Article
Engineering, Environmental
Xiaolei Yue, Chen Dong, Yucheng Wang, Zhishuai Cui, Zhihui Ren, Zheng-Hui Guan
Summary: In this study, a novel multi-stimuli responsive intelligent actuating polyurethane material, AzoPU50, was prepared through co-polymerization. The material can respond to three types of stimuli - heat, light, and humidity - to trigger shape deformation movements. This work provides a new strategy for developing multi-stimuli-responsive smart actuating devices and intelligent materials/systems.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Derong Lu, Shuai Hou, Sheng Liu, Qirong Xiong, Yonghao Chen, Hongwei Duan
Summary: We report the self-assembly of polymer-coated magnetoplasmonic Janus nanoparticles driven by amphiphilicity, which results in well-defined colloidal ensembles with controllable size, morphology, and dimension. By coating pH-responsive block copolymer and hydrophilic polymers on plasmonic and magnetic sides of the nanoparticles, respectively, we can achieve a direct correlation between the amphiphilicity of the building blocks and the structural parameters of the ensembles. This study provides insight into the self-assembly of functional nanocrystals and offers possibilities for tuning interparticle distance and studying metal-fluorophore interaction.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Yuman Dong, Peng Liu
Summary: This study synthesized an amphiphilic triblock copolymer prodrug with pH/reduction dual-triggered drug delivery for tumor treatment, which showed reduced premature drug leakage and selective cytotoxicity to cancer cells.
Article
Chemistry, Inorganic & Nuclear
William D. J. Tremlett, Tilo Soehnel, James D. Crowley, L. James Wright, Christian G. Hartinger
Summary: Using ferrocene-based ligand systems, a series of heterobimetallic architectures were designed to release and bind guest molecules. The complexes were characterized using various techniques and the disassembly and reassembly process of metallosupramolecular structures were investigated using NMR spectroscopy. Guest binding studies revealed interactions with anionic guests and the release of guests was induced by Cl- ions.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Karan Bansal, Dean Webster, Mohiuddin Quadir
Summary: We studied the self-assembly and colloidal properties of poly(ethylene glycol) conjugated sucrose soyate polyols. The synthesized PSSP products showed amphiphilicity and reduced water surface tension. The nanoparticles formed by PSSP self-assembly in water can encapsulate hydrophobic compounds.
Article
Nanoscience & Nanotechnology
Jackson Benda, Hayato Narikiyo, Shane J. Stafslien, Lyndsi J. VanderWal, John A. Finlay, Nick Aldred, Anthony S. Clare, Dean C. Webster
Summary: This study focuses on fine-tuning the amphiphilic properties of a siloxane-polyurethane (SiPU) coating by adjusting the content of PDMS and PEG in the coating matrix. The addition of surface-modifying amphiphilic additives further enhances the antifouling/fouling-release properties of the coatings. The results show that formulations with higher amounts of these additives exhibit significantly improved fouling-release performance, surpassing that of commercial standard FR coatings.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti
Summary: A straightforward two-step procedure was developed to convert commercial materials into anticancer ionic complexes via CO removal, which showed promising antiproliferative activity against human cancer cell lines. These complexes also displayed significant cytotoxic activity against human cancer 3D cell cultures.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Ke Zheng, Xinxin Liu, Hongyan Liu, Dianquan Dong, Linlin Li, Libin Jiang, Mingdong Huang, Caifeng Ding
Summary: In this study, β-cyclodextrins were modified by acetonization to improve drug loading capacity for the chemotherapy drug doxorubicin. The modified cyclodextrins self-assembled into nanoparticles with a photosensitizer for antitumor therapy, showing excellent stability and pH-sensitive drug release characteristics. In vivo experiments demonstrated significant tumor targeting and antitumor activity with minimal side effects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Han Hu, Qingyang Luan, Jiayi Li, Chen Lin, Xingyu Ouyang, Dong-Qing Wei, Jinggang Wang, Jin Zhu
Summary: This study overcame the poor thermal stability of disulfide bonds in melt polycondensation and successfully synthesized polyesters with good mechanical and barrier properties. The study also found that the oxidation products of disulfide bonds have stronger polarity and hydrophilicity, accelerating the hydrolysis of polyesters.
Article
Chemistry, Inorganic & Nuclear
Jian-Jun Liu, Jia-Jia Fu, Teng Liu, Xianfu Shen, Fei-Xiang Cheng
Summary: Host-guest systems based on donor-acceptor interactions are a new platform for preparing luminescent metal-organic frameworks. Designing and modulating charge transfer-based fluorescence in these systems is challenging. In this study, the researchers successfully fabricated a series of host-guest materials that exhibit charge transfer-based fluorescence by using electron-rich naphthalene derivatives and an electron-deficient naphthalene diimide-based MOF as the donor and acceptor, respectively. By selecting different naphthalene derivatives, the emitted color can be tuned. Electronic structure calculations showed that the multicolor emissions of these MOFs depend on the energy levels of the naphthalene derivatives.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Polymer Science
Ruizhen Zhang, Yuting Min, Peipei Ji, Guiyang Zhou, Hong Yin, Dongming Qi, Hangjun Deng, Zan Hua, Tao Chen
Summary: With the increasing demand for treating cancer and cardiovascular diseases, researchers have intensively studied drug delivery therapy using intelligent nanocarriers. In this study, light and temperature dual-responsive micelles were designed and fabricated, and their controlled release property was investigated using a hydrophobic fluorescent dye. Through the manipulation of light and temperature, different degrees of release capabilities were achieved, providing an approach for the construction of controllable drug release carriers.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kui Wang, Xiao-Yan Wang, Guo-Jie Gao, Mi-Ni Wang, Ying-Ying Yu, Siyang Xing, Bolin Zhu
Summary: A pH-triggered transition from micellar aggregation to a host-guest complex was achieved by supramolecular interactions between calixpyridinium and pyrroloquinoline quinone disodium salt (PQQ-2Na), accompanied by a color change. This transition was further studied as a controllable-release model due to the low toxicity of the involved compounds.
Article
Polymer Science
Xin Zhang, Mengmeng Zhang, Mingyue Wu, Linchuan Yang, Rui Liu, Rui Zhang, Tongtong Zhao, Ci Song, Gang Liu, Qingzeng Zhu
Summary: The study successfully developed a light-triggered charge reversal nanoparticle release system for precise control of targeted molecule release, incorporating photocleavage-bridged polysilsesquioxane nanoparticles as carriers for doxorubicin. The nanoparticles could reverse their surface charge from negative to positive upon light irradiation, enabling controlled release of loaded molecules. By regulating irradiation parameters, the release of doxorubicin was precisely controlled, showcasing the system's potential applications in biomedical technology.
Article
Multidisciplinary Sciences
Xin Li, Laura Hetjens, Nadja Wolter, Helin Li, Xiangyang Shi, Andrij Pich
Summary: In this study, lysozyme-responsive microgels were developed for the treatment of inflammatory bowel disease. Compared to other pH-responsive carriers, lysozyme-responsive microgels can better identify healthy and inflamed intestines, achieving effective treatment with fewer side effects.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Polymer Science
Subrata Santra, Soumya Kolay, Sujauddin Sk, Debleena Ghosh, Anmol Mishra, Lisa Roy, Kishor Sarkar, Mijanur Rahaman Molla
Summary: The synthesis of a self-immolative polymer from recycled plastic waste has led to the development of a stable micellar nanostructure that efficiently encapsulates hydrophobic guest molecules. The nanoassembly demonstrates properties of a nanocontainer through hydrophobic interactions as well as supramolecular cross-linking in the core. The controlled release of guest molecules in a redox environment and the regulated charge modulation of the nanoassembly make it a promising candidate for targeted drug delivery.
Article
Chemistry, Organic
Sk Asraf Ali, Anirban Bera, Susanta Kumar Manna, Subrata Santra, Mijanur Rahaman Molla, Shubhankar Samanta
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Subrata Santra, Mursed A. Sk, Arun Mondal, Mijanur R. Molla
Article
Polymer Science
Sk. Mursed Ali, Subrata Santra, Arun Mondal, Soumya Kolay, Lisa Roy, Mijanur Rahaman Molla
Summary: The role of nonpolar co-solvents in initiating supramolecular polymerization and forming 1D nanowires has been studied by synthesizing a fluorophore-spacer-receptor derivative. The efficient gel formation in non-polar solvents is supported by microscopic and rheological data. Analysis of co-solvent composition reveals the crucial role of a critical co-solvent composition in initiating the polymerization process.
Article
Materials Science, Multidisciplinary
Subrata Santra, Arpan Ghosh, Arun Mondal, Sk. Mursed Ali, Dishan Das, Kishor Sarkar, Lisa Roy, Mijanur Rahaman Molla
Summary: This study focused on the controlled synthesis of polyurethanes with recycled plastic waste to investigate the impact of polymer molar mass on the thermodynamics of self-assembly. The stable micellar nanostructure with environment-specific surface charge modulation and controlled guest release can significantly contribute to the development of robust chemotherapeutics.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Biomaterials
Subrata Santra, Shreya Das, Arunima Sengupta, Mijanur Rahaman Molla
Summary: A covalently cross-linked nanoassembly, called nanonetwork (NN), was designed and synthesized, which showed dual pH responsiveness for stable sequestration and sustained release of drug molecules in response to endosomal pH. The nanonetwork, fabricated from an amphiphile integrated with tertiary amine and acrylate functionalities, exhibited entropically driven self-assembly and micellar nanostructures. The cross-linking of the micellar core with thiol-acrylate Michael addition click reaction generated acid labile β-thioester functionalities, enabling slow hydrolysis and sustained release of the anti-cancer drug doxorubicin at endosomal pH.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Sk Mursed Ali, Sujauddin Sk, Ankita Sengupta, Subrata Santra, Souvik Barman, Nayim Sepay, Mijanur Rahaman Molla
Summary: This paper presents the successful synthesis of luminescent and highly conducting supramolecular polymers with the assistance of fluoride anions in a moderately polar organic solvent. The polymerization process is guided by multiple factors, resulting in complex nanoscale structures. Furthermore, the quantity and nature of the anions significantly affect the morphology and properties of the polymers.
Article
Polymer Science
Subrata Santra, Soumya Kolay, Sujauddin Sk, Debleena Ghosh, Anmol Mishra, Lisa Roy, Kishor Sarkar, Mijanur Rahaman Molla
Summary: The synthesis of a self-immolative polymer from recycled plastic waste has led to the development of a stable micellar nanostructure that efficiently encapsulates hydrophobic guest molecules. The nanoassembly demonstrates properties of a nanocontainer through hydrophobic interactions as well as supramolecular cross-linking in the core. The controlled release of guest molecules in a redox environment and the regulated charge modulation of the nanoassembly make it a promising candidate for targeted drug delivery.
Article
Chemistry, Multidisciplinary
Sanchaita Mondal, Moumita Saha, Mousumi Ghosh, Subrata Santra, Mijan A. Khan, Krishna Das Saha, Mijanur R. Molla
NANOSCALE ADVANCES
(2019)
