Article
Chemistry, Physical
Jinpeng Liu, Ranran Cheng, Kirsten Heimann, Zhongni Wang, Jinying Wang, Feng Liu
Summary: The study successfully developed temperature-sensitive lyotropic liquid crystals (LLC) that can adjust their structure to match human body temperature, showing potential for application as transdermal drug delivery systems by influencing their composition and temperature.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Guillermo Blanco-Fernandez, Barbara Blanco-Fernandez, Anxo Fernandez-Ferreiro, Francisco J. Otero-Espinar
Summary: Liquid crystals possess unique physicochemical properties that make them applicable in various fields. This article provides an overview of the current landscape of lipidic liquid crystals in biomedical applications, with a focus on drug delivery, tissue engineering, and molecular imaging. The limitations and future prospects of lipidic liquid crystals in these applications are also discussed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biophysics
Annija Stepulane, Kajsa Ahlgren, Adrian Rodriguez-Palomo, Anand Kumar Rajasekharan, Martin Andersson
Summary: In this study, silicone-based lyotropic liquid crystal elastomers with drug-eluting functionality were developed using PDMS and triblock copolymer (DA-F127). Various compositions were explored and evaluated, and three compositions with specific properties of interest were further investigated. The materials demonstrated the ability to encapsulate and release polar and nonpolar substances, with sustained release profiles for up to 6 and 5 days for vancomycin and ibuprofen, respectively. This research presents a lyotropic liquid crystal, silicone-based elastomer with tailorable mechanical properties, water retention capacity, and the ability to host and release active substances.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Vivek P. Chavda, Sathish Dyawanapelly, Shilpa Dawre, Ines Ferreira-Faria, Rajashri Bezbaruah, Niva Rani Gogoi, Praveen Kolimi, Divyang J. Dave, Ana Claudia Paiva-Santos, Lalitkumar K. Vora
Summary: Liquid crystal-based nanoformulations are efficient in delivering drugs and therapeutics to specific biological sites. Lyotropic liquid crystalline phases (LLCPs) have unique characteristics that make them promising drug delivery systems, offering improved drug loading, stability, and controlled release. Factors such as molecule shape, microsegregation, and chirality play important roles in the formation of these liquid crystalline phases. Additionally, due to their similarity to biological membranes, liquid crystals demonstrate higher bioadhesivity and biocompatibility, making them more effective for targeted drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Dong-Dong Xu, Ru-Ru Ma, Ai-Ping Fu, Zhao Guan, Ni Zhong, Hui Peng, Ping-Hua Xiang, Chun-Gang Duan
Summary: This study demonstrates the reversible polarization switching in a van der Waals ferroelectric by controlling the ferroelectric-liquid interface structure. By inducing upward and downward polarization states through physical adsorption of organic ions at the ferroelectric-liquid interface, this approach offers opportunities for liquid-controlled two-dimensional ferroelectric-based devices with super-long retention time.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Medicinal
Maria Chountoulesi, Stergios Pispas, Ioulia K. Tseti, Costas Demetzos
Summary: This review provides an overview of the engineering and characterization of non-lamellar lyotropic liquid crystalline nanosystems (LLCN), highlighting their advantages as drug delivery nanocarriers and innovative vaccine platforms. Non-lamellar LLCN demonstrate stimuli-responsive and controlled release properties, as well as unique adjuvant properties for immune system activation.
Article
Chemistry, Multidisciplinary
Vera Tchakalova, Cristiano Luis Pinto Oliveira, Antonio Martins Figueiredo Neto
Summary: A new lyotropic, fragranced, viscoelastic fluid with a complex structure is obtained from fragranced microemulsions by adding a fatty acid. The formation of anisotropically shaped and highly oriented micelles in aqueous solution is achieved by nonhomogeneous mixing of an appropriate nonionic surfactant, a fatty acid, and a fragrance oil. The viscosity and nano- and microstructures of the fluid are controlled by the balance of fatty acids and fragrance molecules, which behave as a cosurfactant and segregate in the micelles. X-ray scattering and rheological methods characterize the transition from isotropic microemulsion to a more structured viscoelastic solution. With the ability to solubilize and retain fragrance, this complex structured fluid can be used as a 2-in-1 fragrance-solubilizing liquid product compatible with various consumer products for home and body care.
Article
Biochemistry & Molecular Biology
Chloe Seyrig, Alexandre Poirier, Thomas Bizien, Niki Baccile
Summary: This study demonstrates the development of functional hydrogels with in situ responsivity of their elastic properties by external stimuli, using entirely sustainable materials. The elastic properties of the hydrogels can be modulated by selectively triggering the phase transition of the components.
Article
Chemistry, Applied
Shannon P. Callender, Shawn D. Wettig
Summary: Microemulsion systems have gained significant interest in pharmaceutical applications, with non-ionic surfactants being preferred for their uncharged nature and safety profile. The study analyzed the phase behavior and microemulsion formation of four non-ionic surfactants, revealing differences in behavior despite similar hydrophilic-lipophilic balance values. Surfactants like Polysorbate 80 and PEG-40 hydrogenated castor oil showed high synergism and potential for various applications.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2021)
Article
Pharmacology & Pharmacy
Maria Chountoulesi, Diego Romano Perinelli, Aleksander Forys, Varvara Chrysostomou, Archontia Kaminari, Giulia Bonacucina, Barbara Trzebicka, Stergios Pispas, Costas Demetzos
Summary: The study focuses on the challenging sub-cellular targeting and stimuli-responsiveness in pharmaceutical nanotechnology. Glyceryl monooleate (GMO)-based non-lamellar lyotropic liquid crystalline nanoparticles were stabilized by a polymeric block copolymer, which enabled sub-cellular targeting, stimuli-responsiveness, and stealthiness. The physicochemical characteristics, morphology, and drug release profile of the nanosystems were investigated through various techniques. The results showed that the properties of the nanosystems were dependent on the combination of polymeric stabilizers, and the nanosystems exhibited targeted drug delivery to lysosomes with a stimuli-triggered drug release profile.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Alireza Poustforoosh, Hassan Hashemipour, Abbas Pardakhty, Maryam Kalantari Pour
Summary: Meloxicam, a widely used drug, was prepared in nanostructural form using the microemulsion method in this study. The release rate and variation were investigated experimentally and predicted through simulation, and the release into the skin tissue was also predicted.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Biophysics
Guilherme Rodolfo Souza de Araujo, Givalda Mendonca da Cruz Macieira, Dayane Xavier de Oliveira, Saulo Santos Matos, Quesia Nery dos Santos, Larissa Otubo, Adriano Antunes de Souza Araujo, Marcelo Cavalcante Duarte, Ana Amelia Moreira Lira, Rogeria de Souza Nunes, Victor Hugo Vitorino Sarmento
Summary: The study demonstrated that microemulsions using PPG-5-CETETH-20 can enhance the skin permeation of nifedipine by increasing the diffusion and partition coefficients of the drug in the skin.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Vamseekrishna Ulaganathan, Anupam Sengupta
Summary: The study shows that the nanoporous PDMS surfaces of a rectangular microfluidic channel can selectively uptake water molecules, concentrating the solute molecules in an aqueous phase, and drive phase transitions. Factors such as surface wettability, channel geometry, surface-to-volume ratio, and surface topography play a crucial role in tuning the phase transitions in a spatial and temporal manner. These findings provide insights into material assembly and biological manipulation in microfluidic environments.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Crystallography
Anshul Sharma, Irvine Lian Hao Ong, Anupam Sengupta
Summary: The nematic and columnar phases of lyotropic chromonic liquid crystals (LCLCs) have been extensively studied for their importance in material science and medical diagnostics. This study focuses on the emergence of time dependent textures in confined LCLCs, using soft lithography, surface characterization, and polarized optical imaging to analyze the confinement-induced LCLC textures. Varying confinement geometry, anchoring conditions, and initial DSCG concentration allows for tuning the temporal dynamics of the N- to M-phase transition and textural behavior of the confined LCLC.
Article
Chemistry, Multidisciplinary
Beibei Lu, Yiyang Bo, Mingjie Yi, Zhenyuan Wang, Jichuan Zhang, Zhenye Zhu, Yanli Zhao, Jiaheng Zhang
Summary: The study successfully synthesized an L-(-)-carnitine-based ionic liquid and developed IL/O ME to improve drug solubility and protein permeability.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Vivek P. Chavda, Rajashri Bezbaruah, Sheetal Dolia, Nirav Shah, Sachin Verma, Shrinivas Savale, Suma Ray
Summary: COVID-19 pandemic has caused widespread transmission and millions of deaths globally. Despite research efforts and clinical trials, a specific and 100% effective treatment for severe cases has yet to be found. This article focuses on the potential of convalescent plasma therapy as a treatment option for COVID-19.
PROCESS BIOCHEMISTRY
(2023)
Review
Immunology
Vivek P. Chavda, Toshika Mishra, Suneetha Vuppu
Summary: The zoonotic SARS-CoV-2 virus undergoes evolution, adaptation, and selection to develop variants that result in the pandemic. The spike protein, required for binding to host cells, has a high propensity for mutations, generating numerous variants. Hybrid variants can also be produced through recombination of genomic sequences from two different lineages of the virus. Genome sequencing is the most accurate approach for identifying the hybrid variants, while immunological diagnostic assays provide insight into their pathogenesis and reactions.
Review
Immunology
Vivek P. Chavda, Pankti Balar, Dixa Vaghela, Hetvi K. Solanki, Akta Vaishnav, Vivek Hala, Lalitkumar Vora
Summary: Omicron variants have had a significant impact globally, with a high rate of transmissibility making their management difficult. There are multiple subtypes of omicron, including BA.1, BA.2, BA.3, BA.4, and BA.5. An additional omicron subvariant BF.7 has recently emerged in some parts of India. Further studies are needed to better understand the new variant and its implications.
Review
Biochemistry & Molecular Biology
Vivek P. Chavda, Amit Z. Chaudhari, Divya Teli, Pankti Balar, Lalitkumar Vora
Summary: Propolis is a chemically diverse substance produced by honeybees from plant resins, and has been used as a traditional remedy for various purposes. It has gained recognition in pharmaceutical and nutraceutical areas due to its diverse chemical composition and potential health benefits. Over 300 molecular structures have been discovered in propolis, and it has been found to have various pharmacological activities. Abundant research has been conducted to explore propolis as an alternative therapy for chronic diseases, and clinical trials have shown its potency in preventing and curing certain conditions.
Review
Chemistry, Multidisciplinary
Vivek P. Chavda, Anjali Pandya, Lalit Kumar, Nidhi Raval, Lalitkumar K. Vora, Sreeranjini Pulakkat, Vandana Patravale, Yanhong Duo, Ben Zhong Tang
Summary: This paragraph introduces the formation, structure, and function of exosomes, which play an important role in intercellular communication and are associated with health and disease. Recently, exosome-based nanotechnology has provided opportunities for the development of next-generation nanomedicines. This review summarizes the recent advances in exosome nanotechnology research, including classification, isolation and preparation, constitution, biological function, and nanobiomedical applications in disease treatment and diagnosis, and prospects for the future.
Review
Pharmacology & Pharmacy
Vivek P. Chavda, Kajal P. Baviskar, Dixa A. Vaghela, Shilpa S. Raut, Anjali P. Bedse
Summary: Clinical management of COVID-19 is challenging, and vaccines are considered the first line of defense. Studies on immune response focus on innate responses and cell-mediated systemic immunity. Due to difficulties with conventional routes, alternative prophylaxis and therapy routes are needed. Nasal vaccines are under development and can be self-administered for prevention and therapeutic purposes. Nasal drug delivery offers advantages such as needle-free administration and no refrigeration requirement. This article discusses various aspects of nasal sprays for eliminating COVID-19.
PHARMACOLOGICAL REPORTS
(2023)
Review
Immunology
Vivek P. Chavda, Nidhi Raval, Soham Sheta, Lalitkumar K. Vora, Fatma Elrashdy, Elrashdy M. Redwan, Vladimir N. Uversky, Yavuz Nuri Ertas
Summary: The newly emerged SARS-CoV-2 is highly infectious and rapidly mutating, causing severe effects on various body organs. Multiple approaches, including medications and supportive devices, have been successfully used for the intervention of COVID-19. Hemadsorption devices are discussed in this report as part of supportive treatment for the cytokine storm associated with COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Amol D. Gholap, Sadikali F. Sayyad, Navnath T. Hatvate, Vilas V. Dhumal, Sagar R. Pardeshi, Vivek P. Chavda, Lalitkumar K. Vora
Summary: Ongoing developments and research methods in drug technology and chemistry aim to enhance the effectiveness of drugs and protect their molecular integrity. Sunscreen application and UV filters are important for shielding against UV damage, however, avobenzone, a widely used UVA filter, is prone to photodegradation. Various strategies, such as encapsulation and antioxidants, have been explored to address this issue. This review aims to summarize recent literature on drug delivery strategies for the photostabilization of avobenzone, with the potential for industrial applications.
Editorial Material
Immunology
Vivek P. Chavda, Suneetha Vuppu, Toshika Mishra, Pankti Balar
Review
Immunology
Vivek P. Chavda, Disha D. Valu, Palak K. Parikh, Nikita Tiwari, Abu Sufiyan Chhipa, Somanshi Shukla, Snehal S. Patel, Pankti C. Balar, Ana Claudia Paiva-Santos, Vandana Patravale
Summary: Accurate identification at an early stage of infection is crucial for effective care, especially in the case of the COVID-19 pandemic caused by the SARS-CoV-2 virus. The primary diagnostic methods include RT-PCR molecular technique and immunodiagnostic procedures. However, due to the increasing demand for testing, inexperienced producers and laboratories have led to the potential for errors in test results. Point-of-care testing and smart diagnostic techniques based on AI-ML and nanotechnology are discussed as potential solutions for rapid and accurate detection of SARS-CoV-2.
Editorial Material
Infectious Diseases
Vivek P. Chavda, Vasso Apostolopoulos, Ranjit Sah
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Vivek P. Chavda, Vasso Apostolopoulos
Article
Medicine, General & Internal
Kashvi C. Shah, Nishi S. Patel, Paritosh Vasani, Avinash Khadela, Vivek P. Chavda, Lalitkumar Vora
Summary: A 53-year-old Asian patient developed involuntary muscle movements, impaired speech, and generalized tremors after taking phenytoin, which were successfully reversed with prompt identification and treatment. This case provides valuable reference for the diagnosis and treatment prognosis of phenytoin-induced dyskinesia.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Letter
Critical Care Medicine
Vivek P. Chavda, Kaushika Patel, Harsh Mod, Vasso Apostolopoulos
LANCET RESPIRATORY MEDICINE
(2023)
Review
Oncology
Avinash Khadela, Vivek P. P. Chavda, Shruti Soni, Kaivalya Megha, Aanshi J. J. Pandya, Lalitkumar Vora
Summary: This literature aims to explore the characteristics of anti-androgens against luminal androgen receptor-specific triple-negative breast cancer and provides a concise report on the clinical profile of anti-androgens. This review summarizes the types of triple-negative cancer cells, along with a brief discussion of the involvement of androgen receptors in the luminal type. The paper describes the evidence obtained from clinical trials and presents conclusions to assist clinicians in developing optimal strategies for mitigating LAR-TNBC and providing better patient care.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
