Article
Multidisciplinary Sciences
Soujanya S. Karanth, Shuofei Sun, Huanjing Bi, Kaiming Ye, Sha Jin
Summary: A newly discovered angiopoietin signal promotes the generation of mature islets from human induced pluripotent stem cells (iPSCs). The stimulated islets show enhanced glucose responsiveness and regulated insulin exocytosis through actin-filament polymerization and depolymerization. Angiopoietins act as signaling molecules to endorse in vitro islet development from iPSCs.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Maria del Mar Ferra-Canellas, Marta Munar-Bestard, Laura Garcia-Sureda, Beatrice Lejeune, Joana Maria Ramis, Marta Monjo
Summary: The study demonstrates that low-dose BMP4 MI treatment has anti-inflammatory and regenerative properties on gingival fibroblasts, and improves cell viability in 3D gingiva under inflammatory conditions.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Chemistry, Physical
Junhyung Kim, Seoyun Lee, Yonghyun Choi, Jonghoon Choi, Byung-Jae Kang
Summary: BMP-2 encapsulated alginate microbeads (AM) and VEGF-adsorbing Apt-HA were used to enhance bone regeneration, with AM showing sustained release of BMP-2. The combination of BMP-2-encapsulated Apt-HA + AM showed significantly improved bone regeneration.
Article
Biotechnology & Applied Microbiology
Hongwei Xu, Huanhuan Luo, Jiayu Chen, Gang Chen, Xiaohua Yu, Zhaoming Ye
Summary: In this study, a mineral-coated microparticle-hydrogel system is developed for the controlled release and optimized delivery of BMP-2, which shows significant therapeutic effects in treating large bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhang
Summary: The study successfully delivered celastrol using enzyme-responsive nanoparticles to induce apoptosis of OCs and macrophages in rheumatoid arthritis joints, reducing inflammation and showing therapeutic effects in a rat model.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Dean M. Cordingley, Stephen M. Cornish, Darren G. Candow
Summary: It is well established that creatine supplementation, especially when combined with resistance training, significantly increases muscle mass and strength. New research also suggests that creatine supplementation has positive effects on bone biology. Creatine influences cellular hydration, energy metabolism, growth factors, muscle protein kinetics, and bone remodeling. It also has anti-inflammatory and anti-catabolic properties, creating a favorable environment for muscle and bone development. Creatine supplementation can decrease inflammation markers and possibly slow down cancerous tumor growth. In terms of musculoskeletal health, creatine supplementation reduces muscle protein breakdown (especially in males) and bone resorption when combined with resistance training.
Article
Biochemistry & Molecular Biology
Yi-ding Zhang, Ao-bo Ma, Lu Sun, Jun-duo Chen, Guang Hong, Hong-kun Wu
Summary: This study explores an easy and sound way to modify the biological behavior of microspheres for bone tissue regeneration. Nanoclay can successfully sediment on the surface of microspheres, binding with either positively or negatively charged proteins. These properties facilitate cell proliferation and minimize the use of BMP-2.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Cell Biology
Cai-Ping Yan, Xing-Kuan Wang, Ke Jiang, Chong Yin, Chao Xiang, Yong Wang, Chaoyu Pu, Lu Chen, Yu-Ling Li
Summary: Bone defects are a global public health problem, and the available methods for inducing bone regeneration are limited. β-ecdysterone, a plant sterol similar to estrogen, has been found to promote bone regeneration by enhancing osteoblast differentiation and activating the BMP-2/Smad/Runx2/Osterix pathway. This study provides a new direction for osteogenic differentiation and offers novel therapeutic strategies for treating bone defects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Pharmacology & Pharmacy
Julius Sundermann, Steffen Sydow, Laura Burmeister, Andrea Hoffmann, Henning Menzel, Heike Bunjes
Summary: This study investigated the release performance of BMP-2 from PCL fiber mat-based implant prototypes coated with chitosan nanogel, highlighting the significant effects of chitosan and solubilizing additives on the recovery rate of BMP-2 in in vitro release experiments.
Article
Cell Biology
Wei Peng, Xingcheng Zhou, Tingting Xu, Yanwen Mao, Xiaohuan Zhang, Huiming Liu, Luqun Liang, Lingling Liu, Lirong Liu, Ying Xiao, Fan Zhang, Shuang Li, Mingjun Shi, Yuxia Zhou, Lei Tang, Yuanyuan Wang, Bing Guo
Summary: This study demonstrates that BMP-7 can upregulate the SnoN gene transcription through activating the Smad1/5 pathway, repairing the EMT and ECM deposition in renal tubular epithelial cells caused by diabetic kidney disease.
CELL DEATH & DISEASE
(2022)
Article
Polymer Science
Oana Gherasim, Alexandru Mihai Grumezescu, Valentina Grumezescu, Ecaterina Andronescu, Irina Negut, Alexandra Catalina Birca, Bianca Galateanu, Ariana Hudita
Summary: Osteoconductive and osteoinductive coatings are effective strategies for enhancing the integration of metallic implants with bone. Composite materials based on PLA and HAp benefit bone cell development, while the addition of osteogenic proteins contributes to new bone formation. Laser-processed composites show superior ability to promote osteoprogenitor cell adhesion, viability, and proliferation.
Article
Biochemistry & Molecular Biology
Yongwei Du, Gongwen Liu, Zhen Liu, Jianwen Mo, Miao Zheng, Qi Wei, Youjia Xu
Summary: Avermectin, a widely used insecticide, has been found to have significant toxic effects on bone development in zebrafish embryos. It disrupts early bone development, causes abnormal craniofacial chondrogenesis, and reduces bone mineralization. Avermectin also decreases the expression of genes related to osteogenesis and TGF-beta and BMP signaling pathways. The study provides insight into the mechanism of avermectin-induced damage on bone development and demonstrates its toxicity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Developmental Biology
Sahar Esfandyari, Nicola J. Winston, Michelle A. Fierro, Humberto Scoccia, Carlos Stocco
Summary: The study investigated the regulation of SFRP4 in cumulus cells and found that GDF9 and BMP15 can act together to stimulate SFRP4 expression.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Gitte L. Christensen, Maria L. B. Jacobsen, Anna Wendt, Ines G. Mollet, Josefine Friberg, Klaus S. Frederiksen, Michael Meyer, Christine Bruun, Lena Eliasson, Nils Billestrup
Article
Biochemistry & Molecular Biology
Jolanta Skarbaliene, Thomas Secher, Jacob Jelsing, Ansarullah, Trine S. R. Neerup, Nils Billestrup, Keld Fosgerau
Article
Endocrinology & Metabolism
Edward A. Phelps, Chiara Cianciaruso, Iacovos P. Michael, Miriella Pasquier, Jamil Kanaani, Rita Nano, Vanessa Lavallard, Nils Billestrup, Jeffrey A. Hubbell, Steinunn Baekkeskov
Article
Cell Biology
Michala Prause, Lukas Adrian Berchtold, Adriana Ibarra Urizar, Mette Hyldgaard Trauelsen, Nils Billestrup, Thomas Mandrup-Poulsen, Joachim Sterling
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Storling, Thomas Mandrup-Poulsen
JOURNAL OF DIABETES RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Jolanta Skarbaliene, Kristoffer T. Rigbolt, Keld Fosgerau, Nils Billestrup
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Biochemical Research Methods
Taewook Kang, Pia Jensen, Honggang Huang, Gitte Lund Christensen, Nils Billestrup, Martin R. Larsen
MOLECULAR & CELLULAR PROTEOMICS
(2018)
Article
Cell Biology
Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Hoist, Nils Billestrup, Joachim Storling
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2017)
Article
Toxicology
Anders Lundby, Pernille Bolvig, Anne Charlotte Hegelund, Bo F. Hansen, Jesper Worm, Anne Lutzen, Nils Billestrup, Christine Bonnesen, Martin B. Oleksiewicz
JOURNAL OF APPLIED TOXICOLOGY
(2015)
Article
Multidisciplinary Sciences
Jamil Kanaani, Chiara Cianciaruso, Edward A. Phelps, Miriella Pasquier, Estelle Brioudes, Nils Billestrup, Steinunn Baekkeskov
Article
Biochemistry & Molecular Biology
Michala Prause, Signe Schultz Pedersen, Violeta Tsonkova, Min Qiao, Nils Billestrup
Summary: Butyrate has been shown to prevent cytokine-induced dysfunction in pancreatic beta cells, potentially reducing the impact of inflammation in the progression of T2D. However, it may also affect cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Signe Schultz Pedersen, Michala Prause, Kristine Williams, Romain Barres, Nils Billestrup
Summary: This study found that butyrate inhibits IL-1 beta-induced inflammatory gene expression and NO production through suppression of NF-kappa B activation, potentially preserving beta cell function.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Signe Schultz Pedersen, Michala Prause, Christina Sorensen, Joachim Storling, Thomas Moritz, Eliana Marino, Nils Billestrup
Summary: This study investigated the effects of a high-amylose maize starch (HAMSB)-supplemented diet on glucose metabolism and inflammation in diabetic db/db mice. The results showed that the HAMSB diet significantly reduced blood glucose levels and increased insulin sensitivity in the mice. In addition, the HAMSB diet also reduced inflammation in the liver and adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barres, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup
Summary: Insufficient insulin secretion in type 2 diabetes is caused by decreased expression of key beta cell genes. BMP-2, an inflammatory factor, inhibits beta cell function and proliferation. This study investigated how BMP-2 induces beta cell dysfunction and loss of cell maturity.
CELL DEATH & DISEASE
(2023)