Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 438, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2022.129459
Keywords
COPD; LncRNAMHC-R; GATA3; Dendriticcell; AirpollutionPM
Categories
Funding
- National Natural Science Foundation of China [81970045]
- Guangdong Natural Science Foundation, China [2019A1515011430, 2020A1515010264]
- Guangdong Medical Research Foundation, China [A2018272]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program, China [2017BT01S155]
- Zhongnanshan Medical Foundation of Guangdong Province, China [ZNSA-2020013]
- Science and Technology Program of Guangzhou, China [202002030080]
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Chronic obstructive pulmonary disease (COPD) is a heterogeneous illness characterized by aberrant inflammatory immune reaction in the lung due to noxious particles and gases. Recent research has found that long noncoding RNAs (lncRNAs), particularly lncRNA MHC-R, may play a crucial role in the pathogenesis of COPD by regulating the immune activities of dendritic cells (DCs).
Chronic obstructive pulmonary disease (COPD) is a heterogeneous illness associated with aberrant inflammatory immune reaction in the lung in response to noxious particles and gases. Our previous epidemiological studies discovered that long-term exposure to air pollution PM was associated with an increase in the incidence of COPD and lung function decline, but the impact of air pollution on the onset of COPD and its pathogenesis remains obscure. In recent years, long noncoding RNAs (lncRNAs) have been documented to have a crucial role in COPD. Our preliminary study found that the expression of lncRNA MHC-R in the lung tissues of rats exposed to air pollution PM was dramatically elevated, and the specific expression was mainly focused on the immune-related MHC I, antigen-presenting, and adaptive immune response. After transcription factor prediction, it was found that GATA3 could be combined with the specific sequence of the lncRNA MHC-R promoter region. Dendritic cells (DCs) are necessary antigen-presenting cells (APCs) with the most potent antigen-presenting function. We proved that GATA3/lncRNA MHC-R might regulate the immune activities of DCs to participate in the pathogenic mechanism of COPD induced by air pollution PM, which opens up a new way for early COPD diagnosis and treatment.
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