Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2 −/− mice

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial

(2014) Frank Behrens et al.   ANNALS OF THE RHEUMATIC DISEASES

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

(2014) Avraham Ben-Nun et al.   JOURNAL OF AUTOIMMUNITY

Loss of STAT3 in CD4 + T Cells Prevents Development of Experimental Autoimmune Diseases

(2014) Xuebin Liu et al.   JOURNAL OF IMMUNOLOGY

GM-CSF–Neuroantigen Fusion Proteins Reverse Experimental Autoimmune Encephalomyelitis and Mediate Tolerogenic Activity in Adjuvant-Primed Environments: Association with Inflammation-Dependent, Inhibitory Antigen Presentation

(2014) S. M. Touhidul Islam et al.   JOURNAL OF IMMUNOLOGY

Relapsing-Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells

(2014) K. Sasaki et al.   JOURNAL OF IMMUNOLOGY

Treating multiple sclerosis with monoclonal antibodies: a 2013 update

(2013) Annika Deiß et al.   Expert Review of Neurotherapeutics

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

OX40L/Jagged1 Cosignaling by GM-CSF-Induced Bone Marrow-Derived Dendritic Cells Is Required for the Expansion of Functional Regulatory T Cells

(2013) A. Gopisetty et al.   JOURNAL OF IMMUNOLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis

(2012) Mark D. Mannie et al.   Frontiers in Immunology

Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

(2011) Derek J Abbott et al.   BMC IMMUNOLOGY

TH17 cytokines in autoimmune neuro-inflammation

(2011) Burkhard Becher et al.   CURRENT OPINION IN IMMUNOLOGY

The Immune Pathogenesis of Experimental Autoimmune Encephalomyelitis: Lessons Learned for Multiple Sclerosis?

(2011) Stefanie Kuerten et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis

(2011) Jian Rong Sheng et al.   JOURNAL OF NEUROIMMUNOLOGY

GM-CSF: the secret weapon in the TH17 arsenal

(2011) Mandy J McGeachy   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

GM-CSF induces bone marrow precursors of NOD mice to skew into tolerogenic dendritic cells that protect against diabetes

(2010) Simon Gaudreau et al.   CELLULAR IMMUNOLOGY

EAE mediated by a non-IFN-γ/non-IL-17 pathway

(2010) Mark A. Kroenke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GM-CSF–dependent, CD103+dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization

(2010) Irah L. King et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

(2010) Palash Bhattacharya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function

(2009) Donald Cheatem et al.   CLINICAL IMMUNOLOGY

GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis

(2009) B. B. Ganesh et al.   INTERNATIONAL IMMUNOLOGY

A GMCSF-neuroantigen fusion protein is a potent tolerogen in experimental autoimmune encephalomyelitis (EAE) that is associated with efficient targeting of neuroantigen to APC

(2009) J. L. Blanchfield et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis

(2008) Jian Rong Sheng et al.   CLINICAL IMMUNOLOGY

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE