Journal
CARBOHYDRATE POLYMERS
Volume 123, Issue -, Pages 331-338Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.01.059
Keywords
Chondroitin sulfate; Polysaccharide; N-Deacetylation; Immune response
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Funding
- National Natural Science Foundation of China (NSFC) [31270860]
- Program for New Century Excellent Talents in University [NCET-13-0480]
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As a major component in extracellular matrix of the tissue, chondroitin sulfate A (CS-A) has been shown to exhibit either pro- or anti-inflammatory immune response which was largely dependent on its molecular size and cell types. In this study, we determined the signaling pathway involved in immune response of CS and its N-deacetylated derivative (dCS). Our data indicated that both CS and dCS could activate the NF-kappa B transcription factor in antigen presenting cells and induce TNF-alpha production through the TLR/MyD88 pathway. Further studies demonstrated that both CS and dCS had a potential in promoting the proliferation of spleen lymphocytes, and promoting the cytokines secretion by OVA-sensitized splenocytes. Thus, our finding provided a mechanistic insight into the understanding of cellular immunity of CS and dCS, which might be helpful to develop CS-based immune modulators against chronic inflammatory conditions, autoimmunity, infectious diseases, allergies and asthmatic conditions. (C) 2015 Elsevier Ltd. All rights reserved.
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