Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD

(2022) Chi Ma et al.   CANCER CELL

Persistently higher serum sCD40L levels are associated with outcome in septic patients

(2021) Yingjian Liang et al.   BMC Anesthesiology

Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca2+ Response in Mice

(2021) Yansong Li et al.   NEUROCHEMICAL RESEARCH

Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities

(2021) Adam de Havenon et al.   STROKE

Examination of intestinal ultrastructure, bowel wall apoptosis and tight junctions in the early phase of sepsis

(2020) Beate Obermüller et al.   Scientific Reports

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint

(2020) TingTing Tang et al.   PHARMACOLOGY & THERAPEUTICS

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

(2019) Qiongyuan Hu et al.   EBioMedicine

Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel‐Hyporesponsive Patients

(2019) Megan E. Barra et al.   PHARMACOTHERAPY

Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor

(2019) Jianbin Bi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of BCL-2 in the Intestinal Epithelium Prevents Sepsis-Induced Gut Barrier Function Via Altering Tight Junction Protein Expression

(2019) Shunsuke Otani et al.   SHOCK

Single-Cell Analysis for Glycogen Localization and Metabolism in Cultured Astrocytes

(2019) Yuanyuan Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Platelet glycoprotein receptor Ib blockade ameliorates experimental cerebral ischemia–reperfusion injury by strengthening the blood–brain barrier function and anti-thrombo-inflammatory property

(2018) Chunyan Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function

(2018) Nathalie Vergnolle et al.   PHYSIOLOGY

Platelet activation and antiplatelet therapy in sepsis: A narrative review

(2018) Yuhui Wang et al.   THROMBOSIS RESEARCH

The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels

(2018) Zuo-Liang Liu et al.   Biomed Research International

Intestinal hyperpermeability: a gateway to multi-organ failure?

(2018) QiQi Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure

(2018) Milena Armacki et al.   JOURNAL OF CLINICAL INVESTIGATION

Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function

(2018) Sabine Schneider et al.   Annual Review of Physiology

Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice

(2017) Meenakshi Rao et al.   GASTROENTEROLOGY

Non-survivor septic patients have persistently higher serum sCD40L levels than survivors

(2017) Leonardo Lorente et al.   JOURNAL OF CRITICAL CARE

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

(2017) Antoine Dewitte et al.   Annals of Intensive Care

Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study

(2016) Yu-Hang Ai et al.   CHINESE MEDICAL JOURNAL

Enteric glia: the most alimentary of all glia

(2016) Vladimir Grubišić et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exogenous S-nitrosoglutathione attenuates inflammatory response and intestinal epithelial barrier injury in endotoxemic rats

(2016) Zhifeng Li et al.   Journal of Trauma and Acute Care Surgery

Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases

(2016) Elizabeth A. Middleton et al.   PHYSIOLOGICAL REVIEWS

Exogenous S-nitrosoglutathione attenuates inflammatory response and intestinal epithelial barrier injury in endotoxemic rats

(2016) Zhifeng Li et al.   Journal of Trauma and Acute Care Surgery

Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo

(2016) Corinna Rosenbaum et al.   PLoS One

Discovery of Small Molecule CD40–TRAF6 Inhibitors

(2015) Barbara Zarzycka et al.   Journal of Chemical Information and Modeling

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(2015) Monique Michels et al.   MOLECULAR MEDICINE

Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice

(2015) Ki Churl Chang   THROMBOSIS RESEARCH

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

(2015) Zhihui Yang et al.   TRENDS IN NEUROSCIENCES

Enteric Glial Cells: Recent Developments and Future Directions

(2014) Michel Neunlist et al.   GASTROENTEROLOGY

Understanding hypovolaemia

(2014) Anders Perner et al.   INTENSIVE CARE MEDICINE

Enteric glial cells and their role in the intestinal epithelial barrier

(2014) Yan-Bo Yu   WORLD JOURNAL OF GASTROENTEROLOGY

Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit

(2014) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

Inhibition of IKKβ in Enterocytes Exacerbates Sepsis-Induced Intestinal Injury and Worsens Mortality

(2013) Jessica A. Dominguez et al.   CRITICAL CARE MEDICINE

Enteric Glia Cells Attenuate Cytomix-Induced Intestinal Epithelial Barrier Breakdown

(2013) Gerald A. Cheadle et al.   PLoS One

Antiplatelet Drugs

(2012) John W. Eikelboom et al.   CHEST

Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury

(2012) Zhenju Song et al.   Journal of Translational Medicine

Novel functional roles for enteric glia in the gastrointestinal tract

(2012) Brian D. Gulbransen et al.   Nature Reviews Gastroenterology & Hepatology

Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-κB inactivation: Not involved in cAMP mechanisms

(2010) Won Sun Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of intestinal epithelial cells transcriptome by enteric glial cells: impact on intestinal epithelial barrier functions

(2009) Laurianne Van Landeghem et al.   BMC GENOMICS

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols