Editorial Material
Oncology
Yuqing Zhang, Rolf A. Brekken
Summary: The study challenges the functional significance of Tie2-expressing macrophages in tumor angiogenesis and relapse after chemotherapy, highlighting the need for reconsideration of Tie2 as a therapeutic target or prognostic indicator.
Article
Pharmacology & Pharmacy
Guangjiang Shi, Zixuan Zhang, Shuqian Ma, Yan Li, Shijia Du, Ya Chu, Yuan Li, Xinying Tang, Yong Yang, Zhen Chen, Zhuo Wang, Hongxi Wu
Summary: The study revealed the critical role of IRF8 in modulating hepatic microenvironment and its potential as a target for early treatment of I/R injury. Knockout of IRF8 reduced inflammatory cell infiltration, cytokine release, and liver enzyme levels after I/R, while overexpression aggravated liver damage. Additionally, IRF8-mediated inflammatory cell infiltration was partly dependent on autophagy and NF-kappa B signal pathway during I/R.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Jin Lei, Ming-Hui Zhou, Fu-Chi Zhang, Kang Wu, Sheng-Wen Liu, Hong-Quan Niu
Summary: Members of the IRF gene family, including IRF1, IRF2, IRF5, IRF8, and IRF9, are significantly upregulated in glioma and associated with advanced tumor grades and poorer outcomes. Low mutation rates but genetic alterations in IRFs are linked to more favorable patient survival. Functional analysis reveals IRFs involvement in glioma pathology mainly through inflammation- and immunity-related pathways, with correlations identified between IRFs and immune cell infiltration in glioma tissues. These findings suggest that IRF family members may serve as prognostic biomarkers and indicators of immune status in glioma patients.
Article
Cell Biology
Justa Friebus-Kardash, Fei Kuang, Tobias Peitz, Thamer A. Hamdan, Ute Eisenberger, Kristina Boss, Andreas Kribben, Karl Sebastian Lang, Michael Jahn
Summary: Patients on dialysis have dysfunctions of immune system responses. The expression of IRF8 is associated with the risk of infections in dialysis patients. Dialysis patients show reduced numbers of pDCs and increased numbers of natural killer cells and monocytes. IRF8 expression in pDCs, mDCs, and monocytes is lower in dialysis patients compared to healthy controls. Reduced IRF8 expression in pDCs is a potential risk factor predisposing dialysis patients to serious infections.
Article
Immunology
Peipei Zhang, Anja Schlecht, Julian Wolf, Stefaniya Boneva, Yannik Laich, Jana Koch, Franziska Ludwig, Myriam Boeck, Adrian Thien, Carmen Haerdtner, Katrin Kierdorf, Hansjuergen Agostini, Gunther Schlunck, Marco Prinz, Ingo Hilgendorf, Peter Wieghofer, Clemens Lange
Summary: This study showed that the loss of Irf8 in microglia has negligible effects on retinal homeostasis in the steady state, but is crucial for the suppression of retinal inflammation and choroidal neovascularization formation under pathological conditions.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Eleonora Makela, Karolina Pavic, Taru Varila, Urpu Salmenniemi, Eliisa Loyttyniemi, Srikar G. Nagelli, Tea Ammunet, Veli-Matti Kahari, Richard E. Clark, Laura L. Elo, Venkata Kumari Bachanaboyina, Claire M. Lucas, Maija Itala-Remes, Jukka Westermarck
Summary: A novel variant of the oncoprotein CIP2A, named NOCIVA, was discovered and found to be clinically relevant in predicting tyrosine kinase inhibitor therapy resistance in myeloid leukemias.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Ya-Ting Wang, Amy Sansone, Asya Smirnov, Christina L. Stallings, Anthony Orvedahl
Summary: Macroautophagy/autophagy regulates inflammation and protects against fatal disease caused by cytokine storm syndromes (CSS) in mice. Different mechanisms contribute to the hypersensitivity of autophagy gene-deficient mice in CSS models, and specific cell subsets play a protective role against different inflammatory stimuli.
Article
Medicine, Research & Experimental
Yan-Jie Chen, Shu-Neng Luo, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Ning-Ping Zhang, Li Liang
Summary: This study investigated the role of the IRF family in colorectal cancer (CRC) using bioinformatics approaches. Results showed that IRF family members can help predict both response to immunotherapy and clinical prognosis of patients with CRC. The study provides insights for further experimental exploration on IRF family members in CRC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marisa K. Kilgour, Sarah MacPherson, Lauren G. Zacharias, Abigail E. Ellis, Ryan D. Sheldon, Elaine Y. Liu, Sarah Keyes, Brenna Pauly, Gillian Carleton, Bertrand Allard, Julian Smazynski, Kelsey S. Williams, Peter H. Watson, John Stagg, Brad H. Nelson, Ralph J. DeBerardinis, Russell G. Jones, Phineas T. Hamilton, Julian J. Lum
Summary: Immune regulatory metabolites in the tumor microenvironment, such as 1-methylnicotinamide (MNA), play a key role in modulating T cell responses. Despite the elevated levels of MNA in T cells infiltrating tumors, the enzyme catalyzing MNA transfer is restricted to fibroblasts and tumor cells. Functionally, MNA induces T cells to secrete tumor-promoting cytokines, suggesting it as a potential immunotherapy target for human cancer treatment.
Article
Immunology
Quan Yang, Hongyan Xie, Xing Li, Yuanfa Feng, Shihao Xie, Jiale Qu, Anqi Xie, Yiqiang Zhu, Lu Zhou, Jinxue Yang, Xiaohao Hu, Haixia Wei, Huaina Qiu, Wenjuan Qin, Jun Huang
Summary: This study shows that IRF4 plays a crucial role in the development of PMN-MDSCs, and its deficiency can lead to an increase in PMN-MDSCs and enhanced suppressive activity, promoting tumor growth and metastasis. There is a correlation between the expression levels of IRF4 and c-Myc in clinical cancer patients, which may have predictive value for tumor progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Giulia Corradi, Barbara Bassani, Giorgia Simonetti, Sabina Sangaletti, Jayakumar Vadakekolathu, Maria Chiara Fontana, Martina Pazzaglia, Alessandro Gulino, Claudio Tripodo, Gianluca Cristiano, Lorenza Bandini, Emanuela Ottaviani, Darina Ocadlikova, Milena Piccioli, Giovanni Martinelli, Mario Paolo Colombo, Sergio Rutella, Michele Cavo, Marilena Ciciarello, Antonio Curti
Summary: The release of IFN gamma by AML cells induces a regulatory program in MSCs, leading to the induction of Treg in the bone marrow immune environment, contributing to an immuno-tolerant microenvironment of AML.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ibuki Harada, Haruka Sasaki, Koichi Murakami, Akira Nishiyama, Jun Nakabayashi, Motohide Ichino, Takuya Miyazaki, Ken Kumagai, Kenji Matsumoto, Maki Hagihara, Wataru Kawase, Takayoshi Tachibana, Masatsugu Tanaka, Tomoyuki Saito, Heiwa Kanamori, Hiroyuki Fujita, Shin Fujisawa, Hideaki Nakajima, Tomohiko Tamura
Summary: Chronic myeloid leukemia is driven by the oncogenic tyrosine kinase BCR-ABL, leading to compromised anti-tumor immunity due to restricted differentiation of conventional dendritic cells, increased expression of immunosuppressive PD-L1 in monocytes and basophils, and gene expression related to poor prognosis in basophils.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zhen Gan, Jun Cheng, Jing Hou, Liqun Xia, Yishan Lu, Pin Nie
Summary: The study identified a homologous IRF1 gene named Xt-IRF1 in amphibians, which has similar genomic structure and flanking genes, and shows inducible expression under various stimulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biology
Yunyun Zou, Nobuhiko Kamada, Seung-Yong Seong, Sang-Uk Seo
Summary: This study explores the phenotypic and functional heterogeneity of myeloid-derived suppressor cells (MDSCs) in tumor-bearing hosts. It identifies CD115(-) monocytic MDSCs as a distinct subtype with the potential to differentiate into OLFM4(hi) polymorphonuclear MDSCs. CD115(-) monocytic MDSCs increase in the blood and bone marrow as tumors progress, while preferentially differentiating into tumor-associated macrophages in the tumor mass.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
David Bradley, Alan J. Smith, Alecia Blaszczak, Dharti Shantaram, Stephen M. Bergin, Anahita Jalilvand, Valerie Wright, Kathleen L. Wyne, Revati S. Dewal, Lisa A. Baer, Katherine R. Wright, Kristin Stanford, Bradley Needleman, Stacy Brethauer, Sabrena Noria, David Renton, Joshua J. Joseph, Amy Lovett-Racke, Joey Liu, Willa A. Hsueh
Summary: This study found that the number of regulatory T cells in adipose tissue is reduced in obese individuals, which is associated with reduced insulin sensitivity and altered adipocyte metabolic gene expression. The number of regulatory T cells also decreases in lean individuals following induction of a high-fat diet. Interferon gamma plays a role in reducing the number and function of regulatory T cells in the adipose tissue of obese individuals, leading to adipose inflammation and insulin resistance.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Colleen S. Netherby, Michelle N. Messmer, Lauren Burkard-Mandel, Sean Colligan, Austin Miller, Eduardo Cortes Gomez, Jianmin Wang, Michael J. Nemeth, Scott I. Abrams
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder
NATURE COMMUNICATIONS
(2017)
Review
Biochemistry & Molecular Biology
Michelle N. Messmer, Annelise G. Snyder, Andrew Oberst
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Microbiology
Taryn E. Mockus, Shwetank, Matthew D. Lauver, Heather M. Ren, Colleen S. Netherby, Tarik Salameh, Yuka Imamura Kawasawa, Feng Yue, James R. Broach, Aron E. Lukacher
Article
Immunology
Shwetank, Elizabeth L. Frost, Taryn E. Mockus, Heather M. Ren, Mesut Toprak, Matthew D. Lauver, Colleen S. Netherby-Winslow, Ge Jin, Jennifer M. Cosby, Brian D. Evavold, Aron E. Lukacher
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Annelise G. Snyder, Nicholas W. Hubbard, Michelle N. Messmer, Sigal B. Kofman, Cassidy E. Hagan, Susana L. Orozco, Kristy Chiang, Brian P. Daniels, David Baker, Andrew Oberst
SCIENCE IMMUNOLOGY
(2019)
Article
Cell Biology
Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W. G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst
Article
Virology
Taryn E. Mockus, Colleen S. Netherby-Winslow, Hannah M. Atkins, Matthew D. Lauver, Ge Jin, Heather M. Ren, Aron E. Lukacher
JOURNAL OF VIROLOGY
(2020)
Article
Immunology
Heather M. Ren, Elizabeth M. Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S. M. Rahman, Brian D. Evavold, Aron E. Lukacher
SCIENCE IMMUNOLOGY
(2020)
Review
Immunology
Colleen S. Netherby-Winslow, Katelyn N. Ayers, Aron E. Lukacher
Summary: Tissue-resident memory (T-RM) CD8 T cells are a type of immune cells that provide early defense against regional pathogens and are predominantly located in nonlymphoid tissues. These cells show distinct transcriptional and phenotypic differences from central-memory T cells and effector-memory T cells, and these differences vary across barrier tissues and non-barrier organs. The factors contributing to the development and maintenance of brain T-RM involve T cell receptor (TCR) signal strength, duration, and modulation by inhibitory markers to balance activation and neuronal preservation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Amber S. Kleckner, Jennifer E. Reschke, Ian R. Kleckner, Allison Magnuson, Andrea M. Amitrano, Eva Culakova, Michelle Shayne, Colleen S. Netherby-Winslow, Susan Czap, Michelle C. Janelsins, Karen M. Mustian, Luke J. Peppone
Summary: This study investigated the impact of a Mediterranean Diet on cancer-related fatigue in patients undergoing chemotherapy. The study found that the Mediterranean Diet program significantly reduced fatigue at weeks 4 and 8. The program had a greater effect on patients with lower Mediterranean Diet scores at baseline. Additionally, fatigue was associated with mitochondrial dysfunction.
Meeting Abstract
Oncology
Jack C. Yalowich, Ragu Kanagasabai, Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams
Meeting Abstract
Immunology
Michelle N. Messmer, Annelise G. Snyder, Michael Y. Gerner, Andrew Oberst
JOURNAL OF IMMUNOLOGY
(2019)
Review
Oncology
Colleen S. Netherby, Scott I. Abrams
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)