Epigallocatechin-3-gallate ameliorates autoimmune arthritis by reciprocal regulation of T helper-17 regulatory T cells and inhibition of osteoclastogenesis by inhibiting STAT3 signaling

A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of Type 1 diabetes in NOD mice

(2014) Palash Bhattacharya et al.   CLINICAL IMMUNOLOGY

Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model

(2014) Chao-Lin Kuo et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay

(2014) H. A. Elshabrawy et al.   JOURNAL OF VIROLOGY

TREG-cell therapies for autoimmune rheumatic diseases

(2014) Makoto Miyara et al.   Nature Reviews Rheumatology

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control

(2014) Eun-Ji Yang et al.   PLoS One

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

(2013) Behdad Afzali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigallocatechin-3-gallate ameliorates both obesity and autoinflammatory arthritis aggravated by obesity by altering the balance among CD4+ T-cell subsets

(2013) Jae-Kyeong Byun et al.   IMMUNOLOGY LETTERS

The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis

(2013) Z. Chen et al.   JOURNAL OF IMMUNOLOGY

Green tea polyphenol, (−)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling

(2013) Tripti Singh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway

(2012) Saba Alzabin et al.   ANNALS OF THE RHEUMATIC DISEASES

Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells

(2012) Ji Hyeon Ju et al.   ARTHRITIS AND RHEUMATISM

A Novel Combination of Methotrexate and Epigallocatechin Attenuates the Overexpression of Pro-inflammatory Cartilage Cytokines and Modulates Antioxidant Status in Adjuvant Arthritic Rats

(2012) Souvik Roy et al.   INFLAMMATION

EGCG Enhances the Therapeutic Potential of Gemcitabine and CP690550 by Inhibiting STAT3 Signaling Pathway in Human Pancreatic Cancer

(2012) Su-Ni Tang et al.   PLoS One

Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing

(2012) Hatem A. Elshabrawy et al.   PLoS One

EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes

(2012) Sung Gu Han et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

(2012) Iannis E Adamopoulos et al.   ARTHRITIS RESEARCH & THERAPY

Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease

(2011) Nuria Maicas et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 бvia Stat3 in gastric cancer

(2011) Bao-He Zhu   WORLD JOURNAL OF GASTROENTEROLOGY

Pharmacologic Inhibition of MEK–ERK Signaling Enhances Th17 Differentiation

(2010) Andy Hee-Meng Tan et al.   JOURNAL OF IMMUNOLOGY

Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor α-induced apoptosis

(2009) Salahuddin Ahmed et al.   ARTHRITIS AND RHEUMATISM

Epigallocatechin-3-gallate Inhibits Osteoclastogenesis by Down-Regulating c-Fos Expression and Suppressing the Nuclear Factor- B Signal

(2009) J.-H. Lee et al.   MOLECULAR PHARMACOLOGY

(−)‐Epigallocatechin‐3‐gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice

(2008) Akio Morinobu et al.   ARTHRITIS AND RHEUMATISM

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Green Tea Protects Rats against Autoimmune Arthritis by Modulating Disease-Related Immune Events

(2008) Hong Ro Kim et al.   JOURNAL OF NUTRITION

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production

(2008) S. Ahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigallocatechin-3-gallate suppresses TNF-α -induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts

(2008) Hee-Jin Yun et al.   RHEUMATOLOGY INTERNATIONAL

TH-17 cells in rheumatoid arthritis

(2008) Shiva Shahrara et al.   ARTHRITIS RESEARCH & THERAPY

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG

(2007) Hye-Kyung Na et al.   FOOD AND CHEMICAL TOXICOLOGY