Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Johanna Rankenberg, Stefan Rakete, Brandie D. Wagner, Jennifer L. Patnaik, Christian Henning, Anne Lynch, Marcus A. Glomb, Ram H. Nagaraj
Summary: The levels of AGEs in human lens capsules during cataract surgery were found to be similar between diabetic and non-diabetic patients, except for significantly higher levels of glucosepane in diabetic patients, which may explain the similar incidence of posterior capsule opacification between the two groups.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Shazia Qayyum, Muhammad Afzal, Abdul Khaliq Naveed
Summary: The study suggests that the 374T/A (rs1800624) polymorphism may be associated with Type-2 diabetes mellitus and diabetic retinopathy in Pakistani patients. The heterozygous TA genotype and mutant A allele may play a role in the development of the diseases.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Yu Peng, Fubin Liu, Yating Qiao, Peng Wang, Han Du, Changyu Si, Xixuan Wang, Kexin Chen, Fangfang Song
Summary: This study found that higher levels of plasma AGEs and AGEs/sRAGE-ratio were associated with an increased risk of breast cancer, but sRAGE levels were negatively associated with breast cancer risk. The study emphasized the potential of the AGE-RAGE axis as a new biomarker of breast cancer.
Article
Agriculture, Multidisciplinary
Hong Sun, Juan Chen, Lili Sun, Bimin Shi, Jianzhong Li
Summary: Research found that silencing TXNIP can reduce renal lipid deposition, inhibit cholesterol uptake and synthesis through regulating SCAP, and may be a potential therapeutic target for treating a diabetic fatty kidney.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Lingwen Ying, Yun Shen, Yang Zhang, Yikun Wang, Yong Liu, Jun Yin, Yufei Wang, Jingrong Yin, Wei Zhu, Yuqian Bao, Jian Zhou
Summary: This study found a positive association between AGEs levels and diabetic retinopathy (DR), with higher AGEs associated with more severe DR. The predictive value of AGEs for DR was similar to that of glycated hemoglobin A(1c) (HbA(1c), but AGEs showed higher efficacy in early screening for vision-threatening DR (VTDR). Non-invasive measurement of skin AGEs may be a more suitable indicator for poor prognosis of hyperglycemia compared to HbA(1c).
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Liu Gao, Chang Liu, Pan Hu, Na Wang, Xiaoxue Bao, Bin Wang, Ke Wang, Yukun Li, Peng Xue
Summary: The objective of this study was to analyze the quantitative association between advanced glycation end products (AGEs) and adjusted FRAX by rheumatoid arthritis (FRAX-RA) in postmenopausal type 2 diabetic (T2D) patients. The optimal cutoff value of AGEs was also explored, which was aimed at demonstrating the potential value of AGEs on evaluating osteoporotic fracture risk in postmenopausal T2D patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Health Care Sciences & Services
Alejandra Planas, Olga Simo-Servat, Cristina Hernandez, Angel Ortiz-Zuniga, Joan Ramon Marsal, Jose R. Herance, Ignacio Ferreira-Gonzalez, Rafael Simo
Summary: This study aimed to evaluate whether diabetic retinopathy and accumulation of advanced glycation end-products can help identify high-risk cardiovascular events in patients with type 2 diabetes, and found that these factors were independent predictors of cardiovascular events. It is suggested that using these factors to screen patients for cardiovascular disease could lead to more personalized and cost-effective medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Shazia Qayyum, Muhammad Afzal, Abdul Khaliq Naveed
Summary: The study revealed an association between the 429T/C receptor for advanced glycation end products gene polymorphism and the severity of diabetic retinopathy, while serum soluble receptor for advanced glycation end products levels were positively correlated with the severity of diabetic retinopathy.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2021)
Article
Cell Biology
Haoqiang Zhang, Yafen Chu, Hongwei Zheng, Jing Wang, Bing Song, Yao Sun
Summary: The study showed that cognitive function in diabetic mice was improved by liraglutide through down-regulating RAGE.
Article
Endocrinology & Metabolism
Xue-Meng Zhang, Yuan Gao, Meng-Xue Yang, Xiao-Di Zheng, Rui Zhang, Yue-Yue Wu, Miao Zeng, Qian Yang, Zhi-Yan Yu, Jun Liu, Bing-Bing Zha, Bo Yang
Summary: Diabetic kidney disease (DKD) is a complication of diabetes, and early detection is crucial. This study found that the noninvasive lens AGEs fluorescence detection method can be used to predict the occurrence of DKD, providing clinical value in diagnosing DKD in patients with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Review
Biochemistry & Molecular Biology
Klaudia Gutowska, Krzysztof Czajkowski, Alina Kurylowicz
Summary: Advanced glycation end products (AGEs) play a crucial role in cellular dysfunction caused by hyperglycemia, and their accumulation in the extracellular matrix is a key factor in obesity-related adipose tissue dysfunction. By binding to their receptor (RAGE), AGEs affect various intracellular pathways, leading to impaired adipocyte differentiation, metabolism, and secretory activity. Inhibiting AGE production and accumulation, as well as interfering with the activated metabolic pathways, may be a promising therapeutic strategy for restoring normal adipose tissue function and combating obesity-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yun-Liang Tang, Jiao Yu, Zhen-Guo Zeng, Ying Liu, Jian-Ying Liu, Ji-Xiong Xu
GYNECOLOGICAL ENDOCRINOLOGY
(2017)
Article
Peripheral Vascular Disease
Lingyan Zhu, Jixiong Xu, Ying Liu, Tian Gong, Jianying Liu, Qiong Huang, Shane Fischbach, Wenquan Zou, Xiangwei Xiao
Article
Biotechnology & Applied Microbiology
Ying Liu, Jian Cui, Yun-Liang Tang, Liang Huang, Cong-Yang Zhou, Ji-Xiong Xu
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Medicine, General & Internal
Sha Zeng, Hua-Xia Gan, Ji-Xiong Xu, Jian-Ying Liu
Article
Medicine, Research & Experimental
Qiong Huang, Qi Gong, Ting Wen, Shanshan Feng, Jixiong Xu, Jianying Liu, Xiudan Han, Qun Liu, Juan Hu, Lingyan Zhu
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Yunliang Tang, Jiao Wang, Wei Cai, Jixiong Xu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Oncology
Jiao Wang, Honghong Liu, Guijiao Xie, Wei Cai, Jixiong Xu
MOLECULAR MEDICINE REPORTS
(2020)
Review
Medicine, General & Internal
Yuanyuan Deng, Jiao Wang, Honghong Liu, Jianying Liu, Jixiong Xu
POSTGRADUATE MEDICINE
(2020)
Article
Food Science & Technology
Wei Cai, Jixiong Xu, Gang Li, Tao Liu, Xiali Guo, Huajie Wang, Liping Luo
FOOD RESEARCH INTERNATIONAL
(2020)
Review
Endocrinology & Metabolism
Jiao Wang, Jixiong Xu
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Medical Laboratory Technology
Jie Zhang, Zhaoxia Gong, Shanshan Li, Ping Fan, Guanru Yue, Guilin Zou, Shasha He, Jiao Wang, Jixiong Xu
Summary: The combination of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and thyroid imaging reporting and data system (TIRADS) may be a novel method for screening benign and malignant thyroid nodules. The NLR-K-TIRADS score of 2 was associated with a higher proportion of malignant nodules compared to scores of 1 and 0. NLR-K-TIRADS 2 showed higher specificity and positive predictive value for the diagnosis of malignant nodules compared to K-TIRADS grades >= 4a.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Endocrinology & Metabolism
Yuanyuan Deng, Jie Zhang, Guilin Zou, Shanshan Li, Zhaoxia Gong, Guanru Yue, Ping Fan, Jixiong Xu
Summary: This study demonstrates that peripheral blood SII, PLR, leukocyte count, and age are independent risk factors for malignant thyroid nodules. The combination of these factors can better predict benign and malignant thyroid nodules, providing guidance for diagnosis and treatment.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yuanyuan Deng, Jie Zhang, Jiao Wang, Jinying Wang, Junping Zhang, Lulu Guan, Shasha He, Xiudan Han, Wei Cai, Jixiong Xu
Summary: This study comprehensively evaluated the risk factors of lymph node metastasis in PTC based on preoperative clinical and imaging data and constructed a nomogram model to predict the risk of lymph node metastasis.
POSTGRADUATE MEDICINE
(2023)
Review
Endocrinology & Metabolism
Yun Zou, Shanshan Li, Wen Chen, Jixiong Xu
Summary: Researchers have found that urine-derived stem cells (USCs) can have therapeutic effects on diabetes mellitus (DM) and its complications through direct differentiation or paracrine mechanisms. USCs have the advantages of simple sample collection procedures and low cost, making them a promising candidate for regenerative therapies.
Article
Endocrinology & Metabolism
Yuanyuan Deng, Jiao Wang, Guilin Zou, Zelin Liu, Jixiong Xu
Summary: A small proportion of patients with GD have elevated serum IgG4/IgG levels. They are younger, have higher eosinophils, more prone to allergies, higher levels of cytokines IL-1 beta and IL-17, and less easily attain remission after treatment with ATD, possibly due to the instability of the Th17/Treg cell balance.