Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Medicine, Research & Experimental
Saumya Choudhary, Rishika Anand, Dibyabhaba Pradhan, Banajit Bastia, Shashi Nandar Kumar, Harpreet Singh, Poonam Puri, George Thomas, Arun Kumar Jain
Summary: This study utilized bioinformatics to analyze gene expression data of mild and severe psoriasis patients, revealing numerous differentially expressed genes and identifying important hub genes. The results indicate significant differences in gene expression regulation and signaling pathways between patients with different disease severity levels of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
M. A. X. Tollenaere, J. Hebsgaard, D. A. Ewald, P. Lovato, S. Garcet, X. Li, S. D. Pilger, M. L. Tiirikainen, M. Bertelsen, J. G. Krueger, H. Norsgaard
Summary: Multiple IL-17 ligands signaling through IL-17RA are overexpressed in psoriasis skin, inducing similar inflammatory pathways related to the disease. Brodalumab, as opposed to ixekizumab, can normalize gene expression responses induced by the combination of IL-17A, IL-17F, IL-17A/F, and IL-17C in human keratinocytes.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yanpeng Li, Zhilei Li, Kutty Selva Nandakumar, Rikard Holmdahl
Summary: A recent study found that a single nucleotide variant (NCF1(R90H)) on the NCF1 gene was associated with low production of reactive oxygen species (ROS) and causative for several autoimmune diseases. The study induced psoriasis in the skin and psoriatic arthritis using mannan and evaluated the effects. It was found that the NCF1(90H) variant promoted psoriasis and psoriatic arthritis by hyperactivating macrophages, expanding keratinocytes, and increasing numbers of γδT17 cells.
Article
Immunology
Jaehwan Kim, Jongmi Lee, Xuan Li, Norma Kunjravia, Darshna Rambhia, Inna Cueto, Katherine Kim, Vasuma Chaparala, Younhee Ko, Sandra Garcet, Wei Zhou, Junyue Cao, James G. Krueger
Summary: This study provides translational evidence that systemic IL-17A blockade promotes regulatory gene expression in immune cell subsets in human psoriasis skin, indicating its potential as a therapeutic approach for psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yulin Zou, Zudong Meng
Summary: Studies have shown that IL-17 inhibitors play a key role in alleviating or preventing cytokine storms in COVID-19 patients, while also helping to better understand the effects of drugs on the immune system.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Yoan Eliasse, Edouard Leveque, Lucile Garidou, Louise Battut, Brienne McKenzie, Therese Nocera, Daniel Redoules, Eric Espinosa
Summary: Acne is a multifactorial disease driven by physiological changes in the pilosebaceous unit during puberty. Mast cells are shown to be the main IL-17 producers in the early stages of acne, highlighting the importance of targeting the IL-17(+) mast cell/T helper cell axis in therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kie Mizumaki, Motoki Horii, Miyu Kano, Akito Komuro, Takashi Matsushita
Summary: This study found that increased regulatory B cells in mice can suppress IL-23-mediated psoriasis-like inflammation by expanding regulatory T cells and inhibiting Th17 cell differentiation, making them a potential strategy for treating psoriasis.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara
Summary: IL-33 and IL-37 co-regulate the balance between inflammation and anti-inflammation, and are involved in the pathogenesis of inflammatory skin diseases such as AD and psoriasis. AHR-mediated regulation of their expression may offer new therapeutic strategies for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Rakesh Pandey, Yusur Al-Nuaimi, Rajiv Kumar Mishra, Sarah K. Spurgeon, Marc Goodfellow
Summary: Psoriasis is a chronic inflammatory skin disease associated with a complex signaling network involving cytokines, immune cells, and skin cells.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Weiwei Guo, Fengying Xu, Zhuochen Zhuang, Zhe Liu, Jiming Xie, Liping Bai
Summary: The novel exopolysaccharide Ebosin shows promising anti-inflammatory effects in a psoriasis-like model, regulating inflammation through multiple pathways and enhancing the percentage of regulatory T cells, while reducing the number of inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Statistics & Probability
Camila Epprecht, Dominique Guegan, Alvaro Veiga, Joel Correa da Rosa
Summary: This article compares two approaches of model selection methods for linear regression models: the classical approach Autometrics and the statistical learning methods LASSO and adaLASSO. Through simulation experiments and application with genomic data, the performance of these methods under different scenarios are evaluated.
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2021)
Article
Hematology
Moonjung Jung, Parinda A. Mehta, Caroline S. Jiang, Rasim O. Rosti, Gabriel Usleaman, Joel M. Correa da Rosa, Francis P. Lach, Erica Goodridge, Arleen D. Auerbach, Stella M. Davies, Agata Smogorzewska, Farid Boulad
Summary: Among siblings with Fanconi anaemia, there is significant correlation in hematological progression, while constitutional abnormalities do not show strong concordance except for kidney abnormalities and microcephaly.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dunstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Summary: This study describes a selective non-steroidal glucocorticoid receptor (GR) agonist, LEO 134310, for topical use, which is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic index compared with currently used glucocorticoids. The selectivity of LEO 134310 for GR was confirmed within a panel of nuclear receptors, and topical treatment with LEO 134310 in minipigs did not result in significant epidermal thinning.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Yael Renert-Yuval, Joel Correa da Rosa, Sandra Garcet, Ana B. Pavel, Jennifer Bares, Margot Chima, Jason E. Hawkes, Patricia Gilleaudeau, Mary Sullivan-Whalen, Giselle K. Singer, James G. Krueger, Emma Guttman-Yassky
Summary: This study investigated the utility of two different alopecia areata-targeted questionnaires, and found that the Alopecia Areata Symptom Impact Scale (AASIS) correlated strongly with alopecia areata severity and clinical response. Patients with <= 20% scalp hair loss after treatment reported improvement in multiple quality-of-life items, which may guide clinicians and improve the development of future clinical trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tu Hu, Tanja Todberg, Daniel Andersen, Niels Banhos Danneskiold-Samsoe, Sofie Boesgaard Neestrup Hansen, Karsten Kristiansen, David Adrian Ewald, Susanne Brix, Joel Correa da Rosa, Ilka Hoof, Lone Skov, Thomas Litman
Summary: This study used BRB-seq technique to analyze the transcriptome of tape-stripped skin samples from atopic dermatitis patients and healthy controls. An AD signature consisting of genes related to skin barrier and inflammatory response was identified. However, the low and highly variable transcript counts in tape-stripped samples were a limiting factor for epidermal transcriptome profiling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Jaehwan Kim, Jongmi Lee, Jason E. Hawkes, Xuan Li, Norma Kunjravia, Darshna Rambhia, Inna Cueto, Ariana Moreno, Hong Hur, Sandra Garcet, Wei Zhou, Junyue Cao, James G. Krueger
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Cell Biology
Jaehwan Kim
WOUND REPAIR AND REGENERATION
(2022)
Letter
Dermatology
Jill I. Olydam, Linde E. M. de Wijs, Willem A. Dik, Mads A. Ropke, Joel Correa Da Rosa, Dirk Jan Hijnen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Joseph Han, Scott Stratman, Jade N. Young, Dina Poplausky, Shayan Owji, Yen Luu, Yeriel Estrada, Joel Correa da Rosa, James G. Krueger, Nicholas Gulati
Summary: Diphencyprone (DPCP) causes a delayed-type hypersensitivity reaction when applied topically, and is used clinically for various conditions. In this study, proteomic analysis of healthy volunteers showed upregulation of immune cell activation, tissue remodeling, antineoplastic markers, and Th1 axis markers following DPCP application. Negative regulators of immune function were also upregulated, which may explain the therapeutic benefits in autoimmune conditions. The study also revealed a transient Th2 response followed by Th1 polarization. Overall, DPCP induces a complex and evolving immunological response.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Tu Hu, Tanja Todberg, David Adrian Ewald, Ilka Hoof, Joel Correa da Rosa, Lone Skov, Thomas Litman
Summary: The skin transcriptome of atopic dermatitis (AD) is stable over time, with the largest variation due to disease, individual, and skin site. AD-specific differentially expressed genes revealed disrupted skin barrier and activated immune response as the main features of AD. Potential novel targets in AD were also identified. This study provides new methods and insights for future skin research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Allergy
Paola Facheris, Joel Correa Da Rosa, Angel D. D. Pagan, Michael Angelov, Ester Del Duca, Grace Rabinowitz, Pedro Jesus Gomez Arias, Camille Rothenberg Lausell, Yeriel D. D. Estrada, Swaroop Bose, Mashkura Chowdhury, Avner Shemer, Ana B. B. Pavel, Emma Guttman-Yassky
Summary: The unique characteristics of adult-onset atopic dermatitis (AOAD) compared to pediatric-onset AD persisting into adulthood (POAD) have not been well-studied, hindering the development of targeted therapeutics. This study analyzed skin and blood samples from AOAD, POAD, and healthy controls and found that both AOAD and POAD showed immune and barrier dysregulations with shared Th2/Th22 hyperactivation. POAD had greater inflammation and compromised epidermal barrier compared to AOAD. AOAD also had more dysregulated proteins in serum, including pro-inflammatory and cardiovascular-risk markers.
Article
Allergy
Jaehwan Kim, Jongmi Lee, Xuan Li, Hyun Soo Lee, Katherine Kim, Vasuma Chaparala, William Murphy, Wei Zhou, Junyue Cao, Michelle A. Lowes, James G. Krueger
Summary: This study characterized the transcriptome of HS T17 cells compared to psoriasis T17 cells and investigated their interactions with immune cell subsets. The results indicate that IL-1 beta-T17 cell cytokine axis is likely a dominant pathway in HS, and the interaction between semimature dendritic cells and T17 cells is increased in HS compared to psoriasis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Dermatology
Christine Suh-Yun Joh, Soyoung Jeong, Cheol Lee, Hee Jung Lee, Jung Ho Lee, Hyun Seung Choi, Soyun Cho, Gwangil Kim, Jaehwan Kim, James G. Krueger, Chung-Gyu Park, Jung U. Shin, Seon-Pil Jin, Hyun Je Kim
Summary: We examined the role of epithelium in early-stage HS by analyzing the profiles of epithelial cells and dermal-infiltrating immune cells. Compared to epidermal cysts, early-stage HS nodules showed upregulation of genes related to bacterial response, inflammatory mediators, and neutrophil degranulation pathways in epithelial cells. Analysis of dermal-infiltrating immune cells surrounding the nodules revealed elevated levels of B-cell-related genes. Our findings suggest that the production of inflammatory mediators in early-stage HS involves the activation of keratinocytes and their interaction with dermal-infiltrating immune cells, similar to sinus tract formation observed in moderate-to-severe HS.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Joel Correa da Rosa, Jose O. Aleman, Jason Mohabir, Yupu Liang, Jan L. Breslow, Peter R. Holt
Summary: Obesity is a growing epidemic in the United States, and there is limited understanding of the mechanisms behind weight gain and loss. Integrating omics data has become a popular method to increase understanding of complex phenotypes. The study developed a strategy to screen predictors from a small cohort of obese women, and successfully identified baseline fecal bile acids and regulation in RT-polymerase chain reaction as the most predictive data sources for forecasting weight loss rates.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Christina Pressl, Caroline S. Jiang, Joel Correa da Rosa, Maximilian Friedrich, Roger Vaughan, Winrich A. Freiwald, Jonathan N. Tobin
Summary: The study found a diagnostic rate for prosopagnosia of 0.012% (12 per 100,000 individuals). Elevated frequency of prosopagnosia diagnosis was observed in individuals with certain comorbid conditions such as personality disorder, depression, epilepsy, and anxiety. Furthermore, prosopagnosia diagnoses increased with the number of comorbid conditions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)