Journal
JOURNAL OF MEDICAL PRIMATOLOGY
Volume 51, Issue 5, Pages 288-291Publisher
WILEY
DOI: 10.1111/jmp.12616
Keywords
HIV-1 viral evolution; modeling SIV evolution using humanized mice; SIV cross-species transmission; SIVcpz evolution into HIV-1; viral evolution in humanized mice
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Funding
- National Center for Advancing Translational Sciences [UL1 TR002535]
- National Center for Research Resources
- National Institutes of Health [R01 AI123234, T32AI150547, OD011104, P51OD011106]
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Using humanized mice, researchers observed the evolution of SIV chimpanzee into HIV-1 Group M, with higher viral load, increased CD4(+) T-cell decline, and nonsynonymous substitutions indicating viral evolution.
Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV-1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV-1 Group M over the course of four generations. Higher initial viral load, increased CD4(+) T-cell decline, and nonsynonymous substitutions arose suggesting viral evolution.
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