The physicochemical variables and interaction forces for the association of dodecyltrimethylammonium bromide plus cefixime trihydrate mixture in aq. short chain alcohols and urea media at different temperatures

To develop the drug formulation and reduce antibiotic resistance in the human body, it is essential to study the drug-surfactant interaction. Herein, the interactions between cefixime trihydrate (CMT) and dodecyltrimethylammonium bromide (DTAB) have been evaluated in different experimental situations at a certain range of temperature (300.55-320.55 K) by means of conductivity measurement. The micellar parameters (CMC, degree of counter ion binding (b THORN ) along with some thermodynamic variables like & UDelta;G0m, & UDelta;H0m, and & UDelta;S0m etc. were evaluated to investigate the interactions between CMT and DTAB. The plot of specific conductivity against surfactant concentration of the DTAB + CMT mixed system was used to determine critical micelle concentration (CMC). The increase of concentration of alcohols (ethanol and 1-propanol) and urea lowers the counterion binding and enhance the CMC values of the DTAB + CMT sys-tem. The increase in temperature causes delayed micellization of DTAB + CMT mixture both in aq. alco-holic and urea media. The alteration of CMC values of the DTAB + CMT implies the existence of interaction between DTAB and CMT in the study environment. The micellization of the DTAB + CMT mixed system in all experimental conditions investigated is spontaneous process that has been confirmed by the achieved negative values of & UDelta;G0m. The values of & UDelta;H0m and & UDelta;S0m expose the presence of hydrophobic and electrostatic interactions between CMT and DTAB while the contribution of electrostatic interaction is the main force in aq. EtOH medium.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Studying the interaction between drugs and surfactants is crucial for developing drug formulations and reducing antibiotic resistance. In this study, the interaction between cefixime trihydrate and dodecyltrimethylammonium bromide was evaluated under different experimental conditions, and various thermodynamic and micellar parameters were determined. The results showed that an increase in the concentration of alcohols and urea reduced the binding of counter ions and increased the critical micelle concentration of the mixed system. Higher temperatures delayed the micellization process. The findings indicate the existence of interactions between the two compounds, with electrostatic interactions being the main driving force in aqueous ethanol medium.