Article
Peripheral Vascular Disease
Laura M. Pillay, Joseph J. Yano, Andrew E. Davis, Matthew G. Butler, Keith A. Barnes, Vanessa L. Reyes, Daniel Castranova, Aniket Gore, Matthew R. Swift, James R. Iben, Amber N. Stratman, Brant M. Weinstein, Madeleine Kenton, Megan O. Ezeude, Jong S. Park
Summary: This study investigates the role of RHOA in vascular development and integrity using zebrafish as a model. The findings suggest that both excessive and insufficient RHOA activity can lead to vascular dysfunction.
Article
Ophthalmology
Zhi Li, Jing Zhang, Yanni Xue, Ying He, Lanlan Tang, Min Ke, Yan Gong
Summary: This study revealed that pitavastatin can enhance retinal angiogenesis through multiple mechanisms, in combination with VEGF and LPS showing synergistic effects, independently of the HMG-CoA reductase pathway.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Cell Biology
Tao Zhang, Ruiting Hu, Yan Wang, Shuai Guo, Zhimin Wu, Junfeng Liu, Chunyang Han, Changwei Qiu, Ganzhen Deng
Summary: The integrity of the endometrium is crucial for maintaining fertility, but the mechanisms for repairing uterine injuries are mostly unknown. This study reveals that disturbances in mechanical cues contribute to uterine injury. By identifying YAP as a sensor for biophysical forces, the researchers demonstrated that mechanical cues related to extracellular matrix rigidity can activate YAP and promote uterine remodeling. These findings shed new light on the regulatory mechanisms behind uterine remodeling and mechanotransduction.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Multidisciplinary
Yuhe Yang, Tianpeng Xu, Qiang Zhang, Yun Piao, Ho Pan Bei, Xin Zhao
Summary: The study presents the development of a periosteum mimicking bone aid (PMBA) with enhanced mechanical strength, tissue adhesiveness, and sustained activation of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling pathway for accelerated bone regeneration. This concept involves considering both the initial material components and the degradation products in promoting physiological activities, aiming to inspire the design of high-performance bioscaffolds for bone and periosteum tissue engineering.
Review
Endocrinology & Metabolism
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke, a common and undertreated cerebral disease with high mortality and disability rate, involves various intrinsic and extrinsic factors that regulate the progression. Astrocytes, as an integral part of the neuronal glia system, play crucial roles in neuronal survival after ischemic stroke. The RhoA/ROCK signaling pathway and astrocytes have significant impact on neurological function and tissue repair after brain injury caused by ischemic stroke.
METABOLIC BRAIN DISEASE
(2021)
Editorial Material
Medicine, Research & Experimental
Emilie K. Mitten, Gyorgy Baffy
Summary: This commentary discusses the favorable impact of microbiota transplantation on portal hypertension in an experimental model of cirrhosis. Microbiota transplantation alleviated splanchnic hyperdynamic circulation by improving vascular responsiveness and reducing angiogenesis, as well as reducing blood flow in portosystemic collaterals. However, it had no effect on intrahepatic vasoconstriction in this model.
Article
Cell Biology
Xiao Jiang, Jiandong Hu, Ziru Wu, Sarah Trusso Cafarello, Mario Di Matteo, Ying Shen, Xue Dong, Heike Adler, Massimiliano Mazzone, Carmen Ruiz de Almodovar, Xiaohong Wang
Summary: The protein phosphatase 2A (PP2A) is crucial for YAP activation in endothelial cells, playing an important role in angiogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Maibritt Kretschmer, Daniel Ruediger, Stefan Zahler
Summary: Angiogenesis is crucial for physiological and pathological processes, with the stiffness of the ECM and cell adhesion influencing endothelial cell behavior. Different stages of angiogenesis require various chemical and mechanical cues, with changes in ECM representing potential dysregulations in addition to erroneous biochemical signals during tumor growth.
Article
Chemistry, Medicinal
Ran Deng, Yanhong Bu, Feng Li, Hong Wu, Yan Wang, Wei Wei
Summary: The interactions between FLSs and VECs can promote the release of S1P and affect cellular functions through activation of multiple signaling pathways, while geniposide can block this interaction and alleviate inflammation in rheumatoid arthritis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao
Summary: This study reveals a novel mechanism of cholesterol-mediated TMEM16A inhibition, by which cholesterol reduces TMEM16A expression via DNMT1-mediated methylation and directly inhibits channel activities. TMEM16A channel inhibition promotes endothelial cell angiogenesis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Peripheral Vascular Disease
Mika Sawane, Yuki Ogura, Ayano Nakamura, Hitomi Otaka, Hiroyasu Kidoya, Katsujiro Sato, Nobuyuki Takakura, Kentaro Kajiya
Summary: The study found that appropriate stiffness induces vascular maturation and upregulated APJ expression, while overexpression of APJ promotes the formation of large vessels, potentially providing a novel mechanism for preventing human skin aging.
Review
Cell Biology
Zi-Yi Zhou, Lin Wang, Yu-Sheng Wang, Guo-Rui Dou
Summary: The current treatment for ocular pathological angiogenesis focuses on anti-VEGF signals, but regulation of endothelial glycolysis has emerged as a potential treatment targeting vessel sprouting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Tang, Shashi Kant Tiwari, Kriti Agrawal, Matthew Tan, Jason Dang, Trevor Tam, Jing Tian, Xueyi Wan, Jacob Schimelman, Shangting You, Qinghui Xia, Tariq M. Rana, Shaochen Chen
Summary: This study developed biomimetic tri-regional GBM models to study tumor cell behaviors and angiogenic potentials by mimicking tumor regions, acellular ECM regions, and an endothelial region with different stiffness levels.
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Lucio Diaz-Flores, Jose Luis Carrasco, Juan Francisco Madrid, Aixa Rodriguez Bello
Summary: Perivascular cells, including pericytes and CD34+ stromal cells/telocytes, play an important role in angiogenesis. The behavior and changes of these cells differ depending on the type of angiogenesis, involving various cell-to-cell interactions and signaling pathways. Perivascular cells and CD34+ stromal cells/telocytes have important functions in vessel development and tissue repair, while their involvement in intussusceptive angiogenesis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Article
Respiratory System
Thomas W. Ferkol, Harold J. Farber, Stefania La Grutta, Frank T. Leone, Henry M. Marshall, Enid Neptune, Charlotta Pisinger, Aneesa Vanker, Myra Wisotzky, Gustavo E. Zabert, Dean E. Schraufnagel
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Rheumatology
Elizabeth R. Volkmann, Donald P. Tashkin, Myung Sim, Ning Li, Ellen Goldmuntz, Lynette Keyes-Elstein, Ashley Pinckney, Daniel E. Furst, Philip J. Clements, Dinesh Khanna, Virginia Steen, Dean E. Schraufnagel, Shiva Arami, Vivien Hsu, Michael D. Roth, Robert M. Elashoff, Keith M. Sullivan, P. J. Clements, D. P. Tashkin, R. Elashoff, J. Goldin, M. Roth, D. Furst, K. Bulpitt, D. Khanna, W-L J. Chung, S. Vasco, M. Sterz, L. Woolcock, X. Yan, J. Ho, S. Vasunilashorn, I da Costa, J. R. Seibold, D. J. Riley, J. K. Amorosa, V. M. Hsu, D. A. McCloskey, J. E. Wilson, J. Varga, D. Schraufnagel, A. Wilbur, M. Lopata, S. Arami, P. Cole-Saffold, R. Simms, A. Theodore, P. Clarke, J. Korn, K. Tobin, M. Nuite, R. Silver, M. Bolster, C. Strange, S. Schabel, E. Smith, J. Arnold, K. Caldwell, M. Bonner, R. Wise, F. Wigley, B. White, L. Hummers, M. Bohlman, A. Polito, G. Leatherman, E. Forbes, M. Daniel, V Steen, C. Read, C. Cooper, S. Wheaton, A. Carey, A. Ortiz, M. Mayes, E. Parsley, S. Oldham, T. Filemon, S. Jordan, M. Perry, K. Connolly, J. Golden, P. Wolters, R. Webb, J. Davis, C. Antolos, C. Maynetto, B. Fessler, M. Olman, C. Sanders, L. Heck, T. Parkhill, N. Rothfield, M. Metersky, R. Cobb, M. Aberles, F. Ingenito, E. Breen, K. Mubarak, J. L. Granda, J. Silva, Z. Injic, R. Alexander, S. Springmeyer, S. Kirkland, J. Molitor, R. Hinke, A. Mondt, T. Thompson, S. Rounds, M. Weinstein, B. Thompson, H. Paulus, S. Levy, D. Martin, A. C. Theodore, R. W. Simms, E. Kissin, F. Y. Cheong, V. D. Steen, C. A. Read, C. Fridley, M. Zulmatashvili, R. A. Wise, F. M. Wigley, R. M. Silver, F. N. Hant, J. Ham, K. Gibson, D. Rosson, R. M. Elashoff, M. D. Roth, S. Kafaja, E. Kleerup, D. Elashoff, E. Ariola, G. Marlis, J. Mason-Berry, P. Saffold, M. Rodriguez, L. Guzman, J. Brook, M. K. Connolly, A. Eller, D. Leong, M. Lalosh, J. Obata, S. Volkov, D. Franklin, J. Dematte, M. Hinchcliff, C. DeLuca, H. Donnelly, C. Marlin, K. Phillips, F. J. Martinez, E. Schiopu, J. Konkle, B. Patel, S. Assassi, F. Tan, A. Fischer, J. Swigris, R. Meehan, K. Brown, T. Warren, M. Morrison, M. B. Scholand, T. Frecht, P. Carey, M. Villegas, P. Carlson
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Review
Critical Care Medicine
Dean E. Schraufnagel, John R. Balmes, Clayton T. Cowl, Sara De Matteis, Soon-Hee Jung, Kevin Mortimer, Rogelio Perez-Padilla, Mary B. Rice, Horacio Riojas-Rodriguez, Akshay Sood, George D. Thurston, Teresa To, Anessa Vanker, Donald J. Wuebbles
Review
Critical Care Medicine
Dean E. Schraufnagel, John R. Balmes, Clayton T. Cowl, Sara De Matteis, Soon-Hee Jung, Kevin Mortimer, Rogelio Perez-Padilla, Mary B. Rice, Horacio Riojas-Rodriguez, Akshay Sood, George D. Thurston, Teresa To, Anessa Vanker, Donald J. Wuebbles
Article
Immunology
Mansi Srivastava, Uzma Saqib, Sreeparna Banerjee, Kishore Wary, Burak Kizil, Kannan Muthu, Mirza S. Baig
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Review
Allergy
Tari Haahtela, Leena von Hertzen, Josep M. Anto, Chunxue Bai, Abay Baigenzhin, Eric D. Bateman, Digambar Behera, Kazi Bennoor, Paulo Camargos, Niels Chavannes, Jaime Correia de Sousa, Alvaro Cruz, Maria Do Ceu Teixeira, Marina Erhola, Eeva Furman, Bilun Gemicioglu, Sandra Gonzalez Diaz, Peter W. Hellings, Pekka Jousilahti, Nikolai Khaltaev, Vitezslav Kolek, Piotr Kuna, Stefania La Grutta, Le Thi Tuyet Lan, Tamaz Maglakelidze, Mohamed R. Masjedi, Florin Mihaltan, Yousser Mohammad, Elizabete Nunes, Arvid Nyberg, Jorge Quel, Jose Rosado-Pinto, Hironori Sagara, Boleslaw Samolinski, Dean Schraufnagel, Talant Sooronbaev, Mohamed Tag Eldin, Teresa To, Arunas Valiulis, Cherian Varghese, Tuula Vasankari, Giovanni Viegi, Tonya Winders, Anahi Yanez, Arzu Yorgancioglu, Osman Yusuf, Jean Bousquet, Nils E. Billo
CLINICAL AND TRANSLATIONAL ALLERGY
(2019)
Article
Cell Biology
Vijay Avin Balaji Ragunathrao, Mumtaz Anwar, Md Zahid Akhter, Alejandra Chavez, De Yu Mao, Viswanathan Natarajan, Sribalaji Lakshmikanthan, Magdalena Chrzanowska-Wodnicka, Arkadiusz Z. Dudek, Lena Claesson-Welsh, Jan K. Kitajewski, Kishore K. Wary, Asrar B. Malik, Dolly Mehta
Review
Cell Biology
Jugajyoti Baruah, Kishore K. Wary
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Dean E. Schraufnagel
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Review
Medicine, General & Internal
Dean E. Schraufnagel
CHINESE MEDICAL JOURNAL
(2020)
Article
Multidisciplinary Sciences
Olivia A. Gray, Jennifer Yoo, Debora R. Sobreira, Jordan Jousma, David Witonsky, Noboru J. Sakabe, Ying-Jie Peng, Nanduri R. Prabhakar, Yun Fang, Marcelo A. Nobrega, Anna Di Rienzo
Summary: In Tibetans, noncoding alleles in the EPAS1 gene have strong signatures of positive selection. This study found that high-altitude alleles disrupt the activity of enhancers in the EPAS1 gene, and one specific enhancer, ENH5, is both allele specific and hypoxia dependent. The findings suggest that the pleiotropic adaptive effects of these alleles in multiple cell types underlie the strong selective signal at the EPAS1 gene.
Article
Cell Biology
Xiaojia Huang, Xianming Zhang, Narsa Machireddy, Colin E. Evans, Shawn D. Trewartha, Guochang Hu, Yun Fang, Goekhan M. Mutlu, David Wu, You-Yang Zhao
Summary: Aging impairs endothelial regeneration and vascular repair, leading to increased mortality in acute respiratory distress syndrome (ARDS) after sepsis challenge. Reactivation of the FoxM1 gene or treatment with the DNA demethylating agent decitabine promotes endothelial regeneration, normalizes vascular repair and resolution of inflammation, and improves survival in aged mice. FOXM1 induction is impaired in elderly patients with ARDS, suggesting that targeting FoxM1-mediated endothelial regeneration may be a potential therapy for this population.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemical Research Methods
Devin Harrison, David Wu, Jun Huang, Yun Fang
Summary: The protocol utilizes deep learning image analysis to accurately quantify metabolite levels and glycolytic rates at the single-cell level, allowing discrimination of metabolically diverse subpopulations and direct linking of metabolism to functional phenotypes.
Letter
Respiratory System
Dean E. Schraufnagel, Sara De Matteis, Barbara Hoffmann
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2020)
Review
Respiratory System
Dean E. Schraufnagel, John R. Balmes, Sara De Matteis, Barbara Hoffman, Woo Jin Kim, Rogelio Perez-Padilla, Mary Rice, Akshay Sood, Aneesa Vanker, Donald J. Wuebbles
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2019)