Article
Pharmacology & Pharmacy
Bo Zhang, Meng-Lu Wang, Shu-Ming Huang, Yu Cui, Yan Li
Summary: This study investigated the mechanism by which Kaixin-San (KXS) mitigates the toxic effects of amyloid-beta protein (Aβ) by regulating the expression of postsynaptic AMPA receptors (AMPARs). The results showed that KXS effectively improved the learning and memory impairment caused by Aβ, and reversed the inhibition of hippocampal long-term potentiation (LTP) induced by Aβ. The expression levels of several accessory proteins associated with AMPAR expression were also altered by KXS. These findings provide novel insights into the mechanism underlying the neuroprotective effects of KXS against Aβ-induced memory impairment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Alan D. Snow, Joel A. Cummings, Rudolph E. Tanzi, Thomas Lake
Summary: Memory loss is primarily caused by the accumulation of brain plaques, tangles, and inflammation. This study compared the ability of major memory-support dietary supplements to reduce Aβ 1-42 fibrils and tau protein paired helical/straight filaments. Percepta was found to be the most effective supplement in reducing both Aβ 1-42 fibrils and tau paired helical/straight filaments compared to other supplements tested.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sarah Bonk, Kevin Kirchner, Sabine Ameling, Linda Garvert, Henry Volzke, Matthias Nauck, Uwe Voelker, Hans J. Grabe, Sandra Van der Auwera
Summary: This study aimed to replicate the interaction between APOE epsilon 4 status and depression on memory function and explore the role of circulating plasma miRNAs. The results confirmed the effect of depressive symptoms and APOE epsilon 4 status on memory performance and identified hsa-miR-107 as a possible biological link between APOE epsilon 4, depressive symptoms, and cognitive impairment.
Article
Food Science & Technology
Yu-Shi Gong, Fang-Li Hou, Juan Guo, Lin Lin, Fu-Yong Zhu
Summary: The study found that high-dose alcohol intake impairs learning and memory abilities, increases A beta content and deposition, and promotes the progression of AD; while low-dose alcohol can mitigate excessive production of A beta and counteract the development of AD.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Kevin A. Murray, Carolyn J. Hu, Sarah L. Griner, Hope Pan, Jeannette T. Bowler, Romany Abskharon, Gregory M. Rosenberg, Xinyi Cheng, Paul M. Seidler, David S. Eisenberg
Summary: Neurodegenerative diseases are characterized by the accumulation of aggregated proteins, and inhibiting the formation of these aggregates is a potential therapeutic strategy. Using de novo protein design, researchers have developed a library of mini-protein inhibitors that specifically target the amyloid structures of tau, Aβ, and α Syn. These inhibitors show promising results in preventing aggregation and rescuing motor deficits in animal models of PD and AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Albin John, P. Hemachandra Reddy
Summary: Alzheimer's disease is a progressive disease associated with synaptic dysfunction, with researchers striving to find more information on disease progression and pathogenesis. Synaptic pathology and mitochondrial oxidative damage are early events in the progression of AD, with synaptic loss and damage being key correlates of cognitive deficits in patients. As the disease advances, significant changes occur at the synapse, shedding light on the disease progression and serving as potential markers and therapeutic targets.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Lei Liu, Hyunchang Kwak, Trebor L. Lawton, Shan-Xue Jin, Angela L. Meunier, Yifan Dang, Beth Ostaszewski, Alison C. Pietras, Andrew M. Stern, Dennis J. Selkoe
Summary: The study developed a new method for detecting and quantifying soluble oligomers of amyloid beta protein in human plasma. The method is highly sensitive, cost-effective, and suitable for high throughput analysis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Antoine Leuzy, Niklas Mattsson-Carlgren, Nicholas C. Cullen, Erik Stomrud, Sebastian Palmqvist, Renaud La Joie, Leonardo Iaccarino, Henrik Zetterberg, Gil Rabinovici, Kaj Blennow, Shorena Janelidze, Oskar Hansson
Summary: This study examined the comparability of cutoffs for Elecsys immunoassays for different measurements in cerebrospinal fluid (CSF) in predicting Alzheimer's disease (AD)-related outcomes. The results showed that CSF A beta 42/p-tau181 was more robust to measurement variability and may be the preferred measure in clinical practice and trials. The findings also indicated that the use of plasma A beta 42/40 led to a greater number of individuals falling within the gray zone.
ALZHEIMERS & DEMENTIA
(2023)
Review
Endocrinology & Metabolism
Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu
Summary: This article summarizes the regulatory effects of APP and its cleavage peptides on metabolism in the central nervous system and peripheral tissues, indicating that peptides generated by non-amyloidogenic processing can have positive effects on metabolism, while those produced by amyloidogenic processing may have negative impacts. Abnormal expression of APP is associated with metabolic diseases (such as diabetes, obesity, etc.) and cancer.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Biochemistry & Molecular Biology
Vladimir Rudajev, Jiri Novotny
Summary: This article discusses the relationship between cholesterol and the development of Alzheimer's disease, as well as the influence of cholesterol on the production of amyloid beta (Aβ).
CELL AND BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero, Clelia Dispenza, Daniela Giacomazza
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, characterized by senile plaques and neurofibrillary tangles. There is currently a lack of treatment options aside from symptomatic medications. This review presents research results on the use of peptides of different sizes for the treatment of Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyeon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han, Mu-Hyun Baik, Young-Ho Lee, Mi Hee Lim
Summary: This study reveals that the interaction between APP-C31 and Aβ40 peptides promotes the aggregation and toxicity of Aβ40, leading to nuclear damage, neurite degeneration, and inflammation. This finding may offer a novel target for developing treatments for AD.
Article
Biochemistry & Molecular Biology
Rhett J. Britton, James M. Hutchison, Charles R. Sanders
Summary: In Alzheimer's disease (AD) research, the proteins of interest are amyloid precursor protein (APP) and tau, which play crucial roles in the disease mechanism. The relationship between A beta and tau pathologies remains unclear, with studies suggesting that A beta may induce or enhance tau protein formation in neurofibrillary tangles.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Chen Ma, Fenfang Hong, Shulong Yang
Summary: This review provides an overview of the amyloid hypothesis of Alzheimer's disease, emphasizing the key role of amyloid beta protein in AD. The review also discusses the process of amyloid formation, autophagy, cerebral blood flow, and the detailed pathogenesis of amyloidosis.
Review
Cell Biology
Gozal Bahlakeh, Ali Gorji, Hamid Soltani, Tahereh Ghadiri
Summary: miRNAs play a significant role in cognitive function, with certain miRNAs levels affecting cognitive performance. Induction or reduction of specific miRNAs can improve or enhance cognitive function, while synaptic dysfunction is a core cause of cognitive dysfunction.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Li-na Sun, Xiao-long Li, Fei Wang, Jun Zhang, Dan-dan Wang, Li Yuan, Mei-na Wu, Zhao-jun Wang, Jin-shun Qi
JOURNAL OF NEUROSCIENCE RESEARCH
(2017)
Article
Neurosciences
Hanmeng Zhang, Lianwei Mu, Dandan Wang, Dongdong Xia, Alexander Salmon, Qiuli Liu, Margaret T. T. Wong-Riley
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Review
Oncology
Dandan Wang, Subramaniam Malarkannan
Article
Multidisciplinary Sciences
Mary Jo Rademacher, Anahi Cruz, Mary Faber, Robyn A. A. Oldham, Dandan Wang, Jeffrey A. Medin, Nathan J. Schloemer
Summary: Lentiviral transduction of sarcoma cells to express IL-12 can induce high-level expression of IL-12 and elicit specific immune responses in murine models, particularly mature human NK cells. IL-12 immunomodulation through autologous tumor transduction and reintroduction shows promise for sarcoma treatment and warrants further exploration.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kate J. Dixon, Jason R. Siebert, Dandan Wang, Alex M. Abel, Kaitlin E. Johnson, Matthew J. Riese, Scott S. Terhune, Vera L. Tarakanova, Monica S. Thakar, Subramaniam Malarkannan
Summary: The signaling adapter MyD88 is critical for immune cell activation in response to viral or bacterial pathogens, but its role in NK cell development seems to be dispensable. However, MyD88 significantly affects the cytotoxic function and inflammatory cytokine production of NK cells, particularly in the context of Ly49H-dependent gene signatures.
MOLECULAR IMMUNOLOGY
(2021)
Review
Cell Biology
Mohamed Khalil, Dandan Wang, Elaheh Hashemi, Scott S. Terhune, Subramaniam Malarkannan
Summary: The article discusses the differences between the innate and adaptive immune systems, including signaling pathways and cytokine-mediated effects. The functional relevance of the 'third' signal in NK cells remains elusive.
Article
Immunology
Elaheh Hashemi, Stacey Bjorgaard, Dandan Wang, Bradley Uyemura, Matthew Riese, Monica S. Thakar, Subramaniam Malarkannan
Summary: Fanconi anemia is a genetic disorder characterized by congenital malformations, pancytopenia, and predisposition to hematological malignancies and tumors. In addition to bone marrow failure and increased risk of leukemia, immune dysregulation is also observed in FA patients, particularly affecting the function of NK cells. Further research is needed to understand the molecular mechanisms underlying these defects and implications for future treatments.
CRITICAL REVIEWS IN IMMUNOLOGY
(2021)
Article
Immunology
Dandan Wang, Bradley Uyemura, Elaheh Hashemi, Stacey Bjorgaard, Matthew Riese, James Verbsky, Monica S. Thakar, Subramaniam Malarkannan
Summary: Natural killer (NK) cells play a major role in innate immunity and have high clinical value in cancer treatment. The master regulator GATA2 is crucial in driving the commitment of common lymphoid progenitors into immature NK progenitors, affecting the development of human NK cells.
CRITICAL REVIEWS IN IMMUNOLOGY
(2021)