Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction

A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins

(2016) Anne Gaebler et al.   JOURNAL OF LIPID RESEARCH

Elucidating the chemical structure of native 1-deoxysphingosine

(2016) Regula Steiner et al.   JOURNAL OF LIPID RESEARCH

1-Deoxysphingolipid-induced neurotoxicity involves N-methyl- d -aspartate receptor signaling

(2016) Tanja Güntert et al.   NEUROPHARMACOLOGY

Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy

(2015) Rita Kramer et al.   FASEB JOURNAL

Identification of dietary alanine toxicity and trafficking dysfunction in aDrosophilamodel of hereditary sensory and autonomic neuropathy type 1

(2015) Matthew C. W. Oswald et al.   HUMAN MOLECULAR GENETICS

HSAN1 mutations in serine palmitoyltransferase reveal a close structure–function–phenotype relationship

(2015) Heiko Bode et al.   HUMAN MOLECULAR GENETICS

1-Deoxysphingolipids Encountered Exogenously and Madede Novo: Dangerous Mysteries inside an Enigma

(2015) Jingjing Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation

(2015) Kayoko Esaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

(2015) D. Lee Gorden et al.   JOURNAL OF LIPID RESEARCH

Novel HSAN1 Mutation in Serine Palmitoyltransferase Resides at a Putative Phosphorylation Site That Is Involved in Regulating Substrate Specificity

(2015) Daniela Ernst et al.   NEUROMOLECULAR MEDICINE

Mitochondrial dynamics and inherited peripheral nerve diseases

(2015) Davide Pareyson et al.   NEUROSCIENCE LETTERS

Fat & fabulous: Bifunctional lipids in the spotlight

(2014) Per Haberkant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multiple bonds for the lipid interest

(2014) Lars Kuerschner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The regulation of mitochondrial dynamics

(2014) Suzanne Hoppins   CURRENT OPINION IN CELL BIOLOGY

Lowering Plasma 1-Deoxysphingolipids Improves Neuropathy in Diabetic Rats

(2014) Alaa Othman et al.   DIABETES

Mutations in the SPTLC1 Protein Cause Mitochondrial Structural Abnormalities and Endoplasmic Reticulum Stress in Lymphoblasts

(2014) Simon J. Myers et al.   DNA AND CELL BIOLOGY

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

(2014) Gary J. Bennett et al.   Nature Reviews Neurology

Mutations at Ser331 in the HSN type I gene SPTLC1 are associated with a distinct syndromic phenotype

(2013) Michaela Auer-Grumbach et al.   European Journal of Medical Genetics

A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization

(2013) Kristina Hofmann et al.   JOURNAL OF LIPID RESEARCH

Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays

(2013) Anne Gaebler et al.   JOURNAL OF LIPID RESEARCH

Straightforward Access to Spisulosine and 4,5-Dehydrospisulosine Stereoisomers: Probes for Profiling Ceramide Synthase Activities in Intact Cells

(2013) José Luis Abad et al.   JOURNAL OF ORGANIC CHEMISTRY

Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2

(2013) S. M. Murphy et al.   NEUROLOGY

Tracing Fatty Acid Metabolism by Click Chemistry

(2012) Christoph Thiele et al.   ACS Chemical Biology

Phase I dose-escalating study of ES-285 given as a three-hour intravenous infusion every three weeks in patients with advanced malignant solid tumors

(2012) C. Massard et al.   INVESTIGATIONAL NEW DRUGS

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

P42 Hereditary sensory neuropathy type 1: correlation of severity and plasma atypical deoxy-sphyngoid bases

(2012) M. Lauraá et al.   NEUROMUSCULAR DISORDERS

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

(2011) P. Schöffski et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?

(2011) A. Othman et al.   DIABETOLOGIA

Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I

(2011) Annelies Rotthier et al.   HUMAN MUTATION

Novel Pathway of Ceramide Production in Mitochondria

(2011) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral l-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

(2011) Kevin Garofalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

(2011) W.H. Xiao et al.   NEUROSCIENCE

Electrical Activity Suppresses Axon Growth through Cav1.2 Channels in Adult Primary Sensory Neurons

(2010) Joana Enes et al.   CURRENT BIOLOGY

A phase I dose-escalating study of ES-285, a marine sphingolipid-derived compound, with repeat dose administration in patients with advanced solid tumors

(2010) Eduardo Vilar et al.   INVESTIGATIONAL NEW DRUGS

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids

(2010) Anke Penno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deoxysphingoid bases as plasma markers in Diabetes mellitus

(2010) Mariana Bertea et al.   Lipids in Health and Disease

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts

(2009) Ralf Frederik Claas et al.   CELLULAR SIGNALLING

Overexpression of the Wild-Type SPT1 Subunit Lowers Desoxysphingolipid Levels and Rescues the Phenotype of HSAN1

(2009) F. S. Eichler et al.   JOURNAL OF NEUROSCIENCE

Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors

(2009) R. D. Baird et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Synthase Inhibition by Fumonisin B1Causes Accumulation of 1-Deoxysphinganine

(2008) Nicholas C. Zitomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY