Review
Oncology
Michelle Yee Mun Teo, Jung Yin Fong, Wan Ming Lim, Lionel Lian Aun In
Summary: Kirsten Rat Sarcoma (KRAS) gene somatic point mutations are highly prevalent in colorectal cancer, and targeting undruggable kinases and kinase-substrate molecules has shown promise as a therapeutic approach. Combination treatments involving MEK inhibitors and PI3K inhibitors have been shown to be effective in preventing the development of resistance and improving therapeutic outcomes in patients with metastatic colorectal cancer. Ongoing clinical trials are evaluating the use of these pathway inhibitors in combination with immunotherapy for patients with limited treatment options. This review discusses the latest scientific approaches and clinical trials targeting KRAS mutations for the management of colorectal cancer.
MOLECULAR CANCER RESEARCH
(2022)
Review
Medical Laboratory Technology
Federico V. Pallardo, Giovanni Pagano, Laura R. Rodriguez, Pilar Gonzalez-Cabo, Alex Lyakhovich, Marco Trifuoggi
Summary: Friedreich's Ataxia is an autosomal recessive genetic disease caused by frataxin deficiency, and research suggests that a combination strategy involving iron chelators, antioxidants, and mitochondrial cofactors may help mitigate the disease progression.
TRANSLATIONAL RESEARCH
(2021)
Review
Medicine, General & Internal
Andres Garcia-Sampedro, Gabriella Gaggia, Alexander Ney, Ismahan Mahamed, Pilar Acedo
Summary: Pancreatic cancer has a poor prognosis, and surgery with adjuvant chemotherapy is the only curative option for a small group of patients. Novel therapeutic strategies are urgently needed for advanced or metastatic cases where surgical resection is not possible. Molecular profiling and targeted therapies show promise in overcoming the limitations of conventional treatments. Currently, personalized and multimodal targeted therapies are undergoing clinical trials with promising results targeting various aspects of pancreatic cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Green & Sustainable Science & Technology
Yulin Si, Xiaodong Liu, Tao Wang, Bo Feng, Peng Qian, Yong Ma, Dahai Zhang
Summary: Due to its predictability and high power density, tidal current energy has gained significant attention globally in the past decade. China is also actively developing tidal current energy to meet the increasing power demands of coastal cities and islands. This paper presents the latest developments in tidal current energy conversion technology in China, including scale, efficiency, reliability, and innovation. The study reveals that China's tidal current energy conversion is moving in two different directions: large-scale turbines for grid connection and small-scale turbines for various marine applications.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Review
Oncology
Liang Rong, Ni Li, Zhenzhen Zhang
Summary: Glioblastoma (GBM) is a common brain tumor with poor prognosis. Immunotherapy, including immune checkpoint blockade, CAR T cell therapy, oncolytic virotherapy, and vaccine therapy, has shown promising results in improving GBM outcomes. Techniques to overcome the blood-brain barrier for targeted delivery are also being tested. This article reviews the rationales for these therapies, potential novel agents, current status of trials, and discusses challenges and future perspectives in glioblastoma immuno-oncology.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Umair Majeed, Rami Manochakian, Yujie Zhao, Yanyan Lou
Summary: Lung cancer remains a leading cause of cancer mortality, with non-small cell lung cancer being the most common type. Targeted therapy can provide durable responses, and advances in molecular and immunohistochemical techniques allow for personalized medicine.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Rossella Reddavid, Simona Dagatti, Caterina Franco, Lucia Puca, Mariano Tomatis, Simona Corso, Silvia Giordano, Maurizio Degiuli
Summary: Despite the addition of molecular therapy in the clinical treatment of advanced and metastatic gastric cancer, the survival benefits of these novel therapies remain rather unclear, possibly due to inaccurate patient selection.
Review
Oncology
Katarzyna Stencel, Izabela Chmielewska, Janusz Milanowski, Rodryg Ramlau
Summary: The use of novel therapeutic drugs in lung cancer has revolutionized the diagnosis and treatment paradigms, with many new targeted therapies approved by the FDA or in clinical trials. Lung cancer remains a leading cause of cancer-related deaths globally, and specific genetic alterations indicate the suitability for targeted therapies.
Review
Biochemistry & Molecular Biology
Horatiu Silaghi, Vera Lozovanu, Carmen Emanuela Georgescu, Cristina Pop, Bogdana Adriana Nasui, Adriana Florinela Catoi, Cristina Alina Silaghi
Summary: This article summarizes the conventional management of differentiated thyroid cancer (DTC) and introduces the first-line and alternative approaches using tyrosine kinase inhibitors (TKIs) in treating refractory DTC. It also discusses strategies to overcome resistance to MAPK and PI3K pathway inhibitors. Additionally, the article highlights the latest achievements in redifferentiation therapy, immunotherapy, and targeted gene rearrangement therapies for advanced DTC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Arthur H. A. Sales, Juergen Beck, Oliver Schnell, Christian Fung, Bernhard Meyer, Jens Gempt
Summary: In this study, a comprehensive literature review was conducted to explore the current state and future trends of surgical treatment for glioblastoma (GBM), with a focus on recent research topics.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sebastian Gottfried Walter, Peter Knoell, Peer Eysel, Alexander Quaas, Christopher Gaisendrees, Robert Nissler, Lena Hieggelke
Summary: Chondrosarcoma is a rare bone tumor that is usually treated by complete resection. When resection is not possible, treatment options are limited. Compared to other types of tumors, chondrosarcoma is still not well understood. Identifying specific molecules and tumor cells of chondrosarcoma will aid in the development of improved therapies in the future.
Review
Oncology
Sujit S. Nair, Dimple Chakravarty, Vaibhav Patel, Nina Bhardwaj, Ashutosh K. Tewari
Summary: Neoadjuvant therapies are important for reducing tumor volume, facilitating surgery, and assessing treatment response. They have the potential to improve survival in patients with localized or locally advanced genitourinary cancer. The use of biomarkers and comprehensive studies will advance precision neoadjuvant therapies.
Article
Computer Science, Hardware & Architecture
Rajni Gupta, Juhi Gupta
Summary: Federated learning (FL) is a promising paradigm that enables devices to learn without sharing data with a centralized server. Game theory (GT) is used to optimize the complicated interactions between the server and edge devices to maximize utility. This review article presents the latest research on GT-based FL models, covering topics such as profit maximization, authentication, privacy management, trust management, and threat detection. The article also includes a bibliometric analysis and highlights key challenges and future approaches for efficient GT-based FL models.
Article
Oncology
Yongji Zeng, Ramon U. Jin
Summary: Gastric cancer is a major cause of global cancer mortality, characterized by molecular diversity and heterogeneous pathogenesis. By studying molecular targeted therapies, immunotherapies, single-cell molecular analyses, and organoid technologies, personalized treatments for gastric cancer can be advanced to improve outcomes and future prevention strategies.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Endocrinology & Metabolism
George Alyateem, Naris Nilubol
Summary: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, requiring complete surgical resection and systemic therapy. However, systemic therapy for ACC has limited efficacy and high toxicities, highlighting the need for research on altered molecular pathways to identify effective treatment options. This review discusses recent advances in molecular profiling of ACC and the implications for translational therapeutics, as well as summarizing recent clinical trial results.
FRONTIERS IN ENDOCRINOLOGY
(2021)