RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells

TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

(2020) Jianwen Chen et al.   Nature Communications

RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis

(2020) Huazhi Zhang et al.   Autophagy

Eph Receptors and Ephrins: Therapeutic Opportunities

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Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

TNFα-activated stromal COX-2 signalling promotes proliferative and invasive potential of colon cancer epithelial cells

(2013) M. Zhu et al.   CELL PROLIFERATION

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

(2013) Mélissa Beaudoin et al.   PLoS Genetics

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression

(2009) Maria Genander et al.   CELL

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

TNF: A master switch for inflammation to cancer

(2008) Gautam Sethi   Frontiers in Bioscience-Landmark