Bariatric surgery and type 2 diabetes: are there weight loss-independent therapeutic effects of upper gastrointestinal bypass?

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

(2016) Faidon Magkos et al.   Cell Metabolism

Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose

(2015) Faidon Magkos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion

(2015) Ele Ferrannini et al.   DIABETES

Preserved Insulin Secretory Capacity and Weight Loss Are the Predominant Predictors of Glycemic Control in Patients With Type 2 Diabetes Randomized to Roux-en-Y Gastric Bypass

(2015) Kim T. Nguyen et al.   DIABETES

Standards of Medical Care in Diabetes—2016: Summary of Revisions

(2015)   DIABETES CARE

Determinants of Diabetes Remission and Glycemic Control After Bariatric Surgery

(2015) Simona Panunzi et al.   DIABETES CARE

Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery

(2015) Jaakko Mäkinen et al.   DIABETOLOGIA

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity

(2015) B Rachid et al.   INTERNATIONAL JOURNAL OF OBESITY

Improvements in Glucose Metabolism Early After Gastric Bypass Surgery Are Not Explained by Increases in Total Bile Acids and Fibroblast Growth Factor 19 Concentrations

(2015) Nils B. Jørgensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preoperative β-cell function in patients with type 2 diabetes is important for the outcome of Roux-en-Y gastric bypass surgery

(2015) Michael Taulo Lund et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bariatric–metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial

(2015) Geltrude Mingrone et al.   LANCET

Adults with long-duration type 2 diabetes have blunted glycemic andβ-Cell function improvements after bariatric surgery

(2015) Vishesh Khanna et al.   Obesity

FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes

(2015) Saachi Sachdev et al.   OBESITY SURGERY

Individual bile acids have differential effects on bile acid signaling in mice

(2015) Peizhen Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Five-Year Outcomes After Laparoscopic Gastric Bypass and Laparoscopic Duodenal Switch in Patients With Body Mass Index of 50 to 60

(2015) Hilde Risstad et al.   JAMA Surgery

Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery

(2015) Jan Peter Yska et al.   JAMA Surgery

Bile acids, obesity, and the metabolic syndrome

(2014) Huijuan Ma et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes

(2014) A. Jimenez et al.   DIABETES

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

Association of Bariatric Surgery With Long-term Remission of Type 2 Diabetes and With Microvascular and Macrovascular Complications

(2014) Lars Sjöström et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes

(2014) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid gastric and intestinal transit is a major determinant of changes in blood glucose, intestinal hormones, glucose absorption and postprandial symptoms after gastric bypass

(2014) Nam Q. Nguyen et al.   Obesity

Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects

(2014) David Bradley et al.   Obesity

Impact of Different Criteria on Type 2 Diabetes Remission Rate After Bariatric Surgery

(2014) A. Mas-Lorenzo et al.   OBESITY SURGERY

Roux-en-Y Gastric Bypass Surgery or Lifestyle With Intensive Medical Management in Patients With Type 2 Diabetes

(2014) Florencia Halperin et al.   JAMA Surgery

Surgical vs Medical Treatments for Type 2 Diabetes Mellitus

(2014) Anita P. Courcoulas et al.   JAMA Surgery

Multidisciplinary diabetes care with and without bariatric surgery in overweight people: a randomised controlled trial

(2014) John M Wentworth et al.   Lancet Diabetes & Endocrinology

Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

(2013) Ling-Chun Kong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy

(2013) Adam P. Chambers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass

(2013) M. Shah et al.   DIABETES

Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes

(2013) Nils B. Jørgensen et al.   DIABETES

Limited Recovery of  -Cell Function After Gastric Bypass Despite Clinical Diabetes Remission

(2013) R. Dutia et al.   DIABETES

Very Low–Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and β-Cell Function in Type 2 Diabetic Patients

(2013) Clifton Jackness et al.   DIABETES

Metabolic Effects of Bariatric Surgery in Patients With Moderate Obesity and Type 2 Diabetes: Analysis of a randomized control trial comparing surgery with intensive medical treatment

(2013) S. R. Kashyap et al.   DIABETES CARE

The Prevalence of Meeting A1C, Blood Pressure, and LDL Goals Among People With Diabetes, 1988-2010

(2013) S. Stark Casagrande et al.   DIABETES CARE

Roux-en-Y Gastric Bypass vs Intensive Medical Management for the Control of Type 2 Diabetes, Hypertension, and Hyperlipidemia

(2013) Sayeed Ikramuddin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

(2013) Rohit Kohli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients

(2013) Heidi Immonen et al.   JOURNAL OF HEPATOLOGY

Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery

(2013) L. Sjöström   JOURNAL OF INTERNAL MEDICINE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

(2013) Janne Orava et al.   Obesity

Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial

(2013) Robert E. Steinert et al.   Obesity

Hypertrophy Dependent Doubling of L-Cells in Roux-en-Y Gastric Bypass Operated Rats

(2013) Carl Frederik Hansen et al.   PLoS One

Reprogramming of Intestinal Glucose Metabolism and Glycemic Control in Rats After Gastric Bypass

(2013) N. Saeidi et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance

(2012) N. B. Jørgensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Long-Term Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetes Mellitus in Morbidly Obese Subjects

(2012) Amanda Jiménez et al.   ANNALS OF SURGERY

Predicting the Glycemic Response to Gastric Bypass Surgery in Patients With Type 2 Diabetes

(2012) J. B. Dixon et al.   DIABETES CARE

Effects of Bariatric Surgery on Glucose Homeostasis and Type 2 Diabetes

(2012) David Bradley et al.   GASTROENTEROLOGY

Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

(2012) G. H. E. J. Vijgen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gastric bypass and banding equally improve insulin sensitivity and β cell function

(2012) David Bradley et al.   JOURNAL OF CLINICAL INVESTIGATION

Roux-en-Y gastric bypass surgery increases number but not density of CCK-, GLP-1-, 5-HT-, and neurotensin-expressing enteroendocrine cells in rats

(2012) M. B. Mumphrey et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

(2012) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes

(2012) Geltrude Mingrone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

(2012) M. Simonen et al.   OBESITY SURGERY

A Multisite Study of Long-term Remission and Relapse of Type 2 Diabetes Mellitus Following Gastric Bypass

(2012) David E. Arterburn et al.   OBESITY SURGERY

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

(2012) J Graessler et al.   PHARMACOGENOMICS JOURNAL

Type 2 diabetes after gastric bypass: remission in five models using HbA1c, fasting blood glucose, and medication status

(2012) Robin Blackstone et al.   Surgery for Obesity and Related Diseases

Predicting success of metabolic surgery: age, body mass index, C-peptide, and duration score

(2012) Wei-Jei Lee et al.   Surgery for Obesity and Related Diseases

Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders

(2011) D. J. Pournaras et al.   BRITISH JOURNAL OF SURGERY

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Hepatic and Peripheral Insulin Sensitivity and Diabetes Remission at 1 Month After Roux-en-Y Gastric Bypass Surgery in Patients Randomized to Omentectomy

(2011) J. P. Dunn et al.   DIABETES CARE

The Bile Acid Membrane Receptor TGR5: A Valuable Metabolic Target

(2011) Thijs W.H. Pols et al.   DIGESTIVE DISEASES

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized Clinical Trial of Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy for the Management of Patients with BMI 

(2011) Ioannis Kehagias et al.   OBESITY SURGERY

First-phase insulin secretion, insulin sensitivity, ghrelin, GLP-1, and PYY changes 72 h after sleeve gastrectomy in obese diabetic patients: the gastric hypothesis

(2011) N. Basso et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

The Importance of Caloric Restriction in the Early Improvements in Insulin Sensitivity After Roux-en-Y Gastric Bypass Surgery

(2010) J. M. Isbell et al.   DIABETES CARE

Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport

(2009) Adam T. Stearns et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Improvement in Glucose Metabolism After Bariatric Surgery: Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy

(2009) Ralph Peterli et al.   ANNALS OF SURGERY

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Postprandial Diabetic Glucose Tolerance Is Normalized by Gastric Bypass Feeding as Opposed to Gastric Feeding and Is Associated With Exaggerated GLP-1 Secretion: A case report

(2009) C. Dirksen et al.   DIABETES CARE

How Do We Define Cure of Diabetes?

(2009) J. B. Buse et al.   DIABETES CARE

Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

(2009) Erik Kirk et al.   GASTROENTEROLOGY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents

(2009) Arlette Santacruz et al.   Obesity

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Remission of type 2 diabetes after Roux-en-Y gastric bypass is associated with greater weight loss

(2009) Brian E. Kadera et al.   Surgery for Obesity and Related Diseases

Analysis of factors associated with durable remission of diabetes after Roux-en-Y gastric bypass

(2009) Silas M. Chikunguwo et al.   Surgery for Obesity and Related Diseases

Re-emergence of diabetes after gastric bypass in patients with mid- to long-term follow-up

(2009) Mary DiGiorgi et al.   Surgery for Obesity and Related Diseases

Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes

(2009) F. Abbatini et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes

(2008) Antonio Cervera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes

(2008) John B. Dixon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Weight Loss by Gastric Bypass SurgeryVersusHypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

(2008) Blandine Laferrère et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE