIOLOGY

Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis

(2018) Jie-Mei Chu et al.   ACS Chemical Biology

SnapShot: Messenger RNA Modifications

(2018) Veronica Davalos et al.   CELL

N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential

(2018) Dandan Yang et al.   NUCLEIC ACIDS RESEARCH

An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis

(2018) Laura Arribas-Hernández et al.   PLANT CELL

The m6A Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis

(2018) Lian-Huan Wei et al.   PLANT CELL

The YTH Domain Protein ECT2 Is an m6A Reader Required for Normal Trichome Branching in Arabidopsis

(2018) Jérémy Scutenaire et al.   PLANT CELL

N6-methyl-adenosine level in Nicotiana tabacum is associated with tobacco mosaic virus

(2018) Zhurui Li et al.   Virology Journal

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

(2018) Baixing Wu et al.   Nature Communications

Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs

(2018) Simone Rauch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

N6-Methyladenosine Inhibits Local Ribonucleolytic Cleavage to Stabilize mRNAs in Arabidopsis

(2018) Stephen J. Anderson et al.   Cell Reports

5-Methylcytosine RNA Methylation in Arabidopsis Thaliana

(2017) Xuean Cui et al.   Molecular Plant

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

(2017) Boxuan Simen Zhao et al.   NATURE

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

(2017) Yuan Zong et al.   NATURE BIOTECHNOLOGY

Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI

(2017) Kamil Růžička et al.   NEW PHYTOLOGIST

ALKBH10B Is an RNAN6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition

(2017) Hong-Chao Duan et al.   PLANT CELL

High-throughput m6A-seq reveals RNA m6A methylation patterns in the chloroplast and mitochondria transcriptomes of Arabidopsis thaliana

(2017) Zegang Wang et al.   PLoS One

Arabidopsism6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs

(2017) Mireya Martínez-Pérez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MhYTP1 and MhYTP2 from Apple Confer Tolerance to Multiple Abiotic Stresses in Arabidopsis thaliana

(2017) Na Wang et al.   Frontiers in Plant Science

N 6 -Methyladenosine RNA Modification Regulates Shoot Stem Cell Fate in Arabidopsis

(2016) Lisha Shen et al.   DEVELOPMENTAL CELL

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

(2016) Dan Dominissini et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

MicroRNAs As Potential Targets for Abiotic Stress Tolerance in Plants

(2016) Varsha Shriram et al.   Frontiers in Plant Science

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis

(2015) Lee E. Vandivier et al.   PLANT CELL

The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis

(2014) Q. Bruggeman et al.   PLANT PHYSIOLOGY

Unique features of the m6A methylome in Arabidopsis thaliana

(2014) Guan-Zheng Luo et al.   Nature Communications

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis

(2013) Schraga Schwartz et al.   CELL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE