Review
Biochemistry & Molecular Biology
Dong Hoon Park, Joo Wan Kim, Hi-Joon Park, Dae-Hyun Hahm
Summary: Atopic dermatitis is a refractory and relapsing skin disease with a complex etiology involving congenital malformations and environmental factors. Recent advances in research on gut-skin connections have provided new insights for the treatment of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Alexis Rapin, Eva Maria Rehbinder, Matthew Macowan, Celine Pattaroni, Karin C. Lodrup Carlsen, Nicola L. Harris, Christine M. Jonassen, Linn Landro, Astrid H. Lossius, Bjorn Nordlund, Knut Rudi, Havard O. Skjerven, Anne Cathrine Staff, Cilla Soderhall, Niki Ubags, Riyas Vettukattil, Benjamin J. Marsland
Summary: Early-life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. This study assessed the association between the skin microbiome and AD, skin barrier integrity, and allergic diseases in the first year of life. It found that the composition of the skin microbiome is influenced by age, delivery mode, and other factors, and is associated with skin barrier integrity and the onset of AD.
Article
Microbiology
Caroline Meyer Olesen, Anna Cacilia Ingham, Simon Francis Thomsen, Maja-Lisa Clausen, Paal Skytt Andersen, Sofie Marie Edslev, Yasemin Topal Yuksel, Emma Guttman-Yassky, Tove Agner
Summary: The study found that treatment with dupilumab led to significant changes in the skin microbiome of AD patients, with a decrease in Staphylococcus aureus and an increase in Staphylococcus epidermidis and Staphylococcus hominis. Clinical symptoms improved significantly, suggesting a beneficial role of commensal staphylococci in AD.
Article
Immunology
Veda D. Khadka, Felix M. Key, Carolina Romo-Gonzalez, Adrian Martinez-Gayosso, Blanca L. Campos-Cabrera, Armando Geronimo-Gallegos, Tucker C. Lynn, Carola Duran-McKinster, Rafael Coria-Jimenez, Tami D. Lieberman, Maria T. Garcia-Romero
Summary: Patients with atopic dermatitis have high levels of Staphylococcus aureus in their skin microbiome, which decrease with treatment. The addition of dilute bleach baths significantly reduces S. aureus burden and could be a therapeutic option for AD patients. Further research in double-blinded trials is needed to confirm these findings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Danuta Nowicka, Karolina Chilicka, Iwona Dziendziora-Urbinska
Summary: Atopic dermatitis is a complex and unclear disease, with possible causes including changes in the skin barrier, disruptions in the skin microbiome, immune factors, allergens, infections, and environmental and genetic factors. Mechanisms promoting skin colonization by pathogens in atopic skin involve interactions between various factors. Understanding the factors involved in bacterial and fungal colonization in atopic dermatitis can provide insights for treatment and prevention.
Article
Veterinary Sciences
Ju-Yong Park, Seon-Myeong Kim, Jung-Hyun Kim
Summary: The study found that phototherapy using a 308-nm excimer light significantly changed the skin microbiome composition, alleviated clinical symptoms, and improved skin barrier function in dogs with atopic dermatitis. It also increased microbial diversity.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, General & Internal
Rachel L. Sadowsky, Pranvera Sulejmani, Peter A. Lio
Summary: Atopic dermatitis (AD) is a common, chronic and recurring inflammatory skin disorder. The etiology of AD involves environmental, genetic, and immunologic factors. The gut microbiome, which plays a role in maintaining the homeostasis of several organ systems, has been suggested to have a role in AD pathogenesis but studies have shown conflicting evidence. This review discusses recent insights into the role of the gut microbiome in AD pathogenesis and its interplay among other complex systems that govern the current assessments of and treatments for AD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Rie Dybboe Bjerre, Jacob Bak Holm, Albert Palleja, Julie Solberg, Lone Skov, Jeanne Duus Johansen
Summary: This study highlights significant differences in microbial composition between patients with atopic dermatitis (AD) and healthy controls at different skin sites, with the most pronounced differences observed on the flexures and neck. The neck of AD patients lacks certain microbial species, and viruses mainly consist of Propionibacterium and Staphylococcus phages.
Article
Allergy
Angeline S. L. Tay, Chenhao Li, Tannistha Nandi, Kern Rei Chng, Anand Kumar Andiappan, Vijaya Saradhi Mettu, Camille de Cevins, Aarthi Ravikrishnan, Charles-Antoine Dutertre, X. F. Colin C. Wong, Amanda Hui Qi Ng, Sri Anusha Matta, Florent Ginhoux, Olaf Rotzschke, Fook Tim Chew, Mark B. Y. Tang, Yik Weng Yew, Niranjan Nagarajan, John E. A. Common
Summary: Different microbial profiles on AD skin were identified, with dermotype B showing reduced microbial richness, depletion of certain species, individual-specific outlier abundance of Staphylococcus species, and enrichment in metabolic pathways and virulence genes. These microbial configurations were associated with more severe itching, frequent flares, and increased disease severity in patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Leszek Blicharz, Lidia Rudnicka, Joanna Czuwara, Anna Waskiel-Burnat, Mohamad Goldust, Malgorzata Olszewska, Zbigniew Samochocki
Summary: Atopic dermatitis is a common inflammatory skin disease caused by epidermal barrier defects leading to immune dysregulation. Recent research has shown that skin microbiota and bacterial biofilms have a negative impact on skin barrier function, contributing to the onset and exacerbation of atopic dermatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Manuela Machado, Sara Silva, Eduardo M. Costa
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is caused by various factors and leads to skin barrier dysfunction. It results in highly pruritic skin lesions, dry skin, and comorbidities including skin infections. The use of antimicrobial peptides (AMPs) has emerged as a promising alternative solution for managing AD by modulating the skin microbiome, fighting infections, and balancing immune response. However, there are limitations in the production and use of AMPs. This study aims to compile available information and provide a better understanding of the true potential of AMPs in addressing AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Jocelyn M. Biagini, John W. Kroner, Asel Baatyrbek Kyzy, Alexandra Gonzales, Hua He, Mariana Stevens, Brittany Grashel, Daniel Spagna, Samuel Paul, Rahul Patel, Angelo Bucci, Michael G. Sherenian, Liza Bronner Murrison, Lisa J. Martin, Gurjit K. Khurana Hershey
Summary: This study investigates the atopic march in Black and White children and identifies distinct allergic trajectories in these populations. It reveals that Black children have a higher risk of asthma despite a more intact skin barrier and less sensitization, food allergy, and allergic rhinitis. Conversely, White children have a lower risk of asthma despite a more dysfunctional skin barrier and higher rates of sensitization, food allergy, and allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Aaroh Anand Joshi, Marc Vocanson, Jean-Francois Nicolas, Peter Wolf, Vijaykumar Patra
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. Disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components of AD pathogenesis. Decreased expression of AMPs in AD patients leads to increased colonization by Staphylococcus aureus. AMPs derived from the host and skin microbiome play a crucial role in defining the skin microbial landscape and maintaining immune homeostasis, making them potential therapeutics for AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Oki Suwarsa, Maryam Nissa Hazari, Hartati Purbo Dharmadji, Reiva Farah Dwiyana, Raden Mohamad Rendy Ariezal Effendi, Risa Miliawati Nurul Hidayah, Erda Avriyanti, Hendra Gunawan, Endang Sutedja
Summary: This study analyzed the skin microbiome composition and diversity in Indonesian AD patients. The results showed that Firmicutes were dominant in moderate AD, while Proteobacteria were dominant in mild AD. Microbial diversity was lower in moderate AD.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Xinhua Liu, Youteng Qin, Liyun Dong, Ziyi Han, Tianning Liu, Ying Tang, Yun Yu, Jingjie Ye, Juan Tao, Xuan Zeng, Jun Feng, Xian-Zheng Zhang
Summary: This study developed a living bacterial formulation integrated into a skin dressing to treat skin diseases with dysbiosis of skin microbiota, such as atopic dermatitis. The dressing not only provides a favorable environment for the survival of symbiotic bacteria, but also accelerates wound healing, restores abnormal skin characteristics, and alleviates immune/inflammation responses associated with atopic dermatitis.
BIOACTIVE MATERIALS
(2023)
Article
Microbiology
S-M Frosini, R. Bond, M. Rantala, T. Gronthal, S. C. Rankin, K. O'Shea, D. Timofte, V. Schmidt, J. Lindsay, A. Loeffler
Article
Orthopedics
James Peter Beck, Max Grogan, Brian T. Bennett, Sujee Jeyapalina, Jay Agarwal, Casey Bartow-McKenney, Julia Bugayev, Erik Kubiak, Sarina Sinclair, Elizabeth Grice
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Dermatology
Charles W. Bradley, Fiona F. Lee, Shelley C. Rankin, Lindsay R. Kalan, Joseph Horwinski, Daniel O. Morris, Elizabeth A. Grice, Christine L. Cain
VETERINARY DERMATOLOGY
(2020)
Article
Veterinary Sciences
Laurel Redding, Haley Grunwald, Stephen Cole, Shelley Rankin, Rose Nolen-Walston
Article
Pharmacology & Pharmacy
Joseph M. Blondeau, Shelley C. Rankin
Summary: Technological advancements have revolutionized the way clinical microbiology laboratories detect and identify pathogens, improving sensitivity, specificity, and reducing reporting turnaround time. This article reviews traditional methodologies and technological innovations in diagnostic microbiology laboratories, as well as providing insights into future developments.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Microbiology
Gregory H. Tyson, Olgica Ceric, Jake Guag, Sarah Nemser, Stacey Borenstein, Durda Slavic, Sarah Lippert, Rebecca McDowell, Aparna Krishnamurthy, Shannon Korosec, Cheryl Friday, Neil Pople, Matthew E. Saab, Julie-Helene Fairbrother, Isabelle Janelle, Deanna McMillan, Yugendar R. Bommineni, David Simon, Shipra Mohan, Susan Sanchez, Ashley Phillips, Paula Bartlett, Hemant Naikare, Cynthia Watson, Orhan Sahin, Chloe Stinman, Leyi Wang, Carol Maddox, Vanessa DeShambo, Kenitra Hendrix, Debra Lubelski, Amy Burklund, Brian Lubbers, Debbie Reed, Tracie Jenkins, Erdal Erol, Mukeshbhai Patel, Stephan Locke, Jordan Fortner, Laura Peak, Udeni Balasuriya, Rinosh Mani, Niesa Kettler, Karen Olsen, Shuping Zhang, Zhenyu Shen, Martha Pulido Landinez, Jay Kay Thornton, Anil Thachil, Melissa Byrd, Megan Jacob, Darlene Krogh, Brett Webb, Lynn Schaan, Amar Patil, Sarmila Dasgupta, Shannon Mann, Laura B. Goodman, Rebecca June Franklin-Guild, Renee R. Anderson, Patrick K. Mitchell, Missy Aprea, Brittany D. Cronk, Jing Cui, Dominika Jurkovic, Melanie Prarat, Yan Zhang, Katherine Shiplett, Dubra Diaz Campos, Joany Van Balen Rubio, Akhilesh Ramanchandran, Scott Talent, Deepanker Tewari, Nagaraja Thirumalapura, Donna Kelly, Denise Barnhart, Lacey Hall, Shelley Rankin, Jaclyn Dietrich, Stephen Cole, Joy Scaria, Linto Antony, Sara D. Lawhon, Jing Wu, Christine McCoy, Kelly Dietz, Rebecca Wolking, Trevor Alexander, Claire Burbick, Renate Reimschuessel
Summary: This study evaluated the correlation between resistance genotypes and phenotypes for Staphylococcus pseudintermedius by conducting antimicrobial susceptibility testing and WGS on isolates collected from dogs in the United States. The results showed a strong correlation between resistance genotypes and clinical resistance phenotypes, with findings comparable to studies on human pathogens such as Staphylococcus aureus and Salmonella enterica. Notable discoveries included the presence of mecA gene in 32.3% of isolates, which correlated with oxacillin resistance 97.0% of the time, and the identification of a novel rpoB mutation likely encoding rifampin resistance. The study highlights the value of using WGS to assess antimicrobial resistance in veterinary pathogens and uncover potential new mechanisms of resistance.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Tej Pratap Singh, Augusto M. Carvalho, Lais Amorim Sacramento, Elizabeth A. Grice, Phillip Scott
Summary: This study demonstrates the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. Skin microbiota promotes the generation of ROR gamma t(+) IL-17A-producing ILCs, which exacerbate skin inflammation in the disease.
Review
Multidisciplinary Sciences
Tamia A. Harris-Tryon, Elizabeth A. Grice
Summary: The human skin acts as a protective barrier and plays a crucial role in our overall health. The microbiota colonization on the skin plays a significant role in maintaining the skin's barrier function and protecting against pathogens. Understanding the host-microbiota interactions can provide insights into the development and management of skin disorders.
Review
Dermatology
Heather Woolery-Lloyd, Anneke Andriessen, Doris Day, Noelani Gonzalez, Lawrence Green, Elizabeth Grice, Michelle Henry
Summary: This review explores the relationship between the skin microbiome and facial skin aging, and the effects of oral and topical use of probiotics, prebiotics, and postbiotics on skin aging and cosmetic outcomes. The study suggests that a diverse skin microbiome is essential for skin health, and preliminary evidence indicates that oral probiotics and prebiotics may reduce signs of skin aging by increasing microbiome diversity. Additionally, the application of topically applied probiotics, prebiotics, and postbiotics may improve skin aging signs such as fine lines and hydration. Larger studies are needed to further understand the role of the microbiome in skin aging and the potential benefits of probiotics, prebiotics, and postbiotics use.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Alina D. Schmidt, Charlene Miciano, Qi Zheng, Mary Elizabeth Mathyer, Elizabeth A. Grice, Cristina de Guzman Strong
Summary: Increased IVL expression shows positive selection and plays a role in regulating VDR activity, affecting skin inflammation and microbiota stability in the epidermis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Carrie Hayes Sutter, Shafquat Azim, Anyou Wang, Jyoti Bhuju, Amelia S. Simpson, Aayushi Uberoi, Elizabeth A. Grice, Thomas R. Sutter
Summary: Activation of the aryl hydrocarbon receptor (AHR) promotes keratinocyte differentiation and the formation of the epidermal permeability barrier. Lipids, including ceramides, play a critical role in the epidermal permeability barrier. Researchers found that AHR ligand increased the RNA levels of ceramide metabolism and transport genes in human epidermal keratinocytes, as well as the levels of skin ceramides. They identified UGCG as a direct target of AHR and demonstrated that AHR regulates the expression of UGCG, an enzyme involved in ceramide trafficking, keratinocyte differentiation, and epidermal permeability barrier formation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Tej Pratap Singh, Camila Farias Amorim, Victoria M. Lovins, Charles W. Bradley, Lucas P. Carvalho, Edgar M. Carvalho, Elizabeth A. Grice, Phillip Scott
Summary: Cutaneous leishmaniasis leads to changes in the skin microbiota, resulting in immune responses and delayed healing. This study demonstrates that depletion of regulatory T cells contributes to skin inflammation and impaired immunity against Staphylococcus aureus in mice. Similar findings are observed in Leishmania braziliensis-infected mice and patients, suggesting a critical role of these cells in regulating immune balance and disease progression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Microbiology
Monica Wei, Simon A. B. Knight, Laurice Flowers, Jasmine Walsh, Elizabeth Grice
Summary: It has been previously shown that Desemzia incerta isolated from porcine skin exhibits antimicrobial activity against methicillin-resistant Staphylococcus aureus. In this study, the complete genome of D. incerta, consisting of one circular chromosome and five circular plasmids, is presented.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Letter
Immunology
Stephen D. Cole, Laura Peak, Gregory H. Tyson, Renate Reimschuessel, Olgica Ceric, Shelley C. Rankin
EMERGING INFECTIOUS DISEASES
(2020)
Article
Microbiology
Gregory H. Tyson, Cong Li, Olgica Ceric, Renate Reimschuessel, Stephen Cole, Laura Peak, Shelley C. Rankin
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)