Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: The article by Pallud et al. discusses the significant improvement in survival observed in glioma patients with isocitrate dehydrogenase wild-type who received levetiracetam throughout the standard chemoradiation protocol.
Article
Neurosciences
Banu Sacli-Bilmez, Ayca Ersen Danyeli, M. Cengiz Yakicier, Fuat Kaan Aras, M. Necmettin Pamir, Koray Ozduman, Alp Dincer, Esin Ozturk-Isik
Summary: This study analyzed the metabolic correlates of survival in Glioblastoma, IDH-wildtype, WHO grade-4 patients using H-1-MRS and found that Glx and GSH are important metabolic factors for patient survival.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Ali S. Haider, Chibawanye I. Ene, Paolo Palmisciano, Maryam Haider, Ganesh Rao, Leomar Y. Ballester, Gregory N. Fuller
Summary: IDH mutations play a crucial role in glioma classification, with specific substitutions in IDH1 and IDH2 genes. We present a case of diffuse astrocytoma progressing to secondary glioblastoma with concurrent IDH1/IDH2 mutations. Although the occurrence of simultaneous IDH1/IDH2 mutations is rare, further studies are needed to determine their impact on prognosis and response to targeted therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Shouchao Wang, Feng Xiao, Wenbo Sun, Chao Yang, Chao Ma, Yong Huang, Dan Xu, Lanqing Li, Jun Chen, Huan Li, Haibo Xu
Summary: This study aimed to develop a radiomics signature for preoperative prognosis prediction of IDH-wild-type GBM patients and provide personalized assistance in clinical decision-making. The radiomics and combined models can effectively stratify high- and low-risk patients and obtained good prediction consistency and calibration curve consistency.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiman Wu, Xi Zhang, Wenting Rui, Yaru Sheng, Yang Yu, Yong Zhang, Zhenwei Yao, Tianming Qiu, Yan Ren
Summary: This study aimed to construct a radiomics nomogram based on multiparametric MRI data for predicting IDH and ATRX mutation status in patients with lower-grade gliomas (LrGG). The nomogram showed good performance in predicting IDH and ATRX mutation status, providing a clinically useful approach for noninvasive diagnosis of LrGG patients.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Venkatesh S. Madhugiri, Subeikshanan Venkatesan, Akshat Dutt, Aliasgar V. Moiyadi, Prakash Shetty, Tejpal Gupta, Sridhar Epari, Rakesh Jalali, Gopalakrishnan M. Sasidharan, V. R. Roopesh Kumar, C. V. Shankar Ganesh, Andi Sadayandi Ramesh, A. Sathia Prabhu, Anil Kumar Dutt
Summary: This study aimed to investigate the alterations in eosinophil-based and basophil-based indices in patients with GBM and their correlation with patient-related and tumor-related factors and survival. The results showed that all the indices were altered in patients with GBM compared to healthy controls. The absolute eosinophil count was consistently higher in the better prognosis groups and was found to independently predict survival.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Yosef Laviv, Sharon Berkowitz, Andrew K. Kanner, Suzana Fichman, Alexandra Benouaich-Amiel, Tali Siegal, Shlomit Yust-Katz
Summary: This study retrospectively investigated newly diagnosed GBM patients and found that GCs are present in a minority of adult GBM cases, with minimal implications on clinical practice. A higher percentage of GCs may be associated with worse prognosis, distinct radiological features, and increased prevalence of IDH mutations.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gabriele Polonara, Denis Aiudi, Alessio Iacoangeli, Alessio Raggi, Matteo Maria Ottaviani, Ruggero Antonini, Maurizio Iacoangeli, Mauro Dobran
Summary: This study evaluates the prognostic significance of the extent of surgical resection in glioblastoma patients. The results show that maximal surgical resection involving areas of fluid-attenuated inversion recovery (FLAIR) abnormalities improves overall survival.
Review
Radiology, Nuclear Medicine & Medical Imaging
Ziqin Han, Qiuying Chen, Lu Zhang, Xiaokai Mo, Jingjing You, Luyan Chen, Jin Fang, Fei Wang, Zhe Jin, Shuixing Zhang, Bin Zhang
Summary: This study revealed a radiogenomic correlation between the presence of the T2-FLAIR mismatch sign on MR images and isocitrate dehydrogenase (IDH) mutation status in adult patients with lower-grade gliomas (LGGs). The T2-FLAIR mismatch sign could potentially serve as a non-invasive imaging biomarker for the selection of patients with IDH-mutant LGGs.
EUROPEAN RADIOLOGY
(2022)
Article
Immunology
Xiaomin Cai, Zheng Chen, Caiquan Huang, Jie Shen, Wenxian Zeng, Shuang Feng, Yu Liu, Shiting Li, Ming Chen
Summary: This study aimed to construct a prognostic signature based on glycolysis-related genes (GRGs) for IDH1-associated glioblastoma multiforme (GBM) and investigate its relationship with immunity. Through genomic data analysis and statistical methods, GRGs that were associated with prognosis were identified and a prognostic signature was constructed. Further validation showed that the prognostic signature independently predicted the prognosis of GBM patients and was significantly correlated with clinical characteristics, tumor immunogenicity, and immune infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yi Lin, Baoshi Chen
Summary: Tumor-treating fields (TTFields) have shown to be a valuable treatment option in controlling clinical symptom burden and prolonging progression-free survival in a 46-year-old man with anaplastic astrocytoma. Combined use of TTFields and chemotherapy may be beneficial in reducing the risk for pathological upgradation.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Fatima Tensaouti, Franck Desmoulin, Julia Gilhodes, Margaux Roques, Soleakhena Ken, Jean -Albert Lotterie, Georges Noel, Gilles Truc, Marie -Pierre Sunyach, Marie Charissoux, Nicolas Magne, Vincent Lubrano, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: This study aimed to identify different components of glioblastoma subtypes using a large MRSI dataset and determine their association with progression-free survival. The results showed that pre-radiotherapy MRSI can reveal tumor heterogeneity and clusters with metabolic abnormalities and high lactate are predictive of PFS.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Clinical Neurology
Tuomas Natukka, Joonas Haapasalo, Tomi Kivioja, Linnea Rajala, Jani Raitanen, Jaakko Nevalainen, Sirpa-Liisa Lahtela, Kristiina Nordfors, Minna Rauhala, Arja Jukkola, Juhana Frosen, Pauli Helen, Anssi Auvinen, Hannu Haapasalo
Summary: The study aimed to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase-wild-type (IDH-wt) glioblastomas. The results showed that the time interval from referral to surgery within 4-10 weeks was not associated with decreased survivals in IDH-wt glioblastomas, while a delay exceeding 30 days from surgery to adjuvant treatment may decrease long-term survival.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Feng-Min Liu, Yu-Fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo, Wei Hua
Summary: The SUVmax on PET can predict IDH1 mutation with high sensitivity and specificity, supported by reduced glucose consumption in IDH1 mutant gliomas, as evidenced by changes in glucose quantity and metabolic enzyme expression levels.
Article
Oncology
Amrit L. Pappula, Shayaan Rasheed, Golrokh Mirzaei, Ruben C. Petreaca, Renee A. Bouley
Summary: Glioma patients with IDH1 mutation show significant genetic differences compared to patients with wild-type IDH1, including co-mutations and gene expression levels, which may contribute to a better prognosis.
Article
Clinical Neurology
Ye Yoon Suh, Kwanghoon Lee, Yu-Mi Shim, Ji Hoon Phi, Chul-Kee Park, Seung-Ki Kim, Seung Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: The MYB/MYBL1::QKI fusion activates the oncogene MYB and deletes the tumor suppressor gene QKI. Previously, this fusion was only reported in angiocentric glioma (AG) and diffuse low-grade glioma. This study compares two tumors with the MYB/MYBL1::QKI fusion: a diffuse pediatric-type high-grade glioma (DPedHGG) in an 11-year-old boy and an AG in a 46-year-old woman. Characterization using immunohistochemistry, next-generation sequencing, and methylation profiling reveals their molecular characteristics and supports the presence of MYB/MYBL1 alterations in higher-grade gliomas.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
M. E. Buckland, C. Sarkar, V. Santosh, M. Al-Hussaini, S. H. Park, T. Tihan, H. K. Ng, T. Komori
Article
Clinical Neurology
Tae-Hwan Park, Kyung Hyun Kim, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Ji Yeoun Lee
Summary: Fibrous hamartoma of infancy (FHI) is a rare benign soft tissue lesion that usually occurs in infants and young children within the first 2 years of life. FHI in the central nervous system (CNS) is extremely rare, with only two cases of spinal cord FHI reported so far. We present a unique case of FHI in a 1-month-old girl with a skin dimple in the coccygeal area, where both a skin lesion and an intramedullary mass were diagnosed as FHI. Despite being diagnosed with a neurogenic bladder, the patient maintained normal neurological function and showed good mobility during the 5.5-year follow-up period.
CHILDS NERVOUS SYSTEM
(2023)
Review
Clinical Neurology
Hyunhee Kim, Kwanghoon Lee, Ji Hoon Phi, Sun Ha Paek, Hongseok Yun, Seung Hong Choi, Sung-Hye Park
Summary: This study presents the clinicopathological and molecular genetic characteristics of a neuroepithelial tumor (NET) with EWSR1::PATZ1 fusion, which has recently been discovered in rare central nervous system tumors and soft tissue sarcomas. Two cases of this fusion were identified, with the pediatric case showing a high-grade tumor and longer survival compared to conventional glioblastoma. The TERT promoter mutation may serve as an indicator of high-grade behavior in PATZ1 fusion NET.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Hyunhee Kim, Kwanghoon Lee, Yu -Mi Shim, Eric Eunshik Kim, Seung-Ki Kim, Ji Hoon Phi, Chul-Kee Park, Seung Hong Choi, Sung-Hye Park
Summary: Central neurocytoma is a low-grade neuronal tumor that mainly occurs in the lateral ventricle, and the genetic abnormalities that cause this tumor are poorly understood. Through the study of immunomarkers in fetal and adult brains, as well as supratentorial periventricular tumors, the biomarkers, cell of origin, and tumorigenesis of central neurocytoma were characterized. Immunohistochemical analysis showed that central neurocytomas were positive for certain markers, including FGFR3, SSTR2, TTF-1, GLUT-1, and L1CAM.
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Jung Oh Lee, Sung Soo Ahn, Kyu Sung Choi, Junhyeok Lee, Joon Jang, Jung Hyun Park, Inpyeong Hwang, Chul-Kee Park, Sung Hye Park, Jin Wook Chung, Seung Hong Choi
Summary: This study investigated the prognostic value of spatial features from whole-brain MRI using a three-dimensional convolutional neural network for adult-type diffuse gliomas. The results showed that the MRI-based prognostic index model had good predictive performance, and combining clinical, molecular genetic, and imaging data improved the performance of the prediction model.
Article
Oncology
Jee Ye Kahng, Byung-Hee Kang, Soon-Tae Lee, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Jae-Kyung Won, Sung-Hye Park, Jaeman Son, Joo Ho Lee
Summary: This study investigated the relationship between neural stem cells (NSCs) in the subventricular zone (SVZ) and glioblastoma (GBM), as well as the impact of radiotherapeutic strategies. The results showed that GBM patients without SVZ involvement had longer progression-free survival, while patients with GBM in contact with NSCs showed better prognosis after NSC irradiation. This study is of great significance for understanding the origin and treatment of GBM.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Seung Won Choi, Hyun Ae Jung, Hee-Jin Cho, Tae Min Kim, Chul-Kee Park, Do-Hyun Nam, Se-Hoon Lee
Summary: This study evaluated the therapeutic efficacy of the novel anti-EGFR monoclonal antibody GC1118 in recurrent GBM patients with EGFR amplification. Although the study did not meet the primary endpoint, it was found that immune-related signatures were significantly upregulated in tumors with regression upon GC1118 therapy, indicating the potential immune-mediated antitumor efficacy of GC1118.
Correction
Multidisciplinary Sciences
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku
Article
Multidisciplinary Sciences
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku
Summary: Glioblastoma (GBM) is a deadly intracranial tumor. Sequencing technologies have helped in personalized therapy for GBM, but in vitro and in vivo models are needed to validate in silico evaluations of genomic features. GBM cell lines with whole exome sequencing (WES) datasets of matched tumor tissues and blood can be used to investigate molecular markers and validate druggable targets. A complete WES dataset of 26 GBM patient-derived cell lines along with their matched tumor tissues and blood is provided to show that cell lines can largely recapitulate genomic profiles of original tumors.
Article
Biochemistry & Molecular Biology
Hyeongsun Jeong, Hyo Eun Moon, Seongmin Yun, Seung Woo Cho, Hye Ran Park, Sung-Hye Park, Kyungjae Myung, Taejoon Kwon, Sun Ha Paek
Summary: In this study, 13 PDX models derived from 11 brain tumor patients were established. It was found that PDX samples were enriched with brain tumor-related genes and had distinct mutation profiles compared to the original tumors, indicating mutational alterations occurring in the xenograft environment.
Article
Engineering, Biomedical
Yun-Sik Dho, Byeong Cheol Lee, Hyeong Cheol Moon, Kyung Min Kim, Ho Kang, Eun Jung Lee, Min-Sung Kim, Jin Wook Kim, Yong Hwy Kim, Sang Joon Park, Chul-Kee Park
Summary: Concomitant with advances in computing technology, augmented reality-based navigation in clinical applications is being researched. Novel object tracking and depth realization technologies were developed for augmented reality-based neuronavigation in brain surgery. The results validate the efficacy of these technologies in overcoming critical obstacles in the development of clinically applicable augmented reality neuronavigation.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Review
Clinical Neurology
Chul-Kee Park, Jong Hee Chang
Summary: Recent updates in genomic-integrated glioma classification have caused confusion in clinical practice, but the Korean Brain Tumor Society conducted a questionnaire survey to gain consensus on risk group categorization and treatment preferences. They found agreement on dichotomic definition of risk groups and consistent decisions based on WHO grade and risk group for treatment protocols. Temporary consensus and available options will aid management until more evidence is accumulated under the new classification system.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Mi Kyoung Song, Sang Yoon Lee, Soon Ho Yoon, Jeong-Wook Seo
Summary: This study investigated the clinical value of patient-specific 3D models in multidisciplinary discussions for patients with complex congenital heart defects (CHDs). The results showed that the use of 3D-printed models improved the understanding of the disease, facilitated multidisciplinary discussions, and enhanced surgical decision-making.
JOURNAL OF CARDIAC SURGERY
(2023)
Review
Medicine, General & Internal
Jin Woo Park, Kwanghoon Lee, Eric Eunshik Kim, Seong-Ik Kim, Sung-Hye Park
Summary: The methylation classifier is a tool used to accurately classify brain tumors based on their methylation profiles. It helps healthcare professionals predict tumor prognosis and establish personalized treatment plans. However, it has limitations in classifying all types of brain tumors and faces challenges in obtaining reference data and charging patients for its services.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
