Design, synthesis and evaluation of 4-phenyl-1,2,3-triazole substituted pyrimidine derivatives as antiproliferative and tubulin polymerization inhibitors

Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity

(2022) Zhipeng Huo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

(2022) Paola Oliva et al.   Pharmaceutics

Microtubules destabilizing agents binding sites in tubulin

(2022) Daniel Alpízar-Pedraza et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents

(2021) Hao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The tubulin code and its role in controlling microtubule properties and functions

(2020) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-targeting agents and their impact on cancer treatment

(2020) Vladimír Čermák et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Synthesis and anticancer activity of some pyrimidine derivatives with aryl urea moieties as apoptosis-inducing agents

(2020) Zühal Kilic-Kurt et al.   BIOORGANIC CHEMISTRY

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

(2019) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological evaluation of morpholines linked coumarin‐triazole hybrids as anticancer agents

(2019) Nerella Sridhar Goud et al.   Chemical Biology & Drug Design

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities

(2019) Fang Yang et al.   BIOORGANIC CHEMISTRY

Synthesis of Combretastatin‐A4 Carboxamidest that Mimic Sulfonyl Piperazines by a Molecular Hybridization Approach: in vitro Cytotoxicity Evaluation and Inhibition of Tubulin Polymerization

(2019) Chetna Jadala et al.   ChemMedChem

Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

(2018) Hany A.M. El-Sherief et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies

(2018) Bhupinder Kumar et al.   BIOORGANIC CHEMISTRY

Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity

(2018) Guoshun Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy

(2018) Souvik Banerjee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microtubule dynamics: an interplay of biochemistry and mechanics

(2018) Gary J. Brouhard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

(2018) Oskía Bueno et al.   Scientific Reports

KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR

(2018) Kaori Nakatani et al.   MOLECULAR CANCER THERAPEUTICS

Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents

(2017) Minjian Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies

(2016) David E. Clark et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microtubule destabilising agents: far more than just antimitotic anticancer drugs

(2016) Darcy Bates et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

(2016) P. Ballard et al.   CLINICAL CANCER RESEARCH

Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification

(2015) Veda Prachayasittikul et al.   SpringerPlus

Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy

(2014) Eva Brauchle et al.   Scientific Reports

Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors

(2011) Fuchun Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents

(2010) Nam Doo Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY